The expression and function of miR-622 in a variety of tumors

Lü, Juan; Xie, Zhongyang; Xiao, Zhaoying; Zhu, Danhua

doi:10.1016/j.biopha.2021.112544

Cited by 10 publications

(6 citation statements)

References 59 publications

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“…5) remains underexplored. For miR-622, the literature also reports that this retro-miR can act as both a tumor suppressor and an onco-miR in several cancers, such as breast cancer, glioma, colorectal cancer, hepatocellular carcinoma (HCC), lung cancer, gastric cancer (GC), melanoma, ovarian carcinoma, prostate cancer, and pancreatic cancer [40], which is in agreement with our results (Fig. 5).…”

Section: Discussionsupporting

confidence: 93%

Retro-miRs: Novel and functional miRNAs originating from mRNA retrotransposition

Mercuri

Conceicao

Guardia

et al. 2023

Preprint

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Background. Reverse-transcribed gene copies (retrocopies) have emerged as major sources of evolutionary novelty. MicroRNAs (miRNAs) are small and highly conserved RNA molecules that serve as key post-transcriptional regulators of gene expression. The origin and subsequent evolution of miRNAs have been addressed but not fully elucidated. Results.In this study, we performed a comprehensive investigation of miRNA origination through retroduplicated mRNA sequences (retro-miRs). We identified 17 retro-miRs that emerged from the mRNA retrocopies. Four of these retro-miRs had de novo origins within retrocopied sequences, while 13 retro-miRNAs were located within exon regions and duplicated along with their host mRNAs. We found that retro-miRs were primate-specific, including five retro-miRs conserved among all primates and two human-specific retro-miRs. All retro-miRs were expressed, with predicted and experimentally validated target genes except miR-10527. Notably, the target genes of retro-miRs are involved in key biological processes such as metabolic processes, cell signaling, and regulation of neurotransmitters in the central nervous system. Additionally, we found that these retro-miRs play a potential oncogenic role in cancer by targeting key cancer genes and are overexpressed in several cancer types, including liver hepatocellular carcinoma and stomach adenocarcinoma. Conclusions. Our findings demonstrated that mRNA retrotransposition is a key mechanism for the generation of novel miRNAs (retro-miRs) in primates. These retro-miRs are expressed, conserved, have target genes with important cellular functions, and play important roles in cancer.

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Section: Discussionsupporting

confidence: 93%

Retro-miRs: Novel and functional miRNAs originating from mRNA retrotransposition

Mercuri

Conceicao

Guardia

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…5) remains underexplored. For miR-622, the literature also reports that this retro-miR can act as both a tumor suppressor and an onco-miR in several cancers, such as breast cancer, glioma, colorectal cancer, hepatocellular carcinoma (HCC), lung cancer, gastric cancer (GC), melanoma, ovarian carcinoma, prostate cancer, and pancreatic cancer [43], which is in agreement with our results (Fig. 5).…”

Section: Discussionsupporting

confidence: 93%

Retro-miRs: novel and functional miRNAs originating from mRNA retrotransposition

Mercuri,

Conceição,

Guardia

et al. 2023

Mobile DNA

View full text Add to dashboard Cite

Background Reverse-transcribed gene copies (retrocopies) have emerged as major sources of evolutionary novelty. MicroRNAs (miRNAs) are small and highly conserved RNA molecules that serve as key post-transcriptional regulators of gene expression. The origin and subsequent evolution of miRNAs have been addressed but not fully elucidated. Results In this study, we performed a comprehensive investigation of miRNA origination through retroduplicated mRNA sequences (retro-miRs). We identified 17 retro-miRs that emerged from the mRNA retrocopies. Four of these retro-miRs had de novo origins within retrocopied sequences, while 13 retro-miRNAs were located within exon regions and duplicated along with their host mRNAs. We found that retro-miRs were primate-specific, including five retro-miRs conserved among all primates and two human-specific retro-miRs. All retro-miRs were expressed, with predicted and experimentally validated target genes except miR-10527. Notably, the target genes of retro-miRs are involved in key biological processes such as metabolic processes, cell signaling, and regulation of neurotransmitters in the central nervous system. Additionally, we found that these retro-miRs play a potential oncogenic role in cancer by targeting key cancer genes and are overexpressed in several cancer types, including liver hepatocellular carcinoma and stomach adenocarcinoma. Conclusions Our findings demonstrated that mRNA retrotransposition is a key mechanism for the generation of novel miRNAs (retro-miRs) in primates. These retro-miRs are expressed, conserved, have target genes with important cellular functions, and play important roles in cancer.

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“…However, the importance of this retro-miR in other tumors (Figure 5) remains underexplored. For miR-622, the literature also reports that this retro-miR can act as both a tumor suppressor or an onco-miR in several cancers, such as breast cancer, glioma, CRC, hepatocellular carcinoma (HCC), lung cancer, gastric cancer (GC), melanoma, ovarian carcinoma, prostatic cancer, and pancreatic cancer [40], in agreement with our expression results (Figure 5). Like the other two retro-miRs, the literature reports that miR-492 acts as both a tumor suppressor and an oncogene.…”

Section: Discussionsupporting

confidence: 92%

Retro-miRs: Novel and functional miRNAs originated from mRNA retrotransposition

Mercuri

Conceicao

Guardia

et al. 2023

Preprint

View full text Add to dashboard Cite

Reverse transcribed gene copies, or retrocopies, have emerged as a major source of evolutionary novelties. MicroRNAs (miRNAs) are small, highly conserved RNAs molecules among species that serve as key post-transcriptional regulators of gene expression. The birth and subsequent evolution of miRNAs have been addressed, but not fully. In this study, we carried out a comprehensive investigation of miRNAs origination through retroduplicated mRNA sequences (retrocopies). We identified 17 retroduplicated miRNAs (retro-miRs) that emerged from mRNAs retrocopies. Four of these retro-miRs had de novo origination within retrocopied sequences, while 13 retro-miRNAs were located within exon regions and were duplicated along with their host mRNAs. We found that retro-miRs are primates specific, including 5 retro-miRs conserved among all primates and two human-specific retro-miRs. All of the retro-miRs were expressed and had predicted and experimentally validated target genes, with the exception of miR-10527. Notably, the target genes of retro-miRs are involved in key biological processes, such as metabolic processes, cell signaling and regulation of neurotransmitters in the central nervous system. Additionally, we found that these retro-miRs have a potential oncogenic role in cancer, targeting key cancer genes and being overexpressed in several cancer types, including Liver Hepatocellular Carcinoma and Stomach Adenocarcinoma. Our findings demonstrate that mRNAs retrotransposition is a key mechanism for the generation of novel miRNAs (retro-miRs) in primates. These retro-miRs are expressed, conserved, have target genes with important cellular functions, and play roles in cancer.

show abstract

The expression and function of miR-622 in a variety of tumors

Cited by 10 publications

References 59 publications

Retro-miRs: Novel and functional miRNAs originating from mRNA retrotransposition

Retro-miRs: Novel and functional miRNAs originating from mRNA retrotransposition

Retro-miRs: novel and functional miRNAs originating from mRNA retrotransposition

Retro-miRs: Novel and functional miRNAs originated from mRNA retrotransposition

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