The Fer tyrosine kinase acts as a downstream interleukin-6 effector of androgen receptor activation in prostate cancer

Rocha, Joice; Zouanat, Fatima Z.; Zoubeidi, Amina; Hamel, Lucie; Benidir, Tarik; Scarlata, Eleonora; Brimo, Fadi; Aprikian, Armen; Chevalier, Simone

doi:10.1016/j.mce.2013.07.017

Cited by 26 publications

(18 citation statements)

References 34 publications

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“…Fer is involved in many processes including cell proliferation [27,28], cell adhesion [29], cell migration [30], and even oocyte maturation [31]. Fer is also implicated in several cancers [32-34]. Interestingly, a testis-specific alternatively-spliced isoform of Fer, FerT, has a distinct, shorter N-terminus than the full-length Fer protein and participates in acrosome formation through phosphorylation of actin remodeling proteins [35].…”

Section: Discussionmentioning

confidence: 99%

SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans

et al. 2014

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BackgroundThe SPE-8 group gene products transduce the signal for spermatid activation initiated by extracellular zinc in C. elegans. Mutations in the spe-8 group genes result in hermaphrodite-derived spermatids that cannot activate to crawling spermatozoa, although spermatids from mutant males activate through a pathway induced by extracellular TRY-5 protease present in male seminal fluid.ResultsHere, we identify SPE-8 as a member of a large family of sperm-expressed non-receptor-like protein-tyrosine kinases. A rescuing SPE-8::GFP translational fusion reporter localizes to the plasma membrane in all spermatogenic cells from the primary spermatocyte stage through spermatids. Once spermatids become activated to spermatozoa, the reporter moves from the plasma membrane to the cytoplasm. Mutations in the spe-8 group genes spe-12, spe-19, and spe-27 disrupt localization of the reporter to the plasma membrane, while localization appears near normal in a spe-29 mutant background.ConclusionsThese results suggest that the SPE-8 group proteins form a functional complex localized at the plasma membrane, and that SPE-8 is correctly positioned only when all members of the SPE-8 group are present, with the possible exception of SPE-29. Further, SPE-8 is released from the membrane when the activation signal is transduced into the spermatid.

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Section: Discussionmentioning

confidence: 99%

SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans

et al. 2014

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“…75 Several studies showed that FER activates androgen receptor by phosphorylating Tyr223 in androgen recetpor 76 and is essential for NF-kB activation of epidermal growth factor receptor. 77 Some studies indicate that FER is an essential component of stem cell tyrosine kinase 1 77 and mast cell growth factor receptor (kit) 78 signaling.…”

Section: Fusions In Prostate Cancermentioning

confidence: 99%

Discovery and Classification of Fusion Transcripts in Prostate Cancer and Normal Prostate Tissue

Luo

Liu

Zuo

et al. 2015

The American Journal of Pathology

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Fusion transcript formation is one of the fundamental mechanisms that drives the development of prostate cancer. Because of the advance of high-throughput parallel sequencing, many fusion transcripts have been discovered. However, the discovery rate of fusion transcripts specific for prostate cancer is lagging behind the discoveries made on chromosome abnormalities of prostate cancer. Recent analyses suggest that many fusion transcripts are present in both benign and cancerous tissues. Some of these fusion transcripts likely represent important components of normal gene expression in cells. It is necessary to identify the criteria and features of fusion transcripts that are specific for cancer. In this review, we discuss optimization of RNA sequencing depth for fusion transcript discovery and the characteristics of fusion transcripts in normal prostate tissues and prostate cancer. We also propose a new classification of cancer-specific fusion transcripts on the basis of their tail gene fusion protein product and the roles that these fusions may play in cancer development. (Am J Pathol 2015, 185: 1834e1845; http://dx

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“…It has been described in normal tissues to be a downstream integrator of membrane and cytosolic signaling pathways(13–15) boasting a beneficial participation in cell survival, cytoskeleton re-arrangement, epithelial maintenance and leukocyte differentiation and chemotaxis. However in several cancer models, FER has been implied to be involved in mechanisms of malignant cell transformation, tumoral invasion and metastatic potential(16–19). FER overexpression is a negative predictor of survival in Non-Small Cell Lung Cancer (NSCLC)(20).…”

Section: Introductionmentioning

confidence: 99%

Electroporation-mediated delivery of the FER gene in the resolution of trauma-related fatal pneumonia

et al. 2016

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Injured patients with lung contusion (LC) are at risk of developing bacterial pneumonia (PNA) followed by sepsis and death. A recent Genome-wide Association Study, showed FER gene expression positively correlating with survival rates among individuals with above conditions. We sought to determine if electroporation-mediated (EP) delivery of FER gene could indeed improve survival, in a lethal model of combined LC and PNA. C57BL/6 mice sustained unilateral LC, which preceded a 500 Klebsiella CFU inoculation by 6 hrs. In-between these insults, human FER plasmid (pFER) was introduced into the lungs followed by eight EP pulses applied externally (10ms at 200V/cm). Control groups included EP of empty vector (pcDNA3) or Na+/K+-ATPase genes (pPump) and no treatment (LC + PNA). We recorded survival, histology, lung mechanics, bronchial alveolar fluid (BAL), FER and inflammatory gene expression and bacteriology. The data shows that 7-day survival was significantly improved by pFER compared to control groups. pFER increased BAL monocytes and activated antibacterial response genes (NOS, Fizz). pFER treatment showed decreased lung and blood Klebsiella counts reaching, in some cases, complete sterilization. In conclusion, FER gene delivery promoted survival in LC+PNA mice via recruitment of activated immune cells, improving efficiency of bacterial clearance within contused lung

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The Fer tyrosine kinase acts as a downstream interleukin-6 effector of androgen receptor activation in prostate cancer

Cited by 26 publications

References 34 publications

SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans

SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans

Discovery and Classification of Fusion Transcripts in Prostate Cancer and Normal Prostate Tissue

Electroporation-mediated delivery of the FER gene in the resolution of trauma-related fatal pneumonia

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