The experimental study of TNF-α &amp; CRP expression in the spinal tuberculosis after instrumentation

Risantoso, Tjuk; Hidayat, M. Taufik; Suyuti, Hidayat; Aulanni’am, Aulanni’am

doi:10.1016/j.amsu.2021.103048

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…IL-32 has been proven to be a pro-inflammatory cytokine that can induce other cytokines involved in inflammation ( 19 ). Some studies have demonstrated that CRP increased in tuberculosis patients, and these levels declined with the progress of treatment ( 20 , 21 ). Herein, IL-32 was found to be significantly correlated with clinical inflammation indicator CRP, further validating the pro-inflammatory effect of IL-32.…”

Section: Discussionmentioning

confidence: 99%

The regulation and potential role of interleukin-32 in tuberculous pleural effusion

Wang,

Yang,

Quan

et al. 2024

Front. Immunol.

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The possible protective effect of interleukin-32 (IL-32) in Mycobacterium tuberculosis (Mtb) infection has been indicated. However, few studies have been focused on IL-32 in tuberculosis patients. Additionally, the regulation of IL-32 production has rarely been reported. In the present study, the production, regulation, and role of IL-32 in tuberculous pleurisy (TBP) were investigated. We found that the content of IL-32 in tuberculous pleural effusion (TPE) was higher than the level in the malignant pleural effusion and transudative pleural effusion. The level of IL-32 mRNA in pleural fluid mononuclear cells (PFMCs) was higher than that in peripheral blood mononuclear cells (PBMCs) of patients with TBP, and this difference was mainly reflected in the splice variants of IL-32α, IL-32β, and IL-32γ. Compared with the PBMCs, PFMCs featured higher IL-32β/IL-32γ and IL-32α/IL-32γ ratios. In addition, lipopolysaccharide (LPS), Bacillus Calmette-Guérin (BCG), and H37Ra stimulation could induce IL-32 production in the PFMCs. IL-32 production was positively correlated with the TNF-α, IFN‐γ, and IL-1Ra levels in TPE, whereas IFN-γ, but not TNF-α or IL-1Ra, could induce the production of IL-32 in PFMCs. Furthermore, IL-32γ could induce the TNF-α production in PFMCs. Monocytes and macrophages were the main sources of IL-32 in PFMCs. Nevertheless, direct cell–cell contact between lymphocytes and monocytes/macrophages plays an important role in enhancing IL-32 production by monocyte/macrophage cells. Finally, compared with the non-tuberculous pleural effusion, the purified CD4+ and CD8+ T cells in TPE expressed higher levels of intracellular IL-32. Our results suggested that, as a potential biomarker, IL-32 may play an essential role in the protection against Mtb infection in patients with TBP. However, further studies need to be carried out to clarify the functions and mechanisms of the IFN-γ/IL-32/TNF-α axis in patients with TBP.

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Section: Discussionmentioning

confidence: 99%

The regulation and potential role of interleukin-32 in tuberculous pleural effusion

Wang,

Yang,

Quan

et al. 2024

Front. Immunol.

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“…25 Infective spondylitis can be monitored effectively with spinal CT and MRI, but there is still limited correlation between disease activity and epidural abscess/bone destruction; perioperative inflammatory index changes may be useful in determining the severity of the disease. 3,26 Postoperative failure may be increased by a high preoperative infection index in infectious spondylitis. According to most studies, preoperative ESR does not correlate significantly with prognosis due to the fact that in many cases, it is not consistent with clinical manifestations and is easily affected by a variety of disease states, while CRP is highly sensitive and specific.…”

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confidence: 99%

Comparative Study on the Efficacy of Two Perioperative Chemotherapy Regimens for Lumbar Brucellosis

Wang,

Deng,

Ding

et al. 2023

DDDT

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The clinical efficacy of perioperative chemotherapy regimen (rifampicin, doxycycline, levofloxacin, ceftriaxone) was evaluated for lumbar brucellosis spondylitis patients with neurological injury. Methods: In Beijing Ditan Hospital affiliated with Capital Medical University, 32 patients with lumbar brucellosis spondylitis underwent surgery and triple perioperative chemotherapy (rifampicin, doxycycline, levofloxacin) between 2011 and 2021 due to neurological injury, and 34 patients matched up with the triple group underwent rifampicin, doxycycline, levofloxacin, and ceftriaxone. Both groups were compared in terms of changes in inflammation index, low back/leg pain, lumbar function, neurological function, and adverse drug reactions. Results: There was no significant difference in erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), low back pain visual analogue scale (VAS), leg pain VAS, lumbar Oswestry disability index (ODI) and nerve function injury rate between the two groups before chemotherapy (P>0.05). The ESR, CRP at 1 week and 2 weeks after chemotherapy and 1 week, 2 weeks, 1 month postoperatively in the quadruple group were significantly lower than those in the triple group, which is the same to ESR 3 months postoperatively (P<0.05). The low back pain VAS, leg pain VAS and lumbar ODI in the quadruple group were significantly lower than those in the triple group at 1 month and 3 months postoperatively (P<0.05). The recovery rate of neurological function in the quadruple group was significantly higher than that in the triple group at 3 and 6 months postoperatively (P<0.05). Both groups did not experience significantly different perioperative and postoperative adverse reactions (P>0.05). Conclusion:For lumbar brucellosis spondylitis with neurological injury, quadruple perioperative chemotherapy of rifampicin, doxycycline, levofloxacin and ceftriaxone can significantly reduce perioperative inflammation, and improve low back/leg pain, as well as promoting neurological function recovery in the short term.

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Antimycobacterial compounds produced by forest fungi: An overview

Meskini,

Rami,

Ghosh

2025

Forest Fungi

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The experimental study of TNF-α & CRP expression in the spinal tuberculosis after instrumentation

Cited by 4 publications

References 18 publications

The regulation and potential role of interleukin-32 in tuberculous pleural effusion

The regulation and potential role of interleukin-32 in tuberculous pleural effusion

Comparative Study on the Efficacy of Two Perioperative Chemotherapy Regimens for Lumbar Brucellosis

Antimycobacterial compounds produced by forest fungi: An overview

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