The Feeling of Healing

Henderson, James L.; Ferguson, Mark W. J.; Terenghi, Giorgio

doi:10.1097/prs.0b013e3182365fda

Cited by 6 publications

(6 citation statements)

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“…Furthermore, during healing wounds are initially hyperinnervated, including itch‐conducting sensory nerves. The nerve density normalizes during scar maturation – it has been observed that tissues fail to heal when there is no nerve supply …”

Section: Discussionmentioning

confidence: 99%

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Burden of itch in epidermolysis bullosa

et al. 2014

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Section: Discussionmentioning

confidence: 99%

“…The nerve density normalizes during scar maturation it has been observed that tissues fail to heal when there is no nerve supply. 7 However, it cannot be excluded that in the different forms of EB, the underlying defect triggers specific reaction 0Á68** 0Á32 0Á87** 100 Consequences (5) 0Á52** 0Á41* 0Á68** 0Á66** 100…”

Section: Discussionmentioning

confidence: 99%

Burden of itch in epidermolysis bullosa

et al. 2014

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“…56 These, and products of the inflammatory cascades that they initiate, might not only mediate the recruitment of immune cells to the wounded site (Figure 2; box B2), but also directly activate sensory neurons, triggering itch signals or even increasing the neurons' responsiveness to pruritogens (Figure 2; box E). 21 In turn, sensory fibres in the skin release neuromediators, including substance P, calcitonin gene-related peptide, brain-derived natriuretic peptide and nerve growth factor, 20,57,58 all of which are implicated in pruritus pathophysiology (Figure 2; box F). 18 The concept that the wound healing process triggers pruritus is supported by observations that this is a major problem in patients with burns.…”

Section: Inflammation and Epidermolysis Bullosa Skinmentioning

confidence: 99%

Prevalence, pathophysiology and management of itch in epidermolysis bullosa*

et al. 2020

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Epidermolysis bullosa (EB) is a highly diverse group of inherited skin disorders, resulting from mutations in genes encoding proteins of the dermoepidermal junction. Itch (pruritus) is one of the most common symptoms across all EB subtypes. It occurs in blistered or wounded sites, or manifests as a generalized phenomenon, thereby affecting both intact skin and healing wounds. The mechanism of pruritus in EB is unclear. It is likely that skin inflammation secondary to barrier disruption, wound healing cascades and dysregulated activation of epidermal sensory nerve endings are all involved in its pathophysiology on the molecular and cellular level. Understanding these mechanisms in depth is crucial in developing optimized treatments for people with EB and improving quality of life. This review summarizes current evidence on the prevalence, mechanisms and management of itch in EB.There is growing evidence that itch is the result of a dysregulated interplay between keratinocytes, immune cells and

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“…For instance, products containing growth factors or cytokines can be applied for accelerating healing and reducing wound scarring as they stimulate the proliferation of many types of skin cells and thus enhance epidermal renewal. 60,64 Centella asiatica extract is a traditional ingredient with well-documented wound-healing properties, as well as multiple other healthcare benefits. The effectiveness of this extract for skin repair has been demonstrated in animal models of wound healing, with the effects most likely being due to the presence of the constituent bioactives, madecassoside and asiaticoside.…”

Section: Healing Treatmentsmentioning

confidence: 99%

Combined multilevelanti‐agingstrategies and practical applications of dermocosmetics in aesthetic procedures

Park,

López Gehrke

2024

Acad Dermatol Venereol

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Management of the signs of facial aging and other cosmetic skin problems have greatly evolved in the past years. People are also seeking to improve their well‐being and global skin appearance, and when they consider using cosmetic procedures, they expect natural and long‐lasting aesthetic results. Combined dermocosmetic approaches that address the signs of facial aging at all levels are increasingly being used by dermatologists to meet patient expectations while ensuring their safety. Minimally invasive and reversible procedures that can be performed in only one session are popular approaches for skin restructuring and volumizing as they are flexible, rapid and less burdensome for patients. These interventions can achieve even better outcomes when they are combined with cosmeceuticals as pre‐ or post‐procedural adjuvants to prepare the skin, accelerate recovery and sustain results. The use of topical dermocosmetics is also recommended as part of the daily skin care routine to improve skin quality and help maintain skin barrier function. This review thus outlines the most commonly used combined multilevel anti‐aging strategies, which start by addressing the deepest skin layers and then the more superficial signs of skin aging. Examples of multi‐active cosmeceuticals and skin delivery enhancing systems are also presented, together with examples of the use of dermocosmetics as supportive care for aesthetic procedures, to provide insights into current applications of dermocosmetic products.

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The Feeling of Healing

Cited by 6 publications

References 1 publication

Burden of itch in epidermolysis bullosa

Burden of itch in epidermolysis bullosa

Prevalence, pathophysiology and management of itch in epidermolysis bullosa*

Combined multilevelanti‐agingstrategies and practical applications of dermocosmetics in aesthetic procedures

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