The Fate of Corpora Lutea in the Cyclic Golden Hamster

Gaytán, Francisco; Morales, C.; Bellido, C. Bernal; Aguilar, Rafaela; Sánchez-Criado, José E.

doi:10.1006/gcen.2000.7580

Cited by 11 publications

(12 citation statements)

References 32 publications

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“…The novel concept relies on many illustrations (Spanel-Borowski, 2011a) and is here heightened in details. Different fine-tuning of immunoresponses could explain why, in the hamster ovary, CLs completely disappear within one ovarian cycle (Spanel-Borowski and Heiss, 1986;Gaytán et al, 2001b), whereas regressing stages are seen for several cycles in ovaries of rats, cows and human. Luteal cysts and the persistence of a CL, which leads to a prolonged ovarian cycle, might be explained by immunemediated failure.…”

Section: Clinical Perspectives and Concluding Remarksmentioning

confidence: 99%

Five different phenotypes of endothelial cell cultures from the bovine corpus luteum: Present outcome and role of potential dendritic cells in luteolysis

Spanel‐Borowski

2011

Molecular and Cellular Endocrinology

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Section: Clinical Perspectives and Concluding Remarksmentioning

confidence: 99%

Five different phenotypes of endothelial cell cultures from the bovine corpus luteum: Present outcome and role of potential dendritic cells in luteolysis

Spanel‐Borowski

2011

Molecular and Cellular Endocrinology

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“…Though the factors regulating the differentiation of the ovarian interstitial cells of golden hamsters are unknown, previous reports have indicated that TGFβ1 and TGFβ2 [42], steriodogenic enzymes [43,44], epidermal growth factor receptor [45] and estrogen receptors [46] are expressed in the ovarian interstitial cells of golden hamsters. These findings imply that these expression activities correspond to active interstitial cell differentiation [47]. TGFβ can amplify progesterone production and LH receptor induction [48], and TGFβ is essential to maintaining the critical level of LH receptor expression in the rat ovary for induction of ovulation [49].…”

Section: Inhibin and Nerve Growth Factor In Lactating Hamster Ovariesmentioning

confidence: 99%

Expression of Nerve Growth Factor and its Receptors trkA and p75 and Inhibin .ALPHA.-Subunit in the Ovarian Interstitial Cells of Lactating Golden Hamsters

Wang

Shi

Kawaguchi

et al. 2008

Journal of Reproduction and Development

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Abstract. Characteristic daily increases in the plasma levels of luteinizing hormone (LH) are present every afternoon during lactation in golden hamsters. The objective of this study was to investigate the effect of the diurnal rhythm of increases in LH on expression of nerve growth factor (NGF), its receptors trkA and p75 and inhibin α-subunit in the ovarian interstitial cells of lactating golden hamsters. Both lactating and non-lactating groups of postpartum golden hamsters were used in this study. The expression of NGF, its receptors trkA and p75 and inhibin α-subunit were determined by immunohistochemistry. Positive staining of NGF, trkA and p75 was found in the interstitial cells of the lactating group, and no immunoreactivity for NGF, trkA or p75 was observed in the ovarian interstitial cells of the nonlactating group. In addition, immunostaining of inhibin α-subunit was also observed in the interstitial cells of the lactating group but not in those of the non-lactating group. Immunostaining of the inhibin/activin βA-and βB-subunits was observed in the granulosa cells of antral follicles, but not in the interstitial cells of the lactating and non-lactating animals. These results suggest that the diurnal rhythm increases in LH can induce expression of NGF, trkA, p75 and inhibin α-subunit in the ovarian interstitial cells of lactating golden hamsters and that NGF, its receptors trkA and p75 and inhibin α-subunit may have the capacity for autocrine or paracrine modulation of interstitial cell differentiation in golden hamsters. Key words: Golden hamster (Mesocricetus auratus), Inhibin α subunit, Interstitial cell, Nerve growth factor (NGF), p75, trkA (J. Reprod. Dev. 54: [397][398][399][400][401] 2008) he nerve growth factor (NGF), a 26-kDa polypeptide [1], belongs to a family of related proteins required for the survival, maintenance and development of discrete neuronal populations in the central and peripheral nervous systems [2,3]. The effect of NGF has been shown to be mediated through specific membrane receptors high-affinity tyrosine kinase A (trkA), and it is responsible for the biological activities of NGF [4,5]. Furthermore, the effect of NGF is also mediated via low affinity p75 receptor and it is also other neurotropins receptor [6]. It is now well known that NGF and its receptors are expressed in the mammalian ovary. More and more evidence indicates that NGF and its receptors play a critical role in development of the mammalian ovary, oogenesis and folliculogenesis [7][8][9][10][11][12][13].Inhibin/activin subunits are present in numerous mammalian tissues of both endocrine and nonendocrine organs. The dimeric proteins formed from the subunits are members of the transforming growth factor (TGF) β superfamily of growth and differentiation factors and have been isolated and characterized as gonadal peptides. Inhibins and activins are structurally related dimeric gonadal proteins with the ability to regulate follicle stimulating hormone (FSH) secretion from pituitary glands [14]. They are also dim...

