The fine structure of human thyroid cancer

Johannessen, Jan Vincents; Gould, Victor E.; Jao, Wellington

doi:10.1016/s0046-8177(78)80025-2

Cited by 98 publications

(22 citation statements)

References 30 publications

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“…It has been reported that ICL are frequently encountered in anaplastic carcinomas of the thyroid and thus indicate a follicular cell origin. 6,12 In the present case, the tumor cells did not react to thyroglobulin. Multiple cytoplasmic vacuoles are sometimes seen in cystic papillary carcinoma of the thyroid, and their presence has been shown to be useful in diagnosing papillary carcinoma.…”

Section: Discussioncontrasting

confidence: 43%

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Intracytoplasmic Lumina in Medullary Carcinoma of the Thyroid Gland

Kinjo¹,

Yohena²,

Kunishima³

2003

Acta Cytologica

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Section: Discussioncontrasting

confidence: 43%

“…[8][9][10][11] However, there are only a few descriptions of ICL, not only in MCT but also in other thyroid tumors. [4][5][6]12 Lowhagen and Linsk 4 mentioned intracytoplasmic vacuoles, suggesting mucous production with MCT. They also reported that these vacuoles could not be stained for calcitonin.…”

Section: Discussionmentioning

confidence: 99%

Intracytoplasmic Lumina in Medullary Carcinoma of the Thyroid Gland

Kinjo¹,

Yohena²,

Kunishima³

2003

Acta Cytologica

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“…To our knowledge, ultrastructural studies of cutaneous métastasés from follicular thyroid carcinomas have not been done as yet. Histologically, the differential diagnosis between benign adenomas and well-differentiated carci nomas of the follicular type may be difficult [2,13]. Cellu lar pleomorphism of follicular carcinoma is rare [1].…”

Section: Discussionmentioning

confidence: 99%

“…For determination of malignancy investigation of the tumor on ultrastructural level maybe helpful. Johannessenet al [ 13] stated that the importance of ultrastructural investi gations in separating follicular adenomas from carcino mas has not been proven. In contrast, Valcnta and Michel-Béchet [12] reported ultrastructural changes which are considered to be significant for malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…Hematogeneous métastasés are much more frequent than in papillary carcinomas [1], Common sites of métastasés of follicular thyroid carcinoma are the lung, the skeleton and the brain [2]. However, the occur rence of cutaneous métastases of thyroid carcinomas has rarely been reported [3][4][5][6][7][8][9], Immunohistologically, thy roid carcinomas and their métastasés can be identified byantibodies against thyroglobulin [ 10,11], The ultrastruc ture of follicular thyroid carcinomas is well described in the primary lesions [12][13][14], Cutaneous métastases, toour knowledge, have not yet been investigated on the ultrastructural level.…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous Metastases from Follicular Thyroid Carcinoma: Histology, Immunohistology, and Electron Microscopy

1991

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Cutaneous metastases from thyroid carcinoma are extremely rare. We report 2 cases of skin metastases from a follicular thyroid carcinoma. A 53-year-old female patient underwent subtotal thyroidectomy because of the clinical suspicion of malignancy. Histological examination of the resected tissue did not clearly prove malignant features. Eight years later a cutaneous metastasis erupted next to the operation site at the neck. A 66-year-old female patient noticed a growing solitary skin nodule in the occipitoparietal region of her scalp 2 years before a follicular thyroid carcinoma was detected.

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Papillary Adenocarcinoma of Minor Salivary Gland Origin in a Child

Crocker¹,

Kreutner²,

Othersen³

et al. 1983

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\A papillary adenocarcinoma with metastasis occurred in a 5-year-old child. The neoplasm arose on the anterolateral sublingual aspect of the tongue and metastasized to a submandibular lymph node. Histologically, the tumor contained broad glandular papillary projections. The tumor cells were cuboidal and had vesicular, "ground glass" nuclei. Colloidlike material was found within the stroma and lumen of the glands. To determine whether the papillary adenocarcinoma was of minor salivary gland or ectopic thyroid in origin, ultrastructural, histochemical, and immunohistochemical techniques were applied to make this clinically important distinction. Ultrastructural and immunohistochemical studies did not indicate the site of origin. Histochemical methods, however, demonstrated the colloidlike material to be sulfated mucopolysaccharide, which was nonreducible by ferric ferrocyanide. These histochemical properties and the anterolateral location identified the tumor as salivary gland in origin.Tumors of minor salivary glands and mucous membranes of the oral cavity and upper respiratory tract have a diversity of histopathologic appearances and a variety of clinical courses. The vast majority of these tumors occurs in older adults.The present case of papillary adeno¬ carcinoma is a rare variety of carcinoma of the minor salivary gland, and its occurrence in a child of 5 years is unique. Because of its rarity, histolog¬ ie features, and location on the tongue, it presented a problem in dif¬ ferentiating between a salivary gland tumor and the more common papil¬ lary carcinoma of ectopie thyroid gland. The diagnostic criteria for Fig 1.-Sublingual tumor was composed of broad papillary projections with sparsely cellular collagenous stroma. Papillary projections formed almost solid tumor mass (hematoxylin-eosin, original magnification X40).

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The fine structure of human thyroid cancer

Cited by 98 publications

References 30 publications

Intracytoplasmic Lumina in Medullary Carcinoma of the Thyroid Gland

Intracytoplasmic Lumina in Medullary Carcinoma of the Thyroid Gland

Cutaneous Metastases from Follicular Thyroid Carcinoma: Histology, Immunohistology, and Electron Microscopy

Papillary Adenocarcinoma of Minor Salivary Gland Origin in a Child

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