The Explosion of Ethyl Azide<sup>1</sup>

Campbell, Hallock C.; Rice, O. K.

doi:10.1021/ja01309a019

Cited by 9 publications

(3 citation statements)

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“…The required azide for the transformation was ethyl azide ( 2 ), a highly energetic, volatile, and generally dangerous compound. This compound has been reported to explode at room temperature, emphasizing the associated hazards …”

Section: Case Study 1: Elimination/substitution Of Highly Hazardous M...mentioning

confidence: 99%

Process Safety in the Pharmaceutical Industry: A Selection of Illustrative Case Studies

et al. 2020

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Awareness of best safety practices in the industrial sector will allow students in chemistry and chemical engineering programs to apply these approaches to their own safety assessments. Process safety is a critical function within the pharmaceutical industry to ensure safety when performing reactions. An introduction to process safety and a series of case studies illustrating how safety is routinely considered within the pharmaceutical industry is presented. The concepts presented herein are applicable to multiple industries, academic research, and chemical reactions conducted on all scales. The case studies include examples where a synthesis was redesigned to afford a triazole intermediate without forming potentially explosive byproducts, an exothermic reaction was controlled by understanding the heat output with time and developing a portion-wise addition procedure, and a reaction that displayed extremely fast gas evolution was managed by using an alternative solvent and controlling the rate of reagent addition.

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Section: Case Study 1: Elimination/substitution Of Highly Hazardous M...mentioning

confidence: 99%

Process Safety in the Pharmaceutical Industry: A Selection of Illustrative Case Studies

et al. 2020

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show abstract

“…What the methods should be is an important part of the problem (see comments on pages 36,37 and 76 of reference [1]). …”

Section: First Appraisal Of Methods For Estimating Self-reaction Hazardsmentioning

confidence: 99%

“…B-54b but with the constant 2.7 replaced by 2.85' . The analysis of Rice et al (see [35], also [36,37] The recent mathematical investigation of Gray and Sherrington (see [38] p. 448, fig. 2,3) determines directly the conditions for an inflection point in the 9,t curve.…”

Section: B-54bmentioning

confidence: 99%