The fate of the ethanol analogue 1,3-butanediol in the dog

Münst, G. J.; Ris-Steiger, M.M.; Galeazzi, Renato L.; Wartburg, J. P. von; Bircher, J

doi:10.1016/0006-2952(81)90210-0

Cited by 11 publications

(2 citation statements)

References 21 publications

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“…Typically, BD is rapidly converted to βHB by hepatic alcohol and aldehyde dehydrogenases (Desrochers et al, 1992). However, these steps are rate limiting and may be influenced by previous ethanol exposure (Münst et al, 1981). In this study, participants habitually consumed low levels of alcohol (∼1.5 standard drinks per week); therefore, their maximal capacity to metabolize BD into βHB could have been below the dose ingested, resulting in the accumulation of BD in the circulation.…”

Section: Discussionmentioning

confidence: 88%

The Effect of 1,3-Butanediol on Cycling Time-Trial Performance

Shaw

Mérien

Braakhuis

et al. 2019

International Journal of Sport Nutrition and Exercise Metabolism

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This study investigated the effect of the racemic β-hydroxybutyrate (βHB) precursor, R,S-1,3-butanediol (BD), on time-trial (TT) performance and tolerability. A repeated-measures, randomized, crossover study was conducted in nine trained male cyclists (age, 26.7 ± 5.2 years; body mass, 69.6 ± 8.4 kg; height, 1.82 ± 0.09 m; body mass index, 21.2 ± 1.5 kg/m2; VO2peak,63.9 ± 2.5 ml·kg−1·min−1; Wmax, 389.3 ± 50.4 W). Participants ingested 0.35 g/kg of BD or placebo 30 min before and 60 min during 85 min of steady-state exercise, which preceded a ∼25- to 35-min TT (i.e., 7 kJ/kg). The ingestion of BD increased blood D-βHB concentration throughout exercise (0.44–0.79 mmol/L) compared with placebo (0.11–0.16 mmol/L; all p < .001), which peaked 1 hr following the TT (1.38 ± 0.35 vs. 0.34 ± 0.24 mmol/L; p < .001). Serum glucose and blood lactate concentrations were not different between trials (all p > .05). BD ingestion increased oxygen consumption and carbon dioxide production after 20 min of steady-state exercise (p = .002 and p = .032, respectively); however, no further effects on cardiorespiratory parameters were observed. Within the BD trial, moderate to severe gastrointestinal symptoms were reported in five participants, and low levels of dizziness, nausea, and euphoria were reported in two participants. However, this had no effect on TT duration (placebo, 28.5 ± 3.6 min; BD, 28.7 ± 3.2 min; p = .62) and average power output (placebo, 290.1 ± 53.7 W; BD, 286.4 ± 45.9 W; p = .50). These results suggest that BD has no benefit for endurance performance.

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Section: Discussionmentioning

confidence: 88%

The Effect of 1,3-Butanediol on Cycling Time-Trial Performance

Shaw

Mérien

Braakhuis

et al. 2019

International Journal of Sport Nutrition and Exercise Metabolism

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“…RS-1,3-Butanediol has been investigated as a carbon source for animal [1][2][3][4][5][6] and human [7,8] nutrition. It has also been proposed as a therapeutic agent for the ethanol withdrawal syndrome [9].…”

Section: Introductionmentioning

confidence: 99%

Metabolism of R- and S-1,3-butanediol in perfused livers from meal-fed and starved rats

Desrochers

David

Garneau

et al. 1992

Biochemical Journal

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The metabolism of millimolar concentrations of R- or S-1,3-butanediol has been studied in perfused livers from fed and starved rats. Protocols were designed to measure in the same experiment (i) uptake of the diol, (ii) the contribution of the diol to ketogenesis, (iii) the contribution of the diol to total fatty acid plus sterol synthesis, and (iv) conversion of S-1,3-butanediol into S-3-hydroxybutyrate. Our data show that R- and S-1,3-butanediol are taken up by the liver at the same rate. Most of the metabolism of R-1,3-butanediol is accounted for by conversion to the physiological ketone bodies R-3-hydroxybutyrate and acetoacetate. Only 29-38% of S-1,3-butanediol uptake is accounted for by conversion into physiological ketone bodies. The balance of S-1,3-butanediol metabolism is conversion to S-3-hydroxybutyrate, lipids and CO2.

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In Vivo Evaluation of Hepatotoxicity by Invasive and Non-Invasive Techniques

Bircher

1982

Archives of Toxicology

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The fate of the ethanol analogue 1,3-butanediol in the dog

Cited by 11 publications

References 21 publications

The Effect of 1,3-Butanediol on Cycling Time-Trial Performance

The Effect of 1,3-Butanediol on Cycling Time-Trial Performance

Metabolism of R- and S-1,3-butanediol in perfused livers from meal-fed and starved rats

In Vivo Evaluation of Hepatotoxicity by Invasive and Non-Invasive Techniques

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