The fate and oxidative stress of different sized SiO2 nanoparticles in zebrafish (Danio rerio) larvae

Zhu, Biran; He, Wei; Hu, Shengchao; Kong, Ren; Yang, Lihua

doi:10.1016/j.chemosphere.2019.03.091

Cited by 55 publications

(15 citation statements)

References 31 publications

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“…68 and 69) and SiO 2 . 70 The increased expression of cat due to nP exposure also supports the developmental deformities observed in zebrafish embryos from this NM treatment. This indicates that the teratogenicity of nP can be due to the upregulated cat expressions to combat increased oxidative stress.…”

Section: Discussionsupporting

confidence: 58%

Exposure to biogenic phosphorus nano-agromaterials promotes early hatching and causes no acute toxicity in zebrafish embryos

Priyam

Singh

Afonso

et al. 2022

Environ. Sci.: Nano

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Section: Discussionsupporting

confidence: 58%

Exposure to biogenic phosphorus nano-agromaterials promotes early hatching and causes no acute toxicity in zebrafish embryos

Priyam

Singh

Afonso

et al. 2022

Environ. Sci.: Nano

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“…It is likely that the accumulation of AMS-6 particles at higher doses was the cause of the increase in ROS production as observed in Supplementary Figure S7e and consequently contributed to the production of oxidative stress resulting in increased fish death. This is also consistent with previous findings, where zebrafish exposed to high concentrations of MSPs (>100 μg/mL) resulted in higher penetration and biodistribution of the particles, increased ROS production, reduction in antioxidant enzyme activity and altered gene expression [ 79 , 80 ]. Notably, PB mitigated the effects of mesoporous silica.…”

Section: Resultssupporting

confidence: 93%

Enhanced Antioxidant Effects of the Anti-Inflammatory Compound Probucol When Released from Mesoporous Silica Particles

et al. 2022

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Brain endothelial cells mediate the function and integrity of the blood brain barrier (BBB) by restricting its permeability and exposure to potential toxins. However, these cells are highly susceptible to cellular damage caused by oxidative stress and inflammation. Consequent disruption to the integrity of the BBB can lead to the pathogenesis of neurodegenerative diseases. Drug compounds with antioxidant and/or anti-inflammatory properties therefore have the potential to preserve the structure and function of the BBB. In this work, we demonstrate the enhanced antioxidative effects of the compound probucol when loaded within mesoporous silica particles (MSP) in vitro and in vivo zebrafish models. The dissolution kinetics were significantly enhanced when released from MSPs. An increased reduction in lipopolysaccharide (LPS)-induced reactive oxygen species (ROS), cyclooxygenase (COX) enzyme activity and prostaglandin E2 production was measured in human brain endothelial cells treated with probucol-loaded MSPs. Furthermore, the LPS-induced permeability across an endothelial cell monolayer by paracellular and transcytotic mechanisms was also reduced at lower concentrations compared to the antioxidant ascorbic acid. Zebrafish pre-treated with probucol-loaded MSPs reduced hydrogen peroxide-induced ROS to control levels after 24-h incubation, at significantly lower concentrations than ascorbic acid. We provide compelling evidence that the encapsulation of antioxidant and anti-inflammatory compounds within MSPs can enhance their release, enhance their antioxidant effects properties, and open new avenues for the accelerated suppression of neuroinflammation.

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“…Similar to oxidative stress caused by mSiNPs in many organisms, − we found that excessive ROS production happened in nematodes treated with mSiNPs at concentrations over 300 and 3000 μg/L SiNPs. Acute and prolonged exposure to 3000 μg/L mSiNPs and SiNPs also increased expression levels of genes associated with oxidative stress in nematodes, and the capability of SiNPs causing oxidative stress is slightly stronger than mSiNPs.…”

Section: Discussionsupporting

confidence: 63%

Mesoporous Silica Nanoparticles at Predicted Environmentally Relevant Concentrations Cause Impairments in GABAergic Motor Neurons of Nematode Caenorhabditis elegans

Li¹,

Wang

Cheng³

et al. 2020

Chem. Res. Toxicol.

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Available safety evaluations regarding mesoporous silica nanoparticles (mSiNPs) are based on the assumption of a relatively high exposure concentration, which makes the findings less valuable in a realistic environment. In this study, we employed Caenorhabditis elegans (C. elegans) as a model to assess the neuronal damage caused by mSiNPs at the predicted environmentally relevant concentrations. After nematodes were acute and prolonged exposed to mSiNPs at concentrations over 300 μg/L, locomotion degeneration, shrinking behavior, and abnormal foraging behavior were observed, which were associated with the deficits in the development of GABAergic neurons, including D-type and RME motor neurons. Furthermore, the oxidative stress evidenced by excessive ROS generation might contribute to the mechanism of mSiNPs damaging neurons. Although the neurotoxicity of mSiNPs was weaker than (nonmesoporous) SiNPs, it is still necessary for researchers to pay attention to the adverse effects caused by mSiNPs in the environmental animals, especially with the rapid increase in mSiNPs application. Considering the conserved property of GABAergic neurons during evolution, these findings will shed light on our understanding of the potential eco-risks of NPs to the nervous system of other animal models.

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The fate and oxidative stress of different sized SiO2 nanoparticles in zebrafish (Danio rerio) larvae

Cited by 55 publications

References 31 publications

Exposure to biogenic phosphorus nano-agromaterials promotes early hatching and causes no acute toxicity in zebrafish embryos

Exposure to biogenic phosphorus nano-agromaterials promotes early hatching and causes no acute toxicity in zebrafish embryos

Enhanced Antioxidant Effects of the Anti-Inflammatory Compound Probucol When Released from Mesoporous Silica Particles

Mesoporous Silica Nanoparticles at Predicted Environmentally Relevant Concentrations Cause Impairments in GABAergic Motor Neurons of Nematode Caenorhabditis elegans

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