The factors of dysregualtion of the immune response (at different stage of its implementation) in patients with pulmonary tuberculosis

Георгиевна, Чурина Елена; Ивановна, Уразова Ольга; Викторович, Новицкий Вячеслав; Евгеньевна, Есимова Ирина; Евгеньевна, Кононова Татьяна; Владимировна, Филинюк Ольга; Владимировна, Колобовникова Юлия; Ивановна, Дмитриева Алла

doi:10.20538/1682-0363-2016-5-166-177

Cited by 6 publications

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References 6 publications

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“…С другой стороны, Mtb обладают свойствами, подавляющими М1-поляризацию макрофагов. Экспрессия scavenger-рецепторов на М2-макрофагах оказывает модулирующее влияние на дифференцировку Т-лимфоцитов, способствует диссеминации Mtb (при развитии Th2-иммунного ответа) и патологическому ремоделированию легочной ткани, ее фиброзу (при развитии Treg-иммунного ответа) [30,75,76].…”

Section: макрофаги и микобактериальная инфекция механизмы ускользаниunclassified

Macrophages in bacterial lung diseases: phenotype and functions (review)

et al. 2019

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This literature review is devoted to the analysis of the role of macrophages in the immunopathogenesis of infectious lung diseases of bacterial etiology. The article summarizes information about the origin of macrophages, their phenotypic and functional heterogeneity. The mechanisms of impaired protective function of innate immunity are associated with the polarization of the program of maturation and activation of macrophages in the direction to tolerogenic or immunoregulatory cells with phenotype of M2. Alveolar macrophages perform a variety of functions (from pro-inflammatory to regenerative) in the development of inflammation in the respiratory organs. Their inherent plasticity suggests that the same macrophages can change their phenotype and function depending on the microenvironment in the inflammatory focus at different stages of the disease. Understanding the mechanisms that regulate macrophage plasticity will be an important step towards realizing the potential of personalized immunomodulatory therapy.

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Section: макрофаги и микобактериальная инфекция механизмы ускользаниunclassified

Macrophages in bacterial lung diseases: phenotype and functions (review)

et al. 2019

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Effects of Levofloxacin on Blood Lymphocyte Apoptosis in Patients with Pulmonary Tuberculosis: an In Vitro Study

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Notch signaling pathway in the development of imbalanced immune responses in patients with disseminated pulmonary tuberculosis

Sanina,

Serebryakova,

Urazova

et al. 2024

Bûll. sib. med.

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Aim. To determine the role of the Notch signaling pathway in the regulation of Th1 / Th2 lymphocyte balance in patients with disseminated drug-sensitive (DS) and drug-resistant (DR) pulmonary tuberculosis (PT).Materials and methods. Mononuclear leukocytes were isolated from the venous blood of 13 patients with disseminated PT by density gradient centrifugation. The cells were cultured for 72 h in the complete cell culture medium at 5% CO2 and 37 °C. Preliminarily, CFP10 and ESAT6 mycobacterial antigens or γ-secretase inhibitor DAPT (5 μM / l; 10 μM / l) together with CFP10 and ESAT6 antigens were added to the culture medium. Immunophenotyping of Th1 and Th2 lymphocytes was performed by multicolor flow cytometry by determining the expression of CD4 receptor and intracellular transcription factors T-bet and GATA-3.Results. In patients with disseminated DS and DR PT, an increase in the number of Th1 and Th2 lymphocytes was found in intact cultures. Stimulation of cells with mycobacterial antigens CFP10 and ESAT6 resulted in an increase in the number of CD4+T-bet+ and CD4+GATA-3+ cells in all comparison groups. Addition of CFP10 and ESAT6 antigens and DAPT (10 μM / l) to the incubation medium was accompanied by a decrease in the number of Th2 lymphocytes in PT patients in both groups. A rise in the number of Th1 cells was registered only in patients with DS PT. Suppression of the Notch signaling pathway with the γ-secretase inhibitor DAPT (10 μM / l) resulted in an increase in the Th1 / Th2 lymphocyte balance in both DS and DR variants of the disease.Conclusion. The Notch signaling pathway has a modulating effect on the differentiation of the key lymphocyte populations that determine the balance between cell-mediated and humoral immune responses to PT. Suppression of the Notch signaling cascade by the γ-secretase inhibitor DAPT (10 μM / l) in vitro promotes an increase in the Th1 / Th2 ratio in patients with disseminated DS and DR PT. The positive regulatory effect on the Th1 / Th2 lymphocyte balance allows to consider the Notch signaling pathway as a promising potential target in the development of new approaches to the pathogen-specific therapy for PT.

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The factors of dysregualtion of the immune response (at different stage of its implementation) in patients with pulmonary tuberculosis

Cited by 6 publications

References 6 publications

Macrophages in bacterial lung diseases: phenotype and functions (review)

Macrophages in bacterial lung diseases: phenotype and functions (review)

Effects of Levofloxacin on Blood Lymphocyte Apoptosis in Patients with Pulmonary Tuberculosis: an In Vitro Study

Notch signaling pathway in the development of imbalanced immune responses in patients with disseminated pulmonary tuberculosis

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