The factors effecting thrombocyte function tests

Abstract

Fizyolojik koşullarda sirkülasyondaki trombositlerin görevi bir damar hasarı oluştuğunda kan kaybını engellemektir. Subendotele trombosit-trombosit adezyonunu sağlayan ve hasara uğramış damar duvarında geçici olarak "trombosit tıkacı" oluşturan bu sistem ateroskleroz veya arterial tromboz gibi patolojik şartlarda ise lokal iskemiye veya aterosklerotik lezyona sebep olmaktadır. Klinik çalışmalarda temel alınan trombosit fonksiyon testleri trombositlerin agonistlere olan duyarlığı ve oluşan trombosit cevabındaki spesifiklik açısından öneme sahiptir. Bu çalışmada trombosit fonksiyon testlerini etkileyen parametreler, yapılmış çalışmalarla karşılaştırmalı olarak incelenmiştir.

Disseminated Intravascular Coagulopathy; a Condition to Monitor in the Management of Leukaemia Patients

“…Also, about 9% of the studied population have prolonged PT, PTTK, INR, increased D-dimer level and thrombocytopenia establishing the onset of DIC symptoms which is evidenced by some bleeding episodes experienced by the patients. This observation is corroborated by a study that ascertained the prolonged PT/PTTK and D-dimer as diagnostic tools for DIC [10].…”

“…DIC is a dynamic process and the analysis performed shows only the conditions at a given moment in time [10]. In clinical conditions associated with DIC, repeating the tests performed initially helps in establishing the diagnosis.…”

“…In clinical conditions associated with DIC, repeating the tests performed initially helps in establishing the diagnosis. Analysis performed in assessing the haemostatic state give information about the clinical course and the diagnosis is established based on clinical suspicion and supportive laboratory analysis [10]. These assessment analyses include laboratory parameters indicative of procoagulant and fibrinolytic substance activation, inhibitor consumption and organ damage or failure [11].…”

Disseminated Intravascular Coagulation in Obstetrics: Ethiopathogenesis and up to date Management Strategies

“…Tests used in assessing the hemostatic state provide information about the clinical course. Prothrombin time (PT), activated partial thromboplastin (aPTT) and thrombocyte count reflect the consumption and activation of thrombocytes (40) .…”