Substantial research on the topic of cultural heritage has been conducted over the past two decades. At the same time, the overall output volume of journals and citation metrics have become important parameters in assessing and ranking researchers’ performance. Even though the scholarly interest in cultural heritage has recently increased world-wide, a comprehensive analysis of the publication output volume and its correlation to the shift in the cultural heritage regime starting in 2003 is still lacking. The article aims to understand the role of Web of Science (WOS) as a tool of knowledge management in academia by drawing on the scholarly output volume, the patterns displayed by this volume, and the intellectual structure of cultural heritage research based on WOS-indexed journal articles. The data include 1843 journal articles published between 2003 and 2022 and indexed in the WOS Core Collection. The article draws on a bibliometric analysis by using WOS tools and employing VOSviewer software to map and visualize hidden patterns of research collaboration and avenues of knowledge progress. The cultural heritage research indexed in WOS was found to be Eurocentric, corresponding to the increasing funding provided by European national and supranational agencies for research funding. Although the indexed research has grown significantly, the bulk of studies on cultural heritage in WOS is concentrated in a reduced number of European institutions and countries, written by a small number of prolific authors, with relatively poor collaborative ties emerging across time between authors, institutions, and countries. The central themes reflect the development of digital technologies and increased participatory