The Extent of Subclinical Atherosclerosis Is Partially Predicted by the Inflammatory Load: A Prospective Study over 5 Years in Patients with Rheumatoid Arthritis and Matched Controls

Södergren, Anna; Karp, Kjell; Bengtsson, Christine; Möller, Bozena; Rantapää-Dahlqvist, Solbritt; Wållberg‐Jonsson, Solveig

doi:10.3899/jrheum.140694

Cited by 23 publications

(31 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In RA, inflammation and atherosclerosis are closely linked. Inflammation mediates its effects on atherosclerosis both through modulation of traditional risk factors and through direct affecting the vessel wall and contributing to plaque formation [39,40]. This systemic inflammation may result in impaired insulin sensitivity and subsequently enhance the impact of MetS.…”

Section: Inflammatory Markersmentioning

confidence: 99%

Cardiac Impairment in Rheumatoid Arthritis and Influence of Anti-TNFα Treatment

Lazúrová

Tomáš

2016

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

There is evidence that rheumatoid arthritis (RA) is associated with higher overall and cardiovascular (CV) morbidity and mortality as compared with general population. Increased prevalence of traditional risk factors and chronic inflammation, that has been recognized as independent CV risk factor, may play an important role in atherosclerosis and subsequently ischemic heart disease development. However, myocardial dysfunction as a result of chronic inflammation and secondarily myocardial fibrosis markedly participates on heart failure development. Proinflammatory cytokines, such as C-reactive protein, tumor necrosis factor alpha (TNFα), interleukins 1 and 6, that are markedly increased in RA, play a role in the acceleration of atherosclerosis as well as myocardial fibrosis development. Several studies documented that increased CV risk was associated with seropositivity, disease activity score, citrullination, and duration of RA. Early detection of heart dysfunction is based on echocardiographic detection of diastolic dysfunction resulting from myocardial inflammation and fibrosis. Some studies showed also higher prevalence of left ventricular systolic dysfunction and increased prevalence of cardiac arrhythmias as compared to non-RA population. There are still controversies on the impact of NT-proBNP in predicting cardiac impairment in RA patients. Some authors consider it to be a sensitive noninvasive predictor of subclinical CV disease in these patients and also a predictor of all-cause mortality independently on traditional CV risk factors. However, the correlation with parameters of cardiac function was confirmed only in a few studies. The impact of biological treatment on progression of atherosclerosis and heart failure is still controversial and seems to be not harmful in young patients with normal left ventricular function. The effect of biologics, especially anti-TNFα drugs, is probably related to the cardiac function before treatment. Larger prospective clinical, echocardiographic, and magnetic resonance studies are needed.

show abstract

Section: Inflammatory Markersmentioning

confidence: 99%

Cardiac Impairment in Rheumatoid Arthritis and Influence of Anti-TNFα Treatment

Lazúrová

Tomáš

2016

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

show abstract

“…This is well represented by coronary heart disease and atherosclerosis in which the genetic predisposition is largely based on IL6 receptor polymorphisms [136,137] and severity correlates with the extent and duration of chronic inflammation [138]. In general terms, we continue to affirm that the predisposition to complex diseases such as those based on autoimmunity and chronic inflammation is secondary to the coexistence of a permissive genetic background and specific environmental factors and MZ twins are excellent intuitive models to estimate these factors.…”

Section: Discussionmentioning

confidence: 97%

Lessons learned from twins in autoimmune and chronic inflammatory diseases

Generali

Ceribelli

Stazi

et al. 2017

Journal of Autoimmunity

View full text Add to dashboard Cite

“…Blood samples were obtained within a structured program on patients with early RA for prospective analysis of development of co-morbidity using the nationwide Swedish Rheumatoid Arthritis Registry [18–20]. In short, all eligible patients with newly diagnosed RA (ACR criteria) [21] are continuously enrolled into the register.…”

Section: Methodsmentioning

confidence: 99%

“…In short, all eligible patients with newly diagnosed RA (ACR criteria) [21] are continuously enrolled into the register. Between the years 2000 and 2004 all newly diagnosed patients with RA under the age of 60 years were included into a study on the progression of atherosclerosis [18–20]. Of these patients, 68 were followed up after five years, and data in the present study are from that follow up [20].…”

Section: Methodsmentioning

confidence: 99%

“…Between the years 2000 and 2004 all newly diagnosed patients with RA under the age of 60 years were included into a study on the progression of atherosclerosis [18–20]. Of these patients, 68 were followed up after five years, and data in the present study are from that follow up [20]. Forty three age- and sex matched controls were also included.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

High Concentrations of Angiopoietin-Like Protein 4 Detected in Serum from Patients with Rheumatoid Arthritis Can Be Explained by Non-Specific Antibody Reactivity

et al. 2017

Self Cite

View full text Add to dashboard Cite

Angiopoietin-like protein 4 (ANGPTL4) is suggested to be a master regulator of plasma triglyceride metabolism. Our aim was to study whether the previously reported high levels of ANGPTL4 detected in serum from patients with rheumatoid arthritis (RA) by ELISA was due to any specific molecular form of this protein (oligomers, monomers or fragments). ANGPTL4 levels were first determined in serum from 68 RA patients and 43 age and sex matched control subjects and the mean values differed by a factor of 5.0. Then, ANGPTL4 was analyzed after size exclusion chromatography (SEC) of serum samples. With serum from one of the RA patients with high levels of ANGPTL4, the dominant reactivity was found in fractions corresponding to high-molecular weight proteins. In addition, a minor peak of reactivity eluting late from the column was found both in the patient and in controls. By the use of HeteroBlock®, and by careful selection of antibodies, we documented non-specific reactions for ANGPTL4 in 39% of samples from the RA patients, most likely due to cross-reactivity of the antibodies with rheumatoid factor (RF). The corresponding figure for control subjects was 6.3%. After corrections for non-specific reactions, the mean level of ANGPTL4 in serum from RA patients was still significantly higher than in control individuals (mean levels were 101±62 and 67±39 ng/ml respectively, P = 0.02). We re-analyzed samples from our previously published studies on ANGPL4 levels in patients on hemodialysis and patients with diabetes type 2. These samples did not show false positive reactions. The levels of ANGPTL4 were comparable to those detected previously.

show abstract

The Extent of Subclinical Atherosclerosis Is Partially Predicted by the Inflammatory Load: A Prospective Study over 5 Years in Patients with Rheumatoid Arthritis and Matched Controls

Cited by 23 publications

References 39 publications

Cardiac Impairment in Rheumatoid Arthritis and Influence of Anti-TNFα Treatment

Cardiac Impairment in Rheumatoid Arthritis and Influence of Anti-TNFα Treatment

Lessons learned from twins in autoimmune and chronic inflammatory diseases

High Concentrations of Angiopoietin-Like Protein 4 Detected in Serum from Patients with Rheumatoid Arthritis Can Be Explained by Non-Specific Antibody Reactivity

Contact Info

Product

Resources

About