The Experimental Eczema of the Guinea-Pig Nipple*

Hypersensitivity in Mice

“…This view is supported by passive transfer of contact hypersensitivity to oxazolone by means of peri toneal exudate cells, as achieved recently by A siierso n and P ta k f 1 ]. The histogenesis of the sensitivity reaction displayed by the mouse ear is similar to that of contact dermatitis of the guinea pig [12,20,36], In both instances, qualitatively similar changes can occur in aller gic and toxic dermatitis, the extent of initial damage to the epi dermis being determined by the nature and the amount of migrating inflammatory colls. In the present case of contact sensitivity to oxazolonc an 'eczematoicl' reaction is produced with early and predom inant mononuclear cell infiltration, in contrast to the rather weak primary irritant effect of oxazolone in the non-sensitized animal.…”

Relationship Between Epithelial Cell Proliferation and Lymphoid Cell Infiltration in Contact Reactions in Guinea Pigs

“…The allergic skin responds to stimulation with the specific contact allergen with an increase in mitotic activity leading to acanthosis [18,22]. One way of explaining this phenomenon is to regard it as a secondary, non-specific reparative process.…”

The Mechanism of Contact Sensitisation

“…Although there is a superficial resemblance between the primary toxic effect of a large dose of PC and DNCB in a non-sensitised guinea-pig and the effect of a much smaller dose of the same compound in a sensitised guinea-pig the histological character of the lesion in the two instances is different (Jadassohn, Bujard and Brun, 1955 ;de Weck and Brun, 1956;Fisher and Cooke, 1958a). The primary toxic response is characterised by degeneration of epidermal cells with moderate leucocytosis, whilst the allergic response is characterised by a rapid massive extravasation of mononuclear cells migrating in trails directly into the 1 epidermis.…”