The faecal metabolome and mycobiome in Parkinson's disease

Pablo-Fernández, Eduardo De; Gebeyehu, Gerum Gashaw; Flain, Luke; Slater, Rachael; Frau, Alessandra; Ijaz, Umer Zeeshan; Warner, Thomas T.; Probert, Chris

doi:10.1016/j.parkreldis.2022.01.005

Cited by 19 publications

(8 citation statements)

References 24 publications

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“…The results of our bibliometric analysis also showed that targeted dietary SCFAs may be a mechanism to alter immune profiles, promote immune tolerability, and enhance glucose control for the therapy of T1D [ 69 ]. In addition, patients with IBD and PD all exhibited abnormal of SCFAs level in fecal [ 70 – 72 ]. All the above indicated that, SCFAs play a major role in metabolic and neurological disorders.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive bibliometric and visualized analysis of research on fecal microbial transplantation published from 2000 to 2021

Chen

et al. 2022

BioMed Eng OnLine

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Background Fecal microbial transplantation has emerged in recent years as a method of treating disease by rebuilding the intestinal flora. However, few bibliometric analyses have systematically studied this area of research. We aimed to use bibliometric analysis to visualize trends and topical research in fecal microbial transplantation to help provide insight into future trends in clinical and basic research. Materials and methods Articles and reviews related to fecal microbial transplantation were collected from the Web of Science Core Collection. Significant information associated with this field was visually analyzed by using Biblioshiny and CtieSpace software. Results A total of 3144 articles and overviews were included. The number of publications related to fecal microbial transplantation significantly increased yearly. These publications mainly came from 100 countries, led by the US and China, and 521 institutions. The most prolific and influential author is KHORUTS A. The main disciplines and application fields of fecal microbial transplantation included molecular /biology/immunology and medicine/clinical medicine, and the research foundation of fecal microbial transplantation was molecular /biology/genetics and health/nursing/medicine. An alluvial flow visualization showed several landmark articles. New developments were identified in terms of reference and keyword citation bursts. Data analysis showed that different FMT preparation and delivery methods gradually appeared as research hotspots. The main research keywords in the last 3 years were chain fatty acids, Akkermansia muciniphila, and insulin sensitivity, other keywords were current and developing research fields. Conclusion Research on fecal microbial transplantation is flourishing and many new applications of fecal microbial transplantation are emerging. Microbial metabolites such as short-chain fatty acids and the microbiota–gut–brain axis have become the focus of current research and are future research trends.

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Section: Discussionmentioning

confidence: 99%

Comprehensive bibliometric and visualized analysis of research on fecal microbial transplantation published from 2000 to 2021

Chen

et al. 2022

BioMed Eng OnLine

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“…The metabolism of short-chain fatty acids (SCFAs), such as valeric acid [34,40,41] and butyric acid [39,42,40,41], has been reported to be changed in the plasma and faeces of PD patients. SCFAs are the primary metabolites produced from dietary fibre by the fermentation of gut bacteria; they have part of the effects on maintaining intestinal barrier integrity and gut mucosal immunity [40].…”

Section: Significant Pathways Of Matched Metabolitesmentioning

confidence: 99%

Identification of metabolites reproducibly associated with Parkinson’s Disease via meta-analysis and computational modelling

Fleming

Luo

Liu

et al. 2023

Preprint

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Many studies have reported metabolomic analysis of different bio-specimens from Parkinson’s disease patients. However, inconsistencies in reported metabolite concentration changes make it difficult to draw conclusions as to the role of metabolism in the occurrence or development of Parkinson’s disease. We reviewed the literature on metabolomic analysis of Parkinson’s disease patients. From 74 studies that passed quality control metrics, perturbations to 928 metabolites were reported to be associated with PD diagnosis, but only 190 were replicated with the same changing trends in more than one study. Of these metabolites, 60 exclusively increased, such as 3-methoxytyrosine and glycine, 54 exclusively decreased, such as pantothenic acid and caffeine, and 76 inconsistently changed in concentration in PD versus control subjects, such as ornithine and tyrosine. A novel genome-scale metabolic model of PD and corresponding metabolic map linking most of the replicated metabolites enabled a better understanding of the dysfunctional pathways of PD and prediction of additional potential metabolic markers from pathways with consistent metabolite changes to target in future studies.

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“…A modified gut mycobiome composition was shown in numerous conditions: inflammatory bowel disease [ 81 ], irritable bowel syndrome [ 82 ], colorectal cancer [ 57 ], obesity [ 31 , 33 ], alcoholic liver disease [ 83 ], diabetes type I and II [ 79 , 84 , 85 , 86 ], multiple sclerosis [ 78 , 87 ], chronic kidney disease [ 88 ], atopic dermatitis [ 89 ], Parkinson’s disease [ 90 ], schizophrenia [ 91 ], etc. Moreover, correlations of fungal taxa with innate and adaptive immunity, e.g., effector CD4+ T cells and CD8+ T cells, memory CD4+ T cells, NK cells, regulatory B cells and other proinflammatory cytokines, were observed [ 78 , 92 ].…”

Section: Gut Mycobiomementioning

confidence: 99%

The Human Mycobiome: Colonization, Composition and the Role in Health and Disease

Belvončíková

Šplíchalová

Vídeňská

et al. 2022

JoF

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The mycobiome is the fungal component of the human microbial ecosystem that represents only a small part of this environment but plays an essential role in maintaining homeostasis. Colonization by fungi begins immediately after birth. The initial mycobiome is influenced by the gestational age of a newborn, birth weight, delivery method and feeding method. During a human’s life, the composition of the mycobiome is further influenced by a large number of endogenous and exogenous factors. The most important factors are diet, body weight, age, sex and antibiotic and antifungal therapy. The human mycobiome inhabits the oral cavity, gastrointestinal tract, respiratory tract, urogenital tract and skin. Its composition can influence the gut–brain axis through immune and non-immune mediated crosstalk systems. It also interacts with other commensals of the ecosystem through synergistic and antagonistic relationships. Moreover, colonization of the gut by opportunistic fungal pathogens in immunocompromised individuals can lead to clinically relevant disease states. Thus, the mycobiome represents an essential part of the microbiome associated with a variety of physiological and pathological processes. This review summarizes the current knowledge on the composition of the mycobiome in specific sites of the human body and its role in health and disease.

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The faecal metabolome and mycobiome in Parkinson's disease

Cited by 19 publications

References 24 publications

Comprehensive bibliometric and visualized analysis of research on fecal microbial transplantation published from 2000 to 2021

Comprehensive bibliometric and visualized analysis of research on fecal microbial transplantation published from 2000 to 2021

Identification of metabolites reproducibly associated with Parkinson’s Disease via meta-analysis and computational modelling

The Human Mycobiome: Colonization, Composition and the Role in Health and Disease

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