The Expression of Myoglobin and ROR2 Protein in Dupuytren's Disease

Whole genome and global expression profiling of Dupuytren's disease: systematic review of current findings and future perspectives

“…Eight global messenger RNA expression microarray studies5–12 and one microRNA profiling13 study were identified (see supplementary table S1, available online only). Four sets of microarray data on DD were identified at both the National Center for Biotechnology Information gene expression omnibus (GEO) and the European Bioinformatics Institute array express record ID for GEO: GSE4457, GSE2688, GSE21221 and GSE31356.…”

“…MicroRNA are post-transcriptional regulators that negatively regulate their mRNA targets 17. Mosakhani et al 13 compared the microRNA profiles in their study with the mRNA expression profiles in the study by Forsman et al ,5 and showed concurrence on the downregulation of microRNA and upregulation of their target mRNA. The genes highlighted by Mosakhani et al 13 include: ADAM12, collagen, type V, alpha 2 (COL5A2), transforming growth factor β (TGFB)1, v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB), POSTN, TNC, wingless-type MMTV integration site family, member (WNT)5A and Zic family member 1 (ZIC1) (table 1).…”

Unique microRNA profile in Dupuytren's contracture supports deregulation of β-catenin pathway

“…7 Several studies have investigated the molecular pathogenesis of Dupuytren's contracture. These include gene-expression profiling, 5,[8][9][10][11][12] cytogenetic profiling, [13][14][15][16] and proteomic profiling. 17 These studies have identified genes that may potentially be involved in its pathogenesis.…”

Genome-Wide High-Resolution Screening in Dupuytren's Disease Reveals Common Regions of DNA Copy Number Alterations

“…Gene DYDC1 resides within the CNV found on 10q22.3, a region previously linked to myodegenerative disorders. 35 In the microarray study by Forsman et al, 36 muscle-related genes were the largest category with the greatest differential, usually reduced, expression in patients with DD. 36 The copy number gain at 16p12.1 includes the gene USP31.…”

“…35 In the microarray study by Forsman et al, 36 muscle-related genes were the largest category with the greatest differential, usually reduced, expression in patients with DD. 36 The copy number gain at 16p12.1 includes the gene USP31. Gene USP31 interacts with p65/RelA, a subunit of nuclear factor kappa beta (NF-␤), and it appears to have a role in the regulation of NF-␤ activation by members of the tumor necrosis factor receptor superfamily.…”