The expression of human leukocyte antigens class I and II in women with endometriosis or adenomyosis

Baka, Stavroula; Frangou-Plemenou, Matrona; Panagiotopoulou, Ekaterina; Makrakis, Evangelos; Kaltsakas, Georgios; Hassiakos, D.; Kondi-Pafiti, A

doi:10.3109/09513590.2010.495429

Cited by 15 publications

(17 citation statements)

References 33 publications

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“…102 This uterine microenvironment is likely to significantly impact functionally relevant uNK cells in women with endometriosis. 71,105 Given that functioning uNK cells are vital for successful implantation and placentation, this change in activity may be key to endometriosis-associated infertility. However, resistance of eutopic endometrial cells to NK cell lysis may be an important factor as HLA class I expression is significantly higher in women with endometriosis compared to normal control subjects.…”

Section: Uterine Nk Cells Endometriosis and Infertilitymentioning

confidence: 99%

“…However, resistance of eutopic endometrial cells to NK cell lysis may be an important factor as HLA class I expression is significantly higher in women with endometriosis compared to normal control subjects. 71,105 Given that functioning uNK cells are vital for successful implantation and placentation, this change in activity may be key to endometriosis-associated infertility. With such a clear role in successful fertility, it is surprising that so few studies have explored how uNK cells might explain the aetiology of endometriosis.…”

Section: Uterine Nk Cells Endometriosis and Infertilitymentioning

confidence: 99%

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Natural Killer Cells: Key Players in Endometriosis

Thiruchelvam

Wingfield

O’Farrelly

2015

American J Rep Immunol

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Endometriosis affects more than 10% of women, causing significant pain and morbidity. It is also a significant cause of infertility. The aetiology of the disease remains an enigma, and the mechanisms responsible for the associated infertility are unclear. A role for immune cells in endometriosis has been postulated, with attention directed towards natural killer (NK) cells and macrophages. NK cells kill tumours and infected cells but also have roles in tissue remodelling in several organs including the uterus and are key to successful pregnancy. Here, we explore evidence (from peer-reviewed published articles) of phenotypic and functional abnormalities in NK cell subpopulations of women with endometriosis. It is clear that peripheral blood NK cells and peritoneal NK cells have reduced cytotoxic function in women with endometriosis. Uterine NK cells have a vital role in infertility, but very little research has been carried out in this area. We propose that abnormal u NK cell activity may contribute to the pathogenesis of endometriosis and its associated infertility and that future research should focus on this complex area.

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Section: Uterine Nk Cells Endometriosis and Infertilitymentioning

confidence: 99%

Section: Uterine Nk Cells Endometriosis and Infertilitymentioning

confidence: 99%

Natural Killer Cells: Key Players in Endometriosis

Thiruchelvam

Wingfield

O’Farrelly

2015

American J Rep Immunol

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“…The MHC, also known as Human Leukocyte Antigens (HLA), are cell surface proteins that mediate interactions between immune responsive cells. Aberrant expression of both Class I and II MHC antigens in endometriotic lesions inhibits the cytotoxic activity of NK cells [143,144]. Some studies have suggested that the class I antigens HLA-B*07 and B*46 are associated with the development of endometriosis, whereas HLA-B*48 may offer a protective effect [145,146].…”

Section: Introductionmentioning

confidence: 99%

Molecular aspects of development and regulation of endometriosis

Aznaurova

Жуматаев

Roberts

et al. 2014

Reprod Biol Endocrinol

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Endometriosis is a common and painful condition affecting women of reproductive age. While the underlying pathophysiology is still largely unknown, much advancement has been made in understanding the progression of the disease. In recent years, a great deal of research has focused on non-invasive diagnostic tools, such as biomarkers, as well as identification of potential therapeutic targets. In this article, we will review the etiology and cellular mechanisms associated with endometriosis as well as the current diagnostic tools and therapies. We will then discuss the more recent genomic and proteomic studies and how these data may guide development of novel diagnostics and therapeutics. The current diagnostic tools are invasive and current therapies primarily treat the symptoms of endometriosis. Optimally, the advancement of “-omic” data will facilitate the development of non-invasive diagnostic biomarkers as well as therapeutics that target the pathophysiology of the disease and halt, or even reverse, progression. However, the amount of data generated by these types of studies is vast and bioinformatics analysis, such as we present here, will be critical to identification of appropriate targets for further study.

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“…The MHC, also known as Human Leukocyte Antigens (HLA), are cell-surface proteins that mediate interactions between immune responsive cells. Aberrant expression of both Class I and II MHC antigens in endometriotic lesions inhibits the cytotoxic activity of natural killer cells (NK) (73,74). Some studies have suggested that the class I antigens HLA-B*07 and B*46 are associated with the development of endometriosis, whereas HLA-B*48 may offer a protective effect (75,76).…”

Section: Cellular Mechanismsmentioning

confidence: 99%

Endometriosis diagnosis and medical treatment: Present and future

Núñez-Troconis

2021

Gaceta Médica De Caracas

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The objective was to review the different diagnostic methods and medical treatments for endometriosis. It was reviewed the Latin-American and international bibliography using the Pub-Med, Google Scholar, Springer, the Cochrane Library, Embase, Scielo, Imbiomed-L, Redalyc, and Latindex websites. The searches included the keywords: endometriosis, endometriotic, endometrial and ectopic endometrium, angiogenesis, angiogenesis and endometriosis, endometriosis, and medical treatment, endometriosis, and new treatment.

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The expression of human leukocyte antigens class I and II in women with endometriosis or adenomyosis

Abstract: Women with endometriosis had a significantly higher expression of HLA molecules whereas in adenomyosis there was a tendency of lower expression of these molecules. This could explain the suppression of cellular immunity in the peritoneal cavity.

Cited by 15 publications

References 33 publications

Natural Killer Cells: Key Players in Endometriosis

Natural Killer Cells: Key Players in Endometriosis

Molecular aspects of development and regulation of endometriosis

Endometriosis diagnosis and medical treatment: Present and future

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