The Expression and Role of microRNA-133a in Plasma of Patients with Kawasaki Disease

Luo, Yeping; Yu, Meng; Li, Pengzhu; Huang, Lihua; Wu, Ji-Ping; Kong, Min; Liu, Ying; Wu, Zhixiang; Kang, Zhijuan; Lee, Yi; Yang, Zhangping

doi:10.1080/08820139.2021.1877302

Cited by 6 publications

(8 citation statements)

References 42 publications

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“…Subsequently, 22 articles were excluded after full text screening. Finally, 12 articles containing 18 studies were eligible for inclusion in this systematic review and meta-analysis (12,(19)(20)(21)(22)(23)(27)(28)(29)(30)(31)(32). The flow diagram of the selection process of this meta-analysis is presented in…”

Section: Resultsmentioning

confidence: 99%

“…A previous study indicated that ncRNAs play key roles in regulating gene expression in cardiovascular phylogeny, physiology and disease physiology ( 10 ). Several studies have demonstrated that ncRNAs have the potential to be biomarkers for risk stratification, diagnosis and prognosis of cardiovascular diseases ( 11 , 12 ). A previous study found that miRNAs are readily detectable in the plasma and protected from RNase degradation by sequestration, suggesting that miRNAs are suitable as ideal biomarkers ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

“…A previous systematic review/meta-analysis found that the neutrophil-to-lymphocyte ratio could be used as a biomarker in IVIG-resistant KD ( 17 ), and another meta-analysis studied the diagnostic significance of miRNAs in KD ( 18 ). Several recent studies have focused on the diagnostic accuracy of ncRNAs for KD-CAL and their value in differentiating the acute phase of KD and convalescent KD ( 12 , 19 – 23 ). However, none of the systematic reviews/meta-analysis studied the diagnostic accuracy of ncRNAs in KD-CAL or the accuracy in differentiating the acute phase of KD and convalescent KD patients.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic significance of noncoding RNAs in kawasaki disease: A systematic review and meta-analysis

et al. 2023

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ObjectiveKawasaki disease (KD) is a systemic vasculitis disease, and early effective intervention would reduce the occurrence of coronary artery lesions (CALs). Recently, many scholars have been committed to studying the relationship between noncoding RNAs and KD. This systematic review aimed to analyze the diagnostic value of noncoding RNAs(ncRNAs) in distinguishing different KD status.MethodsWe searched for the literature about diagnostic values of ncRNAs in KD in CNKI, VIP, Wanfang, China Biomedical Literature Database as well as PubMed, Web of Science, Embase, and Cochrane Library up to April 15, 2022. All included studies were further analyzed using STATA 12.0, Meta-disc 1.4 and RevMan 5.4 software.ResultsA total of six studies investigating the diagnostic performance of ncRNAs in differentiating KD-CAL (n = 101) from KD-NCAL patients (n = 123) were included in this this meta-analysis. The calculated area under the curve(AUC) was 0.83 (0.80–0.86). Four studies on the diagnostic performance of ncRNAs in differentiating acute KD patients (n = 139) from convalescent KD patients (n = 109) were included. The calculated AUC was 0.87 (0.84–0.90). Four studies focused on the diagnostic performance of ncRNAs combined with other laboratory indexes in KD by assessing 137 KD patients and 152 febrile controls. The calculated AUC was 0.90 (0.87–0.92). Four studies assessed the diagnostic performance of ncRNAs in differentiating intravenous immunoglobulin (IVIG)-resistant KD patients from IVIG-responsive KD patients. The calculated AUC was 0.9135 ± 0.0307. These results indicated that ncRNAs have a good diagnostic efficacy in KD.ConclusionsThis meta-analysis showed that ncRNAs have potential as a biomarker for distinguishing different KD status. However, since limited studies were included in this meta-analysis, larger and well-designed diagnostic studies should be conducted to validate these results.Systematic Review RegistrationINPLASY.COM, identifier: doi: 10.37766/inplasy2022.10.0035.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic significance of noncoding RNAs in kawasaki disease: A systematic review and meta-analysis

et al. 2023

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“…[32] Stata 12.0 software (version 12, College Station, TX), Meta-Disc 1.4 and Review Manager Version 5.4 (Cochrane, Oxford, UK) were used to perform this meta-analysis. Chu MP 2015 [33] 0.693 0.886 0.760 35 15 44 Chu MP 2015 [33] 0.862 0.846 0.854 43 7 42 Chu MP 2015 [33] 0.800 0.911 0.853 40 10 46 Chu MP 2015 [33] 0.770 0.841 0.747 38 12 42 Guan YQ 2020 [34] 0.929 0.429 0.732 26 2 12 Hu QQ 2020 [35] 0.567 0.900 0.726 17 13 27 Wang LN 2019 [36] 0.970 0.910 0.960 10 0 7 Sheng W 2016 [37] 0.644 0.900 0.773 29 16 27 Sheng W 2016 [37] 0.664 0.867 0.816 29 16 26 Chen RY 2020 [38] 0.767 1.000 0.920 23 7 30 Chen RY 2020 [38] 0.766 0.952 0.833 23 7 19 Jia L 2016 [39] 0.846 0.714 0.736 28 5 11 Sun J 2015 [40] 1.000 1.000 1.000 26 0 22 Jing F 2022 [41] 0.769 0.834 0.811 10 3 24 Jone PN 2020 [42] 0.876 0.580 0.769 74 10 17 Jone PN 2020 [42] 0.801 0.807 0.804 21 5 23 Jone PN 2020 [42] 0.816 0.618 0.717 47 11 18 Wang B 2019 [43] 0.949 0.798 0.940 15 1 13 Luo Y 2022 [44] 0.967 0.800 0.930 29 1 48 LV HF 2020 [45] 0.847 0.787 0.886 127 23 118 Ning Q 2020 [46] 0.818 0.857 0.890 27 8 24 Rong X 2016 [47] 0.733 0.889 0.858 33 12 27 Rong X 2016 [47] 0.733 0.733 0.761 33 12 22 Weng KP 2021 [48] 0.831 0.842 0.834 60 12 32 Weng KP 2021 [48] 0.563 0.818 0.729 41 31 27 Wu J 2019 [49] 0.723 0.589 0.624 40 16 33 Wu J 2019 [49] 0.822 0.600 0.747 37 8 27 Yan J 2019 [50] 0.867 0.735 0.754 29 4 11 Zhang R 2020 [51] 0.830 0.890 0.921 83 17 89 Zhang W 2017 [52] 0.600 0.800 0.790 61 41 64 Zhang W 2017 [52] 0.667 0.866 0.890 68 34 69 Zhou Q 2021 [53] 0.550 0.725 0.633 22 18 29 Zhou Q 2021 [53] 0.700 0.825 0.743 28 12 33 Wang Z 2019 …”