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“…However, in 1990s, it was reported that apoptosis occurs in the CL during spontaneous luteal regression in many species [11][12][13][14][15][16]. In the hamster, apoptosis is also observed during luteal regression in the estrous cycle [5,6]. Therefore, in the present study, we revaluated the role of pituitary hormones on the CL, with a particular focus on apoptosis, in the cyclic golden hamster.…”

mentioning

confidence: 92%

“…On the other hand, in the hypophysectomized cyclic hamster, the CL regresses at the same time as in intact cyclic animals [8]. Another study showed that withdrawal of estrogen or androgen and administration of P4 do not affect the luteolytic process in the cyclic hamster [6]. Furthermore, although it is well known that prostaglandin F2α (PGF2α) secreted from the uterus is a strong luteolytic factor in ruminants, hysterectomy does not affect luteal regression in the cyclic rat, mouse and hamster [2].…”

mentioning

confidence: 96%

The Effects of Prolactin and Gonadotropin on Luteal Function and Morphology in the Cyclic Golden Hamster

Kon

Kishi

Arai

et al. 2008

Journal of Reproduction and Development

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Abstract. The present study was conducted to evaluate the endocrinological effects of the pituitary on luteal maintenance and regression in the cyclic golden hamster (Mesocritus auratus). After hypophysectomy (Hypox) at 0900 h on day 1 of the estrous cycle (the day of ovulation), the animals received injection of prolactin (PRL) or PRL plus equine chorionic gonadotropin (eCG). They were decapitated at 1500 h on day 3 of the cycle, and trunk blood was collected for measurement of progesterone (P4). Corpora lutea (CLs) were dissected from one ovary for DNA ladder detection by electrophoresis, determination of DNA fragmentation ratio by fluorometric measurement method and measurement of P4. The other ovary was used for histological observation. After the Hypox, the daily injection of 1 mg ovine PRL restrained the DNA fragmentation ratio and number of apoptotic cell in the CLs. The PRL treatment maintained the luteal morphology and increased the luteal P4 concentration, but not in the plasma P4 concentration. In addition to PRL, injection of 2 IU eCG after the Hypox also restrained the DNA fragmentation ratio and number of apoptotic cells in the CLs to the level of a pregnant animal. The PRL plus eCG treatment maintained the luteal morphology in the same manner as the PRL only treatment and increased not only the luteal but also the plasma P4 concentration. These results suggest that PRL restrains luteal apoptosis and maintains luteal morphology and that the combination of PRL and eCG restrains not only structural but also functional luteal regression in the cyclic hamster. Key words: Apoptosis, Corpus luteum, Golden hamster (Mesocritus auratus), Hypophysectomy, Prolactin (PRL) (J. Reprod. Dev. 54: [418][419][420][421][422][423] 2008) he corpus luteum (CL) is a transient endocrine organ required for normal pregnancy in mammals. The most important function of the CL is to secrete progesterone (P4). If pregnancy does not occur, the CL must regress to allow initiation of a new reproductive cycle. Luteal function and structure are regulated by luteotropic and luteolytic hormones. Luteotropic hormones maintain and activate the CL, and luteolytic hormones lead the CL to regression. Whereas the factors regulating follicle development, ovulation and luteinization are common to many mammalian species, the luteotropic and luteolytic factors are different between species [1-3].The estrous cycle of the golden hamster lasts exactly 4 days (day 1=ovulation day), and the functional life span of the CL is limited to the first 2 days of the cycle. Serum P4 levels decrease drastically at the end of day 2 (functional luteal regression) [4]. Following functional regression, the CL shows signs of structural regression on day 3 of the cycle and vanishes by the next ovulation [5,6]. This rapidity of structural regression is a feature of hamster luteolysis. In the rat, although the functional life span of the CL is about 2 days as in the hamster, the luteal structure persists for 3-4 cycles [1,3]. This difference suggests that the regul...

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The Fate of Corpora Lutea in the Cyclic Golden Hamster

Cited by 11 publications

References 32 publications

Five different phenotypes of endothelial cell cultures from the bovine corpus luteum: Present outcome and role of potential dendritic cells in luteolysis

Five different phenotypes of endothelial cell cultures from the bovine corpus luteum: Present outcome and role of potential dendritic cells in luteolysis

Expression of Nerve Growth Factor and its Receptors trkA and p75 and Inhibin .ALPHA.-Subunit in the Ovarian Interstitial Cells of Lactating Golden Hamsters

The Effects of Prolactin and Gonadotropin on Luteal Function and Morphology in the Cyclic Golden Hamster

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