The First Case of Chronic Otitis Media due to <i>Kerstersia gyiorum</i> in Korea

Kim, Jin Hong; Lee, Eun-Young; Lee, Yangsoon

doi:10.3343/alm.2018.38.6.607

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…2,21,32 The following are also risk factors: advanced age; invasive or traumatic operations, such as the use of a ventilator, or surgery; diseases such as hypertension, diabetes, and cancer; and treatment with glucocorticoids, immunosuppressants, or broad-spectrum antibiotics. 22,25,28 In this study, the source of the samples differed in each patient; therefore, the relationship between K. gyiorum and the isolation site deserves further study.…”

Section: Discussionmentioning

confidence: 90%

“…Among the previously reported cases with mixed infections, multiple species were identified, including Enterobacteriaceae , non-fermenting Gram-negative bacilli , Staphylococcus aureus, and diphtheroids. 13 , 20 , 24 , 25 Therefore, as an opportunistic pathogen, K. gyiorum may easily develop in concomitant infections. The patient in Case 1 had a mixed bacterial infection.…”

Section: Discussionmentioning

confidence: 99%

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Kerstersia gyiorum isolated for the first time from two patients with neurodegenerative disease: report of two unusual cases and a review of the literature

et al. 2023

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With the development of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and 16S ribosomal RNA (rRNA) gene sequencing, increasing numbers of new microorganisms are being discovered. In this report, Kerstersia gyiorum was isolated for the first time from the sputum of two elderly patients with neurodegenerative disease, and integrated traditional Chinese and Western medicine was used for treatment. The bacteria’s growth characteristics, biochemical reaction characteristics, sensitivity to antibiotics, and the patients’ treatment are described, with a review of previous reports.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Kerstersia gyiorum isolated for the first time from two patients with neurodegenerative disease: report of two unusual cases and a review of the literature

et al. 2023

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“…While otitis media is commonly seen in clinical practice, it is exceedingly rare to identify Kerstersia Gyiorum as the causative infectious organism. There have only been 6 reports of chronic otitis media due to this microorganism, with a total of 9 cases described worldwide [5][6][7][8][9][10]. Each of the cases identified Kerstersia Gyiorum as the cause of chronic otitis media, with seven of the nine cases describing Chronic Suppurative Otitis Media (CSOM) and one case describing cholesteatomas chronic otitis media.…”

Section: Discussionmentioning

confidence: 99%

“…Other microbes have been implicated in the development of chronic otitis media, though, and infections with uncommon organisms have been described. Kerstersia Gyiorum has recently been recognized as a rare but possible cause of chronic otitis media, with only a few cases having been reported worldwide [5]. While infection with Kerstersia Gyiorum is infrequent, it is important to recognize this microbe as a possible cause of COM that is resistant to conventional treatment.…”

Section: Introductionmentioning

confidence: 99%

Refractory chronic otitis media and mixed hearing loss due to infection with levaquin-resistant KERSTERSIA GYIORUM: A case report and review of the literature

Holmes¹,

Busby²,

Noonan³

et al. 2021

J Clin Images Med Case Rep

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A 39-year-old Caucasian male, with a past medical history of purulent drainage of both ears as an infant and multiple tympanostomy tube placements in childhood, presented our ENT clinic complaining of right ear fluid drainage and hearing loss for the past year. Two months prior to presentation, he began to have increased fluid drainage from the right ear. Examination of the right external auditory canal showed thick, white fluid and a tympanic membrane perforation with a protruding small mass. A sample of the fluid was obtained. Culture of the right EAC fluid grew aerobic, gram-negative rods, identified as Kerstersia Gyiorum. The patient was initially treated with topical ofloxacin and topical prednisolone drops. He was seen again 4 weeks later and was noted to have persistent fluid drainage from the right ear. At this time, oral sulfamethoxazole-trimethoprim was added to his regimen Keywords: Chronic otitis media; hearing loss; treatment resistant otitis media; uncommon infectious microorganism; Kerstersia Gyiorum

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“…Since then, there have been one case of infection with a second species of Kerstersia , Kerstersia similis [4] and 12 publications describing 14 cases of patients with various diseases infected with K . gyiorum [2, 3, 5–13]. Among them, seven cases were associated with chronic otitis media [2, 5, 6, 8, 11, 13], three with chronic leg wound [2, 7, 10].…”

Section: Introductionmentioning

confidence: 99%

Genomic characterization of Kerstersia gyiorum SWMUKG01, an isolate from a patient with respiratory infection in China

et al. 2019

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Background The Gram-negative bacterium Kerstersia gyiorum , a potential etiological agent of clinical infections, was isolated from several human patients presenting clinical symptoms. Its significance as a possible pathogen has been previously overlooked as no disease has thus far been definitively associated with this bacterium. To better understand how the organism contributes to the infectious disease, we determined the complete genomic sequence of K . gyiorum SWMUKG01, the first clinical isolate from southwest China. Results The genomic data obtained displayed a single circular chromosome of 3, 945, 801 base pairs in length, which contains 3, 441 protein-coding genes, 55 tRNA genes and 9 rRNA genes. Analysis on the full spectrum of protein coding genes for cellular structures, two-component regulatory systems and iron uptake pathways that may be important for the success of the bacterial survival, colonization and establishment in the host conferred new insights into the virulence characteristics of K . gyiorum . Phylogenomic comparisons with Alcaligenaceae species indicated that K . gyiorum SWMUKG01 had a close evolutionary relationships with Alcaligenes aquatilis and Alcaligenes faecalis . Conclusions The comprehensive analysis presented in this work determinates for the first time a complete genome sequence of K . gyiorum , which is expected to provide useful information for subsequent studies on pathogenesis of this species.

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The First Case of Chronic Otitis Media due to Kerstersia gyiorum in Korea

Cited by 5 publications

References 8 publications

Kerstersia gyiorum isolated for the first time from two patients with neurodegenerative disease: report of two unusual cases and a review of the literature

Kerstersia gyiorum isolated for the first time from two patients with neurodegenerative disease: report of two unusual cases and a review of the literature

Refractory chronic otitis media and mixed hearing loss due to infection with levaquin-resistant KERSTERSIA GYIORUM: A case report and review of the literature

Genomic characterization of Kerstersia gyiorum SWMUKG01, an isolate from a patient with respiratory infection in China

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