The fine structure of atypical ciliated cells in the human gastric epithelium

Kawamata, Seiichi; Kubota, Yoshiki; Sawataishi, Masaru; Takaya, Kenichi

doi:10.1007/bf02899045

Cited by 12 publications

(8 citation statements)

References 22 publications

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“…Assuming that specific stem cells do remain in these different epithelia, one could speculate that under appropriate stimulus or physiological conditions, ciliated cells could differentiate within the gastric mucosa and gastric mucous cells could develop within the adult esophageal epithelium. Therefore, the present observations could support an embryological basis for the presence of these heterotopical cell types found in adult tissues (Rector and Connerly, 1941;Jabbari et al, 1985;Kawamata et al, 1986).…”

Section: Esophagogastric Junctionsupporting

confidence: 75%

“…The occurrence of ciliated epithelium in the human embryonic esophagus was reported at the turn of the century (Johnson, 1910) with developmental changes being described several years later (Johns, 1952). It is interesting to note that patches of ciliated epithelium may still be present at birth (Rector and Connerly, 1941) and that atypical ciliated cells have been reported to be present in human gastric epithelium (Kawamata et al, 1986). On the other hand, heterotopic gastric mucosa in the esophagus has been observed in children (Rector and Conerly, 1941) and adults (Jabbari et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

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Morphological studies of the developing human esophageal epithelium

Ménard

1995

Microscopy Res & Technique

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This article focusses on the structural development of human esophageal ciliated epithelium. A combination of transmission electron microscopic (TEM), scanning electron microscopic (SEM), radioautographic, and light microscopic (LM) analyses were carried out using intact fetal tissues between 8 and 20 weeks of gestation as well as cultured esophageal explants. Up to the age of 10 weeks, the stratified esophageal epithelium consisted of two longitudinal primary folds. The surface cells were undifferentiated and contained large glycogen aggregates. Between 11 and 16 weeks, the primary folds (now up to four) had developed secondary folds. The thickness of the epithelium drastically increased (123%) in concomittance with a differentiation of surface columnar ciliated cells. These highly specialized surface cells exhibited junctional complexes and well-developed organelles with numerous microvilli interspersed among the cilia. Transverse sections revealed the internal structure of the cilia with a consistent pattern of nine doublet microtubules surrounding a central pair of single microtubules. Freeze-fracture studies illustrated the presence of a ciliary necklace composed of 6 ring-like rows of intramembranous particles. They also revealed the structure of ciliary cell tight junctions consisting of up to nine anastomosing strands (P-face) or complementary grooves (E-face). Ultrastructural studies (LM, TEM, SEM) of the esophageal squamous epithelium obtained after 15 days of culture showed that the newly formed epithelium was similar to adult human epithelium. Finally LM and SEM observations established that the esophagogastric junction was not yet well delineated, consisting of a transitional area composed of a mixture of esophageal ciliated cells and gastric columnar mucous cells.

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Section: Esophagogastric Junctionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Morphological studies of the developing human esophageal epithelium

Ménard

1995

Microscopy Res & Technique

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“…Furthermore, ciliogenesis with 9+0 and 8+1 patterns has been observed in epithelia at sites distant from the main lesions, such as gastric sites (Kawamata et al 1986;Rubio et al 1990) and ovarian adenocarcinoma (Gupta et al 1985). The authors mentioned above have however neither correlated the data with an imbalance in steroids levels nor ascertained the function of this cell type; they have only shown the existence of the ciliogenesis phenomenon.…”

Section: Discussionmentioning

confidence: 88%

Experimental endocrine therapies promote epithelial cytodifferentiation and ciliogenesis in the gerbil female prostate

et al. 2007

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The incidence of ciliated cells in the prostate gland of the female gerbil (Meriones unguiculatus) is uncommon and apparently becomes more frequent during androgen (testosterone cypionate) and anti-estrogen (letrozole) endocrine therapies. To evaluate the effects of such drug therapies on the induction of ciliogenesis in the glandular epithelium of female prostate glands, adult female gerbils aged 90 days were treated for 14 days with testosterone and letrozole after which their prostate glands were removed for histological, ultrastructural, and serological analyses. The cytodifferentiation of the ciliated phenotype in the alveolar epithelium became more frequent after both the testosterone and the letrozole treatments. The ciliogenesis phenomenon of the epithelial cells in the prostate gland of female gerbils thus appears to be induced by variations in the increase of androgen levels.

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“…Occasionally, double cilia are found in adenohypophyseal cells (BARNES, 1961;DAHL, 1967;WHEATLEY, 1967b) as well as in pancreatic islet cells as shown in the present study. Multiple cilia, except for typical kinocilia, were reported only under pathological conditions: BoQUIST (1968) described the appearance of multiple cilia (both 9+0 and 9+2 in axoneme pattern) in the pancreatic ductular epithelium after alloxan-treatment, and KAWAMATA et al (1986) found multiple cilia (9+0 pattern) in some gastric epithelial cells in gastric ulcer and cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Electron microscopic observation of the primary cilium in the pancreatic islets.

Yamamoto

Kataoka

1986

Arch. Histol. Jap., Arch. Histol. Jpn

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Summary.A primary cilium often projected from the Golgi region of pancreatic A, B and D cells.The proximal portion of the cilium was found surrounded by a tubular invagination of the plasmalemma, and then the cilium extended into the intercellular canaliculus. The most proximal portion of the ciliary membrane exhibited periodical densities which might correspond to the ciliary necklace.The axoneme of the cilium was basically of the 9+0 pattern, i.e., nine peripheral doublets and no central singlet, though it was modified along the length of the cilium.Although a few appendages were projected from each doublet, it was difficult to identify dynein arms and nexin links.At the most proximal portion of the cilium, a "champagne-glass" structure connected each doublet with the ciliary membrane.The distal and proximal centrioles of the diplosome were connected to each other by a striated band.The proximal centriole, which served as a basal body, had accessory structures, such as alar sheets, basal feet and rootlets.Frequent projections of the primary cilium and its elaborate structure suggest that the cilium is not an aberrant structure but rather one which plays a certain role in the islet cell function.

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The fine structure of atypical ciliated cells in the human gastric epithelium

Cited by 12 publications

References 22 publications

Morphological studies of the developing human esophageal epithelium

Morphological studies of the developing human esophageal epithelium

Experimental endocrine therapies promote epithelial cytodifferentiation and ciliogenesis in the gerbil female prostate

Electron microscopic observation of the primary cilium in the pancreatic islets.

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