The extracellular matrix molecules versican and hyaluronan in urethral and vaginal tissues in stress urinary incontinence

Harten, Ingrid A.; Evanko, Stephen P.; Choe, Chong; Lee, Eugene W.; Patel, Bhavin; Bogdani, Marika; Wight, Thomas N.; Lee, Una

doi:10.1002/nau.24635

Cited by 6 publications

(2 citation statements)

References 27 publications

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“…SUI is a common disease affecting women. It reportedly results from an imbalance of ECM remodeling in the urethra and anterior vaginal 26,29 . ECM reconstruction is mainly regulated by broblasts present in the pelvic oor 30 .…”

Section: Discussionmentioning

confidence: 99%

Application of estrogen for the treatment of stress urinary incontinence in mice

Hong

et al. 2022

Arch Gynecol Obstet

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Background The etiology of stress urinary incontinence (SUI) is complex and diverse among women, with past studies having demonstrated that estrogen de ciency is an important cause of pelvic oor muscle atrophy and urethral degeneration. We comprehensively investigated the effects of estrogen in the treatment of SUI in female mice at cellular and animal levels.Methods L929 cell mechanical injury model was established by four point bending device, and SUI mouse model was established by vaginal dilation method commonly used to simulate labor injury. After treatment, the expressions of collagen I, collagen III, elastin, TIMP-1, TIMP-2, MMP-2 and MMP-9 were detected, the leak point pressure (LPP) and abdominal leak point pressure (ALPP) of mice in each group were detected, and the effect of estrogen on extracellular matrix remodeling of mouse urethra and anterior vaginal wall was observed from the histological level.Results These results revealed that an appropriate amount of estrogen can promote the expression of collagen I, collagen III, elastin, TIMP-1, and TIMP-2, decrease the expression of MMP-2 and MMP-9, and maintain the dynamic balance of MMPs/TIMPs at both cellular and animal levels. Meanwhile, we determined that estrogen can increase the LPP and ALPP values of SUI mice. The collagen bers' content in the mice treated with estrogen was signi cantly greater than in the control group mice.Conclusions The estrogen may alleviate the symptoms of SUI by reconstituting ECM, toward laying a solid foundation for the further exploration of estrogen therapy.

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Section: Discussionmentioning

confidence: 99%

Application of estrogen for the treatment of stress urinary incontinence in mice

Hong

et al. 2022

Arch Gynecol Obstet

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“…Hyaluronic acid (HA), a non-sulfated glycosaminoglycan, is an essential component of connective, epithelial, and neural tissues [ 12 ]. Its strong water-binding properties provide both lubricating and moisturizing effects, which contribute to maintaining a proper level of hydration and viscoelasticity in several body parts, including the urinary tract and genital tissues [ 13 ]. Endocrine changes associated with menopause bring about several consequences for urogenital tissues, including reduced synthesis of HA and mucopolysaccharides in the extracellular matrix (ECM) [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid: A Valid Therapeutic Option for Early Management of Genitourinary Syndrome of Menopause in Cancer Survivors?

et al. 2022

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Genitourinary syndrome of menopause (GSM) is a chronic condition affecting a large number of women, with a major impact on their urogenital health and sexual function. It occurs at midlife because estrogen levels decline with menopause enhancing aging-related changes of the functional anatomy of the urogenital system. Unfortunately, GSM may occur early in the lifespan of women or be exacerbated following anticancer treatments, such as chemotherapy, ionizing radiation, or surgical removal of reproductive organs. Symptoms of GSM are often under-reported by women, under-estimated and under-diagnosed by health care providers (HCPs), and subsequently under-treated, despite their profound negative impact on the quality of life. The mainstay of vaginal treatments is local estrogen therapy (LET) ensuring an effective management of moderate to severe symptomatic GSM. However, LET is generally contraindicated in women with a history of hormone receptor positive cancer, due to the fear of increased recurrence or possible interference with endocrine adjuvant therapies. Among non-hormonal treatments, hyaluronic acid-based moisturizers have shown promising clinical results both in healthy women and in cancer patients or survivors. Its strong water-binding properties provide lubricating and moisturizing effects, which contribute to maintaining a proper level of hydration and viscoelasticity in several body parts, including the urinary tract and genital tissues. Hyaluronic acid-based moisturizers are effective, safe, and well tolerated; therefore, they may represent a valid option for the early management of GSM-associated symptoms in every woman with a history of cancer who is unable or unwilling to undergo hormone-based therapies. Hence, the aim of this review was to provide an overview of GSM etiology and treatment in women with natural or iatrogenic menopause, with a focus on the use of hyaluronic acid as a prophylactic treatment in the context of an integrated management protocol for cancer patients.

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Urethral tissue characterization using multiparametric ultrasound imaging

Tai,

Kalayeh,

Ashton-Miller

et al. 2025

Ultrasonics

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The extracellular matrix molecules versican and hyaluronan in urethral and vaginal tissues in stress urinary incontinence

Cited by 6 publications

References 27 publications

Application of estrogen for the treatment of stress urinary incontinence in mice

Application of estrogen for the treatment of stress urinary incontinence in mice

Hyaluronic Acid: A Valid Therapeutic Option for Early Management of Genitourinary Syndrome of Menopause in Cancer Survivors?

Urethral tissue characterization using multiparametric ultrasound imaging

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