The first clinical application of planning software for laparoscopic microwave thermosphere ablation of malignant liver tumours

Berber, Eren

doi:10.1111/hpb.12423

Cited by 17 publications

(13 citation statements)

References 10 publications

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“…In contrast to RFA, microwave probes provide faster tissue heating over a larger volume with a less prominent ‘heat sink effect’. With the latest generation microwave antenna, a spherical shaped ablation zone with a short axis diameter of up to 4 cm can be achieved [80]. Cryoablation is based on local tissue destruction based on very low temperatures inducing cellular dehydration, protein denaturation and microcirculatory failure [81].…”

Section: Resultsmentioning

confidence: 99%

Local Treatment of Breast Cancer Liver Metastasis

Bale

Putzer

Schullian

2019

Cancers

106

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Breast cancer represents a leading cause of death worldwide. Despite the advances in systemic therapies, the prognosis for patients with breast cancer liver metastasis (BCLM) remains poor. Especially in case of failure or cessation of systemic treatments, surgical resection for BCLMs has been considered as the treatment standard despite a lack of robust evidence of benefit. However, due to the extent and location of disease and physical condition, the number of patients with BCLM who are eligible for surgery is limited. Palliative locoregional treatments of liver metastases (LM) include transarterial embolization (TAE), transarterial chemoembolization (TACE), and selective internal radiotherapy (SIRT). Percutaneous thermal ablation methods, such as radiofrequency ablation (RFA) and microwave ablation (MWA), are considered potentially curative local treatment options. They are less invasive, less expensive and have fewer contraindications and complication rates than surgery. Because conventional ultrasound- and computed tomography-guided single-probe thermal ablation is limited by tumor size, multi-probe stereotactic radiofrequency ablation (SRFA) with intraoperative image fusion for immediate, reliable judgment has been developed in order to treat large and multiple tumors within one session. This review focuses on the different minimally invasive local and locoregional treatment options for BCLM and attempts to describe their current and future role in the multidisciplinary treatment setting.

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Section: Resultsmentioning

confidence: 99%

Local Treatment of Breast Cancer Liver Metastasis

Bale

Putzer

Schullian

2019

Cancers

106

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“…Ablation parameters were determined by using planning software (Fig. ) . This software enabled the surgeon to design the geometry of the ablation zones around the tumors preoperatively.…”

Section: Methodsmentioning

confidence: 99%

“…Ablation parameters were determined by using planning software ( Fig. 2) [15]. This software enabled the surgeon to design the geometry Conflict of interest: The authors disclose that we have no conflicts of interest or financial relationships to disclose.…”

Section: Surgical Techniquementioning

confidence: 99%

Laparoscopic microwave thermosphere ablation of malignant liver tumors: An analysis of 53 cases

Zaidi

Okoh

Yiğitbaş

et al. 2015

Journal of Surgical Oncology

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“…These factors may contribute to an altered approach of the liver anatomy and weaken the success of ablation by laparoscopy. Guidance systems and planning software may increase the accuracy of laparoscopic ablations by helping establish the optimal trajectory of the ablation probe and target the lesion more efficiently than with free-hand ultrasound guidance [17].…”

Section: Discussionmentioning

confidence: 99%

Local control of hepatocellular carcinoma and colorectal liver metastases after surgical microwave ablation without concomitant hepatectomy

Carvalho

Logghe

Cleven

et al. 2021

Langenbecks Arch Surg

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Purpose Microwave ablation (MWA) is an accepted technique in the multimodal treatment of hepatocellular carcinoma (HCC) and colorectal liver metastases (CRLM). Study endpoints were to evaluate the local efficacy of surgical MWA in selected patients with oligonodular disease without the combination of liver resection to allow a clear interpretation of the follow-up imaging and compare it to the results on percutaneous MWA available in the literature. Methods Consecutive MWA-only procedures performed between May 2013 and May 2018 for HCC and CRLM with free-hand ultrasound guidance were identified. MWA systems with 2450 MHz were used. Incomplete ablation (IA) was defined as residual disease within 1 cm of the ablation site at the first post-ablation imaging and local recurrence (LR) as the presence of disease after at least one tumor-free imaging. Results A total of 70 tumors in 47 patients were treated with 46 laparoscopic and 1 open procedures. Each patient had no more than 3 tumors, and median size of the lesions was 15 mm (IQR: 10-22). After a median follow-up of 26 months (IQR: 12-40), IA rate was 8.6% and LR rate was 29.4%. Multivariable analysis showed that vascular proximity (OR = 3.4; 95% CI = 1.26-9.22; p=0.016) was the only significant predictor of the combined outcome IA or LR. Discussion In the present study, after mostly laparoscopic MWA, LR was higher than the rates available in the literature for percutaneous MWA of HCC but lower than in the limited studies analyzing isolated percutaneous MWA of liver metastases. Future developments may help establish the role of each therapeutic modality per tumor, in order to improve the outcomes.

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The first clinical application of planning software for laparoscopic microwave thermosphere ablation of malignant liver tumours

Abstract: This study describes and validates pre-treatment planning software for MWA of liver tumours. This software was found useful to determine precisely the ablation parameters and needle placement to create a predicted zone of ablation.

Cited by 17 publications

References 10 publications

Local Treatment of Breast Cancer Liver Metastasis

Local Treatment of Breast Cancer Liver Metastasis

Laparoscopic microwave thermosphere ablation of malignant liver tumors: An analysis of 53 cases

Local control of hepatocellular carcinoma and colorectal liver metastases after surgical microwave ablation without concomitant hepatectomy

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