The Expression of Hemagglutinin by a Recombinant Newcastle Disease Virus Causes Structural Changes and Alters Innate Immune Sensing

Ingrao, F; Duchatel, Victoria; Rodil, Isabel Fernandez; Steensels, Mieke; Verleysen, Eveline; Mast, Jan; Lambrecht, Bénédicte

doi:10.3390/vaccines9070758

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…Although NDV-vectored vaccines are promising, interference from MDA is a major concern related to their clinical application [ 74 ]. Using the common strategy of vaccine generation, foreign antigens are incorporated into the envelope of virus particles [ 79 ]. Therefore, antibodies against NDV as well as foreign antigens can impact vectored vaccines.…”

Section: Commercial Nd Vaccinesmentioning

confidence: 99%

Current situation and future direction of Newcastle disease vaccines

Deng

et al. 2022

Vet Res

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Newcastle disease (ND) is one of the most economically devastating infectious diseases affecting the poultry industry. Virulent Newcastle disease virus (NDV) can cause high mortality and severe tissue lesions in the respiratory, gastrointestinal, neurological, reproductive and immune systems of poultry. Tremendous progress has been made in preventing morbidity and mortality caused by ND based on strict biosecurity and wide vaccine application. In recent decades, the continual evolution of NDV has resulted in a total of twenty genotypes, and genetic variation may be associated with disease outbreaks in vaccinated chickens. In some countries, the administration of genotype-matched novel vaccines in poultry successfully suppresses the circulation of virulent NDV strains in the field. However, virulent NDV is still endemic in many regions of the world, especially in low- and middle-income countries, impacting the livelihood of millions of people dependent on poultry for food. In ND-endemic countries, although vaccination is implemented for disease control, the lack of genotype-matched vaccines that can reduce virus infection and transmission as well as the inadequate administration of vaccines in the field undermines the effectiveness of vaccination. Dissection of the profiles of existing ND vaccines is fundamental for establishing proper vaccination regimes and developing next-generation vaccines. Therefore, in this article, we provide a broad review of commercial and experimental ND vaccines and promising new platforms for the development of next-generation vaccines.

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Section: Commercial Nd Vaccinesmentioning

confidence: 99%