The Fast Inhibitor of Tissue Plasminogen Activator in Plasma During Pregnancy

Wiman, Björn; Csemiczky, G.; Marsk, L; Robbe, Hjördis

doi:10.1055/s-0038-1661154

Cited by 71 publications

(26 citation statements)

References 3 publications

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“…Especially the increasing levels of plasminogen activator inhibitor-1 and a 2 -antiplasmin äs well äs the decreasing tissue plasminogen activator levels are however not sufficient to impair the actual fibrinolytic activity, äs can be concluded from the steadily increasing concentrations of the D-dimers. It therefore remains questionable äs to whether the combination of results allows the conclusion that the fibrinolytic activity decreases, leading to a thrombotic tendency during prengnancy, äs stated earlier (13). The results reported here indicate a shift of coagulation and fibrinolysis during normal pregnancy.…”

Section: Discussionmentioning

confidence: 51%

“…More recent studies show that the plasminogen activator inhibitor also steadily increases throughout pregnancy (13,14), whereas a special elevation is seen in pre-eclampsia (15,16). Recently several new tests became available both for the investigation of coagulation activation and for the assessment of the level of fibrinolytic parameters.…”

Section: Introductionmentioning

confidence: 99%

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Blood Coagulation and Fibrinolysis During Normal Pregnancy

Wersch¹,

Ubachs²

1991

Clinical Chemistry and Laboratory Medicine

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Summary: Fifty-six pregnant women (gestational age 6-40 weeks) were evaluated for their coagulation activation (fibrin monomers and thrombin-antithrombin III complex) and for their fibrinolysis profile by determining tissue plasminogen activator, plasminogen activator inhibitor, plasminogen, a 2 -antiplasmin-and D-dimer. Fibrin monomers and thrombin-antithrombin III complexes were found to be significantly increasing with gestational age. All the fibrinolytic parameters showed a steady growth with the progress of the pregnancy, with the exception of tissue plasminogen activator which showed a significant decrease with gestational age, but mainly within the reference ränge. These results suggest a Stimulation of the coagulation System and an activation of fibrinolysis with ongoing pregnancy, although the increasing oc 2 -antiplasmin and plasminogen levels and the decreasing tissue plasminogen activator concentrations do not conform to this trend.

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Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Blood Coagulation and Fibrinolysis During Normal Pregnancy

Wersch¹,

Ubachs²

1991

Clinical Chemistry and Laboratory Medicine

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“…Also, the factor VII and fibrinogen levels have been reported to be elevated after contraceptive pill use in women 17 and the factor VII level to be increased about 15-fold in late pregnancy. 49 With the strong correlation of E/T with insulin in men noted previously, 1 -5 it is not surprising that risk factors for CHD that correlate with the sex hormones also correlate with insulin. Thus, others have suggested insulin as the underlying factor linking these risk factors.…”

Section: Resultsmentioning

confidence: 76%

Relation of hemostatic risk factors to other risk factors for coronary heart disease and to sex hormones in men.

Yang

Jing

Resnick

et al. 1993

Arterioscler Thromb

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The present study was carried out to explore the possible relation of plasma plasminogen activator inhibitor-1 (PAI-1), fibrinogen, and factor VII levels to other risk factors for coronary heart disease (CHD) and to serum sex hormone levels. The study group comprised 48 apparently healthy men. To avoid the confounding factor of obesity, correlations were determined in the 30 men in this group with a body mass index (BMI) <26.4, after controlling for age. PAI-1 correlated with testosterone, estradiol/ testosterone, and free testosterone/testosterone (FT/T), and fibrinogen correlated with FT/T. All three hemostatic factors correlated with glucose and with the ratio of cholesterol/high density lipoprotein cholesterol, while PAI-1 correlated with diastolic blood pressure. To test the effect of obesity, correlations were determined in the entire group of 48 men, which included 18 subjects with a BMI >26.4. All three hemostatic factors correlated with BMI in this group after controlling for age; however, on controlling for testosterone, only PAI-1 correlated with BMI. Fibrinogen correlated with age in both groups after controlling for testosterone or BMI. These correlations support the hypothesis that PAI-1, fibrinogen, and factor Vn are related to other risk factors for CHD and that an alteration in the sex hormone milieu may be the underlying factor linking them. {Arteriosclerosis and Thrombosis 1993;13:467-471) KEY WORDS • sex hormones • estradiol • testosterone • plasminogen activator inhibitor-1 • fibrinogen • factor VII

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“…This discrepancy may be due to fundamental genetic differences between Japanese and Caucasians. Increased plasma levels of total plasminogen activator inhibitor (PAI) activity in preeclampsia have been noted for more than a decade (Wiman et al 1984;de Boer et al 1988;Gilabert et al 1990). Plasma total PAI activity is mostly PAI-1 activity.…”

Section: Discussionmentioning

confidence: 99%

The 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene is associated with severe preeclampsia

et al. 2000

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Preeclampsia is associated with thrombosis of the intervillous or spiral artery. A deletion/insertion polymorphism (4G or 5G) in the promoter of the plasminogen activator inhibitor type 1 (PAI-1) gene is suggested to be involved in regulating the synthesis of the inhibitor, 4G allele, being associated with the enhanced gene expression and plasma PAI-1 levels. We assessed the association between preeclampsia and the 4G/5G polymorphism of the PAI-1 gene in 115 preeclamptic patients, 210 pregnant controls, and 298 healthy volunteer controls. The frequency of the homozygotes for the 4G allele was significantly higher in the patients than in the control pregnant women (P ϭ 0.04) or in the healthy volunteers (P ϭ 0.02). The 4G allele frequency was also significantly higher in the patients than in the control group of pregnant women (P ϭ 0.03) and in the healthy volunteers (P ϭ 0.02). These results suggest that the presence of the 4G/4G genotype of the PAI-1 gene is one of the risk factors for preeclampsia.

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The Fast Inhibitor of Tissue Plasminogen Activator in Plasma During Pregnancy

Cited by 71 publications

References 3 publications

Blood Coagulation and Fibrinolysis During Normal Pregnancy

Blood Coagulation and Fibrinolysis During Normal Pregnancy

Relation of hemostatic risk factors to other risk factors for coronary heart disease and to sex hormones in men.

The 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene is associated with severe preeclampsia

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