The Failure of Normal Haemopoiesis in Rats during the Development of Acute Leukaemia

Hoelzer, Dieter; Harriss, E. B.

doi:10.1159/000208383

Cited by 18 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ph‐positive stem cells are, however, assumed to be resistant to this feedback regulation. This assumption is consistent with studies of the growth of CML progenitor cells in cultures and is also consistent with the results of studies of leukemia in animal models [18].…”

Section: Methodssupporting

confidence: 91%

Relapse in Chronic Myeloid Leukemia after Bone Marrow Transplantation: Biomathematical Modeling as a New Approach to Understanding Pathogenesis

et al. 1999

View full text Add to dashboard Cite

show abstract

Section: Methodssupporting

confidence: 91%

Relapse in Chronic Myeloid Leukemia after Bone Marrow Transplantation: Biomathematical Modeling as a New Approach to Understanding Pathogenesis

et al. 1999

View full text Add to dashboard Cite

show abstract

“…In a group of animals investigated under the same conditions as described here [6] it was found that the number of platelets declined to about one tenth of normal value 6 days after transfusion of LC. The bleeding may be fur ther due to disorders of hemostasis known to develop during the course of this leukemia [7J.…”

Section: Discussionsupporting

confidence: 53%

Involvement of the Central Nervous System in Rats with Acute Leukemia L 5222

Calvo¹,

Hoelzer²

1976

Acta Haematol

Self Cite

View full text Add to dashboard Cite

Young adult BD-IX rats made leukemic by intravenous infusion of 2×10^τ nucleated blood cells from leukemic donors (L 5222), showed lesions in the central nervous system 6 days after transfer when their leukocyte count was between 250,000 and 350,000 cells/μl. The brain was affected in only half of the animals, whereas all showed an infiltration of the meninges. Furthermore, all animals had extensive lesions in the spinal cord. The lesions consisted of nodules of leukemic cells and hemorrhages which were predominant in the lower half of the spinal cord and more abundant in the white than in the gray matter. Paraplegia appeared in some animals shortly before death. Since there is a consistent involvement of the meninges and spinal cord, the L 5222 leukemia seems to be a useful model for the study of leukemic infiltration of the central nervous system and the reaction to chemotherapy.

show abstract

“…Rats of both sexes from the inbred BD IX strain (Druckrey, 1971) and the acute leukaemia L 5222 (Hoelzer, 1973;Hoelzer et al, 1973) were used. Following a dose of lo7 cells, as used in these experiments, survival time is 6-7 days.…”

Section: A T E R I a L S A N D M E T H O D S Animals And Leukaemiamentioning

confidence: 99%

Stem Cell Kinetics in the L 5222 Rat Leukaemia

1974

Self Cite

View full text Add to dashboard Cite

The behaviour of normal haemopoietic stem cells of the bone marrow during the development of the acute transferable rat leukaemia, L 5222, has been investigated. The granulopoietic committed stem cells, measured by the in vitro colony technique, showed a marked decrease to less than half normal levels. Pluripotent stem cells included in the small lymphocytes of the bone marrow, and labelled with 3Hthymidine by the complete labelling method, showed only a modest decrease in number and an unchanged labelling intensity. The results suggest that in this leukaemia the pluripotent stem cells may be affected in such a way that they are unable to react by proliferation to the depletion of the succeeding cell compartments. This might be due to inhibition by leukaemic cells or to a disturbed feedback regulation between the committed and pluripotent stem cell compartments.

show abstract

The Failure of Normal Haemopoiesis in Rats during the Development of Acute Leukaemia

Cited by 18 publications

References 6 publications

Relapse in Chronic Myeloid Leukemia after Bone Marrow Transplantation: Biomathematical Modeling as a New Approach to Understanding Pathogenesis

Relapse in Chronic Myeloid Leukemia after Bone Marrow Transplantation: Biomathematical Modeling as a New Approach to Understanding Pathogenesis

Involvement of the Central Nervous System in Rats with Acute Leukemia L 5222

Stem Cell Kinetics in the L 5222 Rat Leukaemia

Contact Info

Product

Resources

About