The features of reserpine-induced gastric mucosal lesions

Ma, Xiaoli; L, Gao; Song, Shuwei; Liu, Wei; Wen, Zheng; Zheng, Xiang; Lu, Qingyi; Su, Ding‐Feng

doi:10.1038/aps.2010.74

Cited by 14 publications

(8 citation statements)

References 20 publications

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“…In experimental studies reserpine can be used in single i.p. injections at a dose range of 0.25-6 mg/kg for inducing gastric mucosal lesions in SD rats, (Ma et al 2010) and at 2.5 mg/kg i.p. 16 to 20 hr before experiments for its effect on nociceptive testing.…”

Section: Sas Suppressionmentioning

confidence: 99%

Strategies for therapeutic hypometabothermia

Liu¹,

Chen²

2012

J Exp Stroke Transl Med

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Although therapeutic hypothermia and metabolic suppression have shown robust neuroprotection in experimental brain ischemia, systemic complications have limited their use in treating acute stroke patients. The core temperature and basic metabolic rate are tightly regulated and maintained in a very stable level in mammals. Simply lowering body temperature or metabolic rate is actually a brutal therapy that may cause more systemic as well as regional problems other than providing protection. These problems are commonly seen in hypothermia and barbiturate coma. The main innovative concept of this review is to propose thermogenically optimal and synergistic reduction of core temperature and metabolic rate in therapeutic hypometabothermia using novel and clinically practical approaches. When metabolism and body temperature are reduced in a systematically synergistic manner, the outcome will be maximal protection and safe recovery, which happen in natural process, such as in hibernation, daily torpor and estivation.

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Section: Sas Suppressionmentioning

confidence: 99%

Strategies for therapeutic hypometabothermia

Liu¹,

Chen²

2012

J Exp Stroke Transl Med

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“…Reserpine, first obtained from the root of the Rauvolfia serpentina in 1952, revolutionized the treatment of hypertension. However, long-term overdose use of reserpine causes depression and sexual dysfunction (5). Besides, long-term use of reserpine increases cholinergic tonus; and by suppressing adrenergic activity, it leads to gastric mucosal lesion with an increase in gastric acid production and motility (6).…”

Section: Introductionmentioning

confidence: 99%

“…Some studies indicate that reserpine has strong oxidant activity in plasma and tissues (7)(8)(9). In spite of all these effects, reserpine is still used in China as it is more effective and cheaper along with other hypotensive drugs such as compound hypotensive tablets (CHTs) and compound reserpine tablets (5).…”

Section: Introductionmentioning

confidence: 99%

Effects Of Thymoquinone and Citalopram On Oxidative Stress in Gastric and Duodenum Tissue in Reserpinized Rats

Kuzay¹

2019

Erciyes Med J

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Objective: Medicaments used in the therapy of GIS diseases have many detrimental impacts. Therefore, antioxidant effective molecules can help in the treatment process. This study aimed to examine the oxidant and antioxidant activity of thymoquinone (TQ) and citalopram in gastric and duodenum tissues of reserpinized rats. Materials and Methods: In the study, we split the rats in six groups of six rats each: 1) Control (C) 1; 2) Control (C) 2; 3) reserpine (R); 4) Reserpine+citalopram (R+C); 5) Reserpine+thymoquinone (R+T); 6) Reserpine+citalopram+thymoquinone (R+C+T). Reserpine (0.2 mg/kg) was intraperitoneally administered. TQ (10 mg/kg) and citalopram (10 mg/kg) were intragastrically administered 30 min before reserpine injection. The rats were treated for 14 consecutive days. At the end of the experiment, we examined total antioxidant status and total oxidant status in gastric tissue; and total nitric oxide, malondialdehyde, and glutathione levels in duodenum tissue. Results: There was a reduction on total oxidant status in gastric tissue in the R+C group in comparison with the R group (p<0.01). The decrease in total oxidant status in the R+C+T and R+T groups was more significant (p<0.01). An increase in total antioxidant status was observed in the R+C, R+T, and R+C+T groups when compared to the R group (p<0.01). In comparison to the R group, there was a reduction in malondialdehyde and nitric oxide levels and a rise in glutathione level in duodenum tissue in the R+C+T and R+T groups (p<0.01). Conclusion: Reserpine increased oxidative stress and decreased antioxidant capacity in gastric and duodenum tissues. TQ and citalopram+TQ treatment decreased oxidative stress and increased antioxidant capacity in gastric and duodenum tissues. TQ and citalopram+TQ treatments proved to be more effective in protection from oxidative stress caused by reserpine in gastric and duodenum tissues than citalopram treatment.

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“…Recently it was even reported to be beneficial in the cases of Huntington disease [ 4 ]. Reserpine is generally isolated from the roots of Rauwolfia species [ 5 ], where it is in low content (254.8–689.5 μg/g, dry wt)[ 6 ]. Reserpine shares the similar physicochemical properties of the indole alkaloids in many plants of Rauwolfia species.…”

Section: Introductionmentioning

confidence: 99%

Kinetics and Thermodynamics of Reserpine Adsorption onto Strong Acidic Cationic Exchange Fiber

2015

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The kinetics and thermodynamics of the adsorption process of reserpine adsorbed onto the strong acidic cationic exchange fiber (SACEF) were studied by batch adsorption experiments. The adsorption capacity strongly depended on pH values, and the optimum reserpine adsorption onto the SACEF occurred at pH = 5 of reserpine solution. With the increase of temperature and initial concentration, the adsorption capacity increased. The equilibrium was attained within 20 mins. The adsorption process could be better described by the pseudo-second-order model and the Freundlich isotherm model. The calculated activation energy Ea was 4.35 kJ/mol. And the thermodynamic parameters were: 4.97<ΔH<7.44 kJ/mol, -15.29<ΔG<-11.87 kJ/mol and 41.97<ΔS<47.35 J/mol·K. The thermodynamic parameters demonstrated that the adsorption was an endothermic, spontaneous and feasible process of physisorption within the temperature range between 283 K and 323 K and the initial concentration range between 100 mg/L and 300 mg/L. All the results showed that the SACEF had a good adsorption performance for the adsorption of reserpine from alcoholic solution.

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The features of reserpine-induced gastric mucosal lesions

Cited by 14 publications

References 20 publications

Strategies for therapeutic hypometabothermia

Strategies for therapeutic hypometabothermia

Effects Of Thymoquinone and Citalopram On Oxidative Stress in Gastric and Duodenum Tissue in Reserpinized Rats

Kinetics and Thermodynamics of Reserpine Adsorption onto Strong Acidic Cationic Exchange Fiber

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