The Fibroblast Growth Factor Receptor-4 Arg388 Allele is Associated with Gastric Cancer Progression

Ye, Yanwei; Shi, Yingqiang; Zhou, Ye; Du, Chunyan; Wang, Chunmeng; Zhan, Heqin; Zheng, Biqiang; Cao, Xi; Sun, Meng; Fu, Hong

doi:10.1245/s10434-010-1323-6

Cited by 27 publications

(23 citation statements)

References 21 publications

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“…In the human FGFR4 gene, a single-nucleotide polymorphism (SNP) from G to A at codon 388 at exon 9 changes the amino acid sequence of FGFR4 from glycine to arginine (Gly388 to Arg388). FGFR4 Gly388Arg was found to be associated with poor outcomes in breast (32), ovarian (33), lung (34) and gastric cancer (18). FGFR4 amplification was also found in pancreatic (35), renal cell (36) and gastric cancer (19).…”

Section: Discussionmentioning

confidence: 99%

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Prognostic significance of the co-overexpression of fibroblast growth factor receptors 1, 2 and 4 in gastric cancer

Murase

Inokuchi

Takagi

et al. 2014

Molecular and Clinical Oncology

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Abstract. The overexpression of fibroblast growth factor receptor (FGFR) 2 is an established prognostic factor and treatment target in gastric cancer. However, the roles of other FGFRs have not been fully elucidated. In this study, we investigated the correlations of the expression of FGFR1-4 with clinicopathological characteristics and outcomes in gastric cancer. Tumor samples were obtained from 222 patients with gastric adenocarcinoma who underwent gastrectomy between 2003 and 2007. The expression of each FGFR was measured in the tumors by immunohistochemical analysis. The overexpression of FGFR1, FGFR2 or FGFR4 was found to be significantly associated with tumor progression, including depth of invasion, lymph node metastasis, pathological stage and distant metastasis or recurrent disease. Patients exhibiting overexpression of FGFR1, FGFR2 or FGFR4 had a significantly poorer disease-specific survival (DSS; P<0.001, P=0.008 and P<0.001, respectively). Moreover, the co-overexpression of all three FGFRs was significantly associated with a poorer DSS compared to the expression of none or only one of the FGFRs (P<0.001 and P=0.001, respectively) and it was found to be an independent prognostic factor (HR=1.71, 95% CI: 1.02-2.85, P=0.041). In conclusion, high expression of FGFR1, FGFR2 or FGFR4 was associated with tumor progression and poor survival in patients with gastric cancer. Similar to FGFR2, FGFR1 and FGFR4 may be considered as prognostic factors and treatment targets in gastric cancer.

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Section: Discussionmentioning

confidence: 99%

“…Overexpression of these FGFRs in gastric cancer was reported by a few small studies (16)(17)(18)(19). In this study, we aimed to investigate the correlations of FGFR1-4 immunohistochemical expression with clinicopathological characteristics and outcomes in gastric cancer.…”

Section: Introductionmentioning

confidence: 97%

Prognostic significance of the co-overexpression of fibroblast growth factor receptors 1, 2 and 4 in gastric cancer

Murase

Inokuchi

Takagi

et al. 2014

Molecular and Clinical Oncology

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“…It was found a significant association between Gly388Arg and gastric cancer patient survival, suggesting that FGFR4 Arg388 genotype might be a marker of gastric cancer progression (Ye et al, 2010;Ye et al, 2011). Oncogenesis FGFR4 expression was associated to lymph node status and survival decreased with an increased in FGFR4 FGFR4 (fibroblast growth factor receptor 4) Peláez-García A, et al Atlas Genet Cytogenet Oncol Haematol.…”

Section: Diseasementioning

confidence: 99%

FGFR4 (fibroblast growth factor receptor 4)

Peláez‐García¹,

Barderas²,

Casal³

2012

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IdentityOther names: CD334, JTK2, TKF HGNC (Hugo): DNA/RNA DescriptionThe DNA was cloned in 1991 (Partanen et al., 1991). 18.9 kb; 18 exons. Transcription3.1 kb mRNA; alternative splicing gives rise to 18 transcripts with evidence of 11 transcripts at protein level.FGFR4 comprises an extracellular domain, a transmembrane domain, and an intracellular domain. FGFR4 alternative splicing has been described, with up to 18 different transcripts ranging from 552 to 3559 bp, (evidence of 11 transcripts at protein level ranging from 87 to 1030 aminoacids).

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“…Как и при других опухолях, прогностически значи-мым также оказалось наличие полиморфизма гена FGFR4 -Gly388Arg, приводящее к замене в молекуле FGFR4 аминокислоты глицина на аргинин в 388 положении [91].…”

Section: рак желудкаunclassified

Fibroblast growth factor receptors in malignant tumors

Федянин¹,

Khmelkova²,

Серебрийская³

et al. 2015

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The Fibroblast Growth Factor Receptor-4 Arg388 Allele is Associated with Gastric Cancer Progression

Abstract: Based on this study, FGFR4 Arg388 genotype-a marker for gastric cancer progression-may predict prognosis of gastric cancer.

Cited by 27 publications

References 21 publications

Prognostic significance of the co-overexpression of fibroblast growth factor receptors 1, 2 and 4 in gastric cancer

Prognostic significance of the co-overexpression of fibroblast growth factor receptors 1, 2 and 4 in gastric cancer

FGFR4 (fibroblast growth factor receptor 4)

Fibroblast growth factor receptors in malignant tumors

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