The Fate of Intracerebral Adrenal Grafts in the Dog

Dixit, Suresh P.

doi:10.1001/archsurg.1969.01340150060011

Cited by 4 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is now realized, however, that the brain is not so privileged. Rejection of foreign solid tissue grafts occurs in the brain just as it does elsewhere (Scheinberg et al, 1967;Lance, 1967a, b;Dixit & Coppola, 1969), although rejection is slower in the brain (Ridley & Cavanagh, 1969b). As with rejection of solid grafts at other sites, cellular rather than humoral mechanisms seem to be responsible, since rejection can be prevented by ALS therapy (Ridley, 1970a, b).…”

Section: Experimental Aspects Ofglioma Rejectionmentioning

confidence: 99%

Clinical significance of immunopathological mechanisms in diseases of the nervous system

Ridley

1971

Clin Experimental Allergy

View full text Add to dashboard Cite

The clinical applications of immunology in neurology are reviewed in relation to autoimmunity, immunosuppression, brain tumour immunity and the transplantation of peripheral nervous tissue. Evidence for considering the role of immunological factors in certain neurological diseases is considered. The clinical value of immunosuppressive therapy in these diseases is discussed. Attention is drawn to immunotherapy as a possible adjunct to present methods of treating gliomas. Finally, possible uses of transplants of peripheral nerve and muscle are mentioned.

show abstract

Section: Experimental Aspects Ofglioma Rejectionmentioning

confidence: 99%

Clinical significance of immunopathological mechanisms in diseases of the nervous system

Ridley

1971

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

Cerebrospinal Fluid Alterations Associated with Central Nervous System Infections

Labadie

1980

Neurobiology of Cerebrospinal Fluid 1

View full text Add to dashboard Cite

Autotransplantation of the adrenal cortex into the spleen of dogs

Matsumoto

1990

The Japanese Journal of Surgery

View full text Add to dashboard Cite

The factors involved in regeneration of the autotrasplanted adrenal cortex were studied experimentally in dogs. On the basis of a number of conditions necessary for the regeneration of adrenocortical tissue, the dogs were divided into 4 groups according to differences in substitution therapy following autotransplantation. The only group to demonstrate long-term survival received an intermittent substitution of cortisone acetate after the completion of 6 days postoperative replacement therapy. The hormonal functions after adrenocortical autotransplantation were examined in the long-term survivers. The secretory function of adrenocortical tissue after autotransplantation was confirmed by the detection of serum concentrations of aldosterone and cortisol, however, estrogens were not detected in the peripheral blood stream following autotransplantation. The negative response to the synthetic ACTH stimulation test observed in this study was evidence of the functional limitation of regenerated cortical tissue. Clinically, however, the procedure performed in this study will be beneficial for patients with advanced and metastatic breast cancer, not only as a form of surgical hormonal therapy, but also as an effective palliative method of treatment.

show abstract

The Fate of Intracerebral Adrenal Grafts in the Dog

Cited by 4 publications

References 7 publications

Clinical significance of immunopathological mechanisms in diseases of the nervous system

Clinical significance of immunopathological mechanisms in diseases of the nervous system

Cerebrospinal Fluid Alterations Associated with Central Nervous System Infections

Autotransplantation of the adrenal cortex into the spleen of dogs

Contact Info

Product

Resources

About