The Ferrocifen Family as Potent and Selective Antitumor Compounds: Mechanisms of Action

Synthesis of Nanoporous Carbon–Cobalt‐Oxide Hybrid Electrocatalysts by Thermal Conversion of Metal–Organic Frameworks

“…This strong cytotoxic effect has been ascribed to the generation of quinone methides (QMs) obtained through oxidation of the ferrocene moiety followed by that of the phenol ring, involving a ferrocene–double bond–phenol moiety 15–17. As iron, ruthenium, and osmium are the three members of group 8, it seemed logical to synthesize osmocene analogues 3a – 3c of the ferrocifens to compare their cytotoxicities with those of the ruthenocifens 2a – 2c and the ferrocifens 1a – 1c .…”

Osmocenyl-tamoxifen derivatives target the thioredoxin system leading to a redox imbalance in Jurkat cells

“…Amongst the promising derivatives of ferrocene, the ferrocifen series, derived initially from tamoxifen, the drug used to combat hormone-dependent breast cancers, has been the subject of a number of studies [20][21][22]. These organometallic species can operate on cancerous cells via the signaling pathways of senescence [23,24] or apoptosis, with markedly different effects depending on the concentration at which they are used and the type of cell involved, while healthy cells are affected only slightly or not at all [25].…”

Selective cytotoxicity of arene tricarbonylchromium towards tumour cell lines

“…Organometallic compounds have been extensively studied for their applications in medicine over the last two decades [13][14][15][16][17][18]. The first fruit was arsphenamine (Salvarsan), which is based on arsenic (despite its unfavourable reputation as poison) and azobenzene, serving for the treatment of syphilis and trypanosomiasis.…”