The fasting hyperglycaemia study: II. Randomized controlled trial of reinforced healthy-living advice in subjects with increased but not diabetic fasting plasma glucose

Dyson, Pamela; Hammersley, M S; Morris, R J; Holman, Rury R.; Turner, R. C.

doi:10.1016/s0026-0495(97)90318-8

Cited by 58 publications

(21 citation statements)

References 16 publications

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“…The recent STOP-NIDDM trial showed a 49% risk reduction in CVD events in IGT patients treated with acarbose [47]. The British Fasting Hyperglycaemia Study did not show any benefit on the development of diabetes with lifestyle change among subjects with IFG [48]. In relation to screening for diabetes, the epidemiological data in combination with the clinical trials suggest that 2-h PG has a stronger prognostic implication than FPG, although both are highly correlated.…”

Section: Discussionmentioning

confidence: 99%

Hyperglycaemia and mortality from all causes and from cardiovascular disease in five populations of Asian origin

2004

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Section: Discussionmentioning

confidence: 99%

Hyperglycaemia and mortality from all causes and from cardiovascular disease in five populations of Asian origin

2004

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“…To date there has been a dearth of evidence concerning T2DM prevention in the UK, with small-scale projects showing mixed results. (7)(8)(9)(10) This study assesses whether the Let's Prevent T2DM programme is effective at preventing progression to T2DM in people with PDM identified through a systematic screening pathway within primary care. Let's Prevent is a pragmatic, relatively low resource, group-based structured-education programme targeting lifestyle behaviour change specifically designed for implementation within a community setting.…”

Section: Usa Diabetes Prevention Program (Dpp)(6)mentioning

confidence: 99%

A community based primary prevention programme for type 2 diabetes integrating identification and lifestyle intervention for prevention: the Let's Prevent Diabetes cluster randomised controlled trial

Davies

Gray

Troughton

et al. 2016

Preventive Medicine

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Aims: Prevention of type 2 diabetes (T2DM) is a priority in healthcare, but there is a lack of evidence investigating how to effectively translate prevention research into a UK primary care setting. We assessed whether a structured education programme targeting lifestyle and behaviour change was effective at preventing progression to T2DM in people with prediabetes.. Materials and methods:44 General Practices were randomised to receive either standard care or a six hour group structured education programme with an annual refresher course, and regular phone contact. Participants were followed up for 3 years. The primary outcome was progression to T2DM.Results: Eight hundred and eighty participants were included (36% female, mean age 64 years, 16% ethnic minority group); 131 participants developed T2DM. There was a nonsignificant 26% reduced risk of developing T2DM in the intervention arm compared to standard care (HR 0.74, 95%CI 0.48, 1.14, p=0.18). The reduction in T2DM risk when excluding those who did not attend the initial education session was also non-significant (HR 0.65, 0.41, 1.03, p=0.07). There were statistically significant improvements in HbA1c (-0.06, -0.11, -0.01), LDL cholesterol (-0.08, -0.15, -0.01), sedentary time (-26.29, -45.26, -7.32) and step count (498.15, 162.10, 834.20) when data were analysed across all time points. Conclusions:This study suggests that a relatively low resource, pragmatic diabetes prevention programme resulted in modest benefits to biomedical, lifestyle and psychosocial outcomes, however the reduction to the risk of T2DM did not reach significance. The findings have important implications for future research and primary care.Trial Registration: ISRCTN80605705

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“…154,155 (1+) These results have been repeated to a lesser, but also signifi cant, degree in more adherent subjects or more intensive programmes. 183,469,477,478,533 In one study there was a strong inverse correlation between progression to diabetes and the degree that intervention goals were achieved.…”

Section: Intensity Of Interventionmentioning

confidence: 99%

Absolute risk of cardiovascular disease events, and blood pressure‐ and lipid‐lowering therapy in Australia

Banks

Crouch

Korda

et al. 2016

Medical Journal of Australia

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Objective: To quantify absolute cardiovascular disease (CVD) risk and treatment in Australian adults. Design, participants: Cross‐sectional representative study of 9564 people aged 18 years or more who had participated in the 2011–12 Australian National Health Measures Survey (response rate for those aged 45–74 years: 46.5%). Main outcome measures: Prior CVD was ascertained and 5‐year absolute risk of a primary CVD event calculated (using the Australian National Vascular Disease Prevention Alliance algorithm; categories: low [< 10%], moderate [10–15%], and high [> 15%] risk) on the basis of data on medical history, risk factors and medications, derived from interviews, physical measurements, and blood and urine samples. Results: Absolute CVD risk increased with age and was higher among men than women. Overall, 19.9% (95% CI, 18.5–21.3%) of Australians aged 45–74 years had a high absolute risk of a future CVD event (an estimated 1 445 000 people): 8.7% (95% CI, 7.8–9.6%) had prior CVD (estimated 634 000 people) and 11.2% (95% CI, 10.2–12.2%) had high primary CVD risk (estimated 811 000 people). A further 8.6% (95% CI, 7.4–9.8%, estimated 625 000) were at moderate primary CVD risk. Among those with prior CVD, 44.2% (95% CI, 36.8–51.6%) were receiving blood pressure‐ and lipid‐lowering medications, 35.4% (95% CI, 27.8–43.0%) were receiving only one of these, and 20.4% (95% CI, 13.9–26.9%) were receiving neither. Corresponding figures for high primary CVD risk were 24.3% (95% CI, 18.3–30.3%); 28.7% (95% CI, 22.7–34.7%); and 47.1% (95% CI, 39.9–54.3%). Conclusions: About one‐fifth of the Australian population aged 45–74 years (about 1.4 million individuals) were estimated to have a high absolute risk of a future CVD event. Most (estimated 970 000) were not receiving currently recommended combination blood pressure‐ and lipid‐lowering therapy, indicating substantial potential for health gains by increasing routine assessment and treatment according to absolute CVD risk.

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The fasting hyperglycaemia study: II. Randomized controlled trial of reinforced healthy-living advice in subjects with increased but not diabetic fasting plasma glucose

Cited by 58 publications

References 16 publications

Hyperglycaemia and mortality from all causes and from cardiovascular disease in five populations of Asian origin

Hyperglycaemia and mortality from all causes and from cardiovascular disease in five populations of Asian origin

A community based primary prevention programme for type 2 diabetes integrating identification and lifestyle intervention for prevention: the Let's Prevent Diabetes cluster randomised controlled trial

Absolute risk of cardiovascular disease events, and blood pressure‐ and lipid‐lowering therapy in Australia

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