Section: Discussionmentioning

confidence: 99%

Association of noncoding RNAs with Kawasaki disease: A meta-analysis based on the current evidences

Zhong,

Wang,

Jia

et al. 2023

Medicine

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Background: In recent years, many studies have focused on the relationship between noncoding RNAs (ncRNAs) and Kawasaki disease (KD). Studies have indicated that ncRNAs are associated with the occurrence and development of KD. Thus, we performed a systematic review and meta-analysis to investigate the diagnostic value of ncRNAs in KD patients. Methods: We searched the PubMed, Web of Science, Embase and Cochrane Library, China National Knowledge Infrastructure, VIP, China Biology Medicine disc databases, and Wanfang databases until August 25, 2023 and screened all eligible studies focusing on the diagnostic performance of ncRNAs in KD patients. Results: In total, 535 articles were found, and 28 articles were included in this systematic review and meta-analysis. The calculated area under the curve value was 0.880 (95% confidence intervals, 0.840–0.900). The pooled sensitivity, specificity, positive likelihood ratio and negative likelihood ratio were 0.790, 0.830, 4.610, and 0.260, respectively. The pooled diagnostic odds ratio was 17.890 (95% confidence intervals, 13.110–24.420), indicating a relatively good diagnostic performance of the ncRNAs for detecting KD. In addition, the diagnostic value of micro RNAs in KD was better than that of long noncoding RNAs and circular noncoding RNAs. A subgroup analysis by specimen indicated a better diagnostic value of ncRNAs in plasma and platelet than serum. The diagnostic accuracy of ncRNAs was better in febrile controls than in healthy control groups, indicating a relatively good accuracy in distinguishing KD patients from febrile diseases. Conclusions: This systematic review and meta-analysis demonstrated that ncRNAs could be used as novel biomarkers for detecting KD. More studies should be conducted in the future to verify the diagnostic values of ncRNAs in KD.

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“…Luo et al. proclaimed that overexpressed miR-133a in KD patients inhibited the expression of PPP2CA, a catalytic submit of PP2A, thus leading to the cleave of VE-cadherin and vascular dysfunction ( 84 ). Endothelial-mesenchymal transition (EndoMT) takes a leading position in coronary arterial wall destruction.…”

Section: The Inherent Mechanism Of Mirnas In Kawasaki Diseasementioning

confidence: 99%

MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring

Xiong

Zhang

et al. 2022

Front. Immunol.

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Kawasaki disease (KD) is an acute autoimmune vascular disease featured with a long stage of febrile. It predominantly afflicts children under 5 years old and causes an increased risk of cardiovascular combinations. The onset and progression of KD are impacted by many aspects, including genetic susceptibility, infection, and immunity. In recent years, many studies revealed that miRNAs, a novel class of small non-coding RNAs, may play an indispensable role in the development of KD via differential expression and participation in the central pathogenesis of KD comprise of the modulation of immunity, inflammatory response and vascular dysregulation. Although specific diagnose criteria remains unclear up to date, accumulating clinical evidence indicated that miRNAs, as small molecules, could serve as potential diagnostic biomarkers and exhibit extraordinary specificity and sensitivity. Besides, miRNAs have gained attention in affecting therapies for Kawasaki disease and providing new insights into personalized treatment. Through consanguineous coordination with classical therapies, miRNAs could overcome the inevitable drug-resistance and poor prognosis problem in a novel point of view. In this review, we systematically reviewed the existing literature and summarized those findings to analyze the latest mechanism to explore the role of miRNAs in the treatment of KD from basic and clinical aspects retrospectively. Our discussion helps to better understand the pathogenesis of KD and may offer profound inspiration on KD diagnosis, treatment, and prognosis.

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The Expression and Role of microRNA-133a in Plasma of Patients with Kawasaki Disease

Cited by 6 publications

References 42 publications

Diagnostic significance of noncoding RNAs in kawasaki disease: A systematic review and meta-analysis

Diagnostic significance of noncoding RNAs in kawasaki disease: A systematic review and meta-analysis

Association of noncoding RNAs with Kawasaki disease: A meta-analysis based on the current evidences

MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring

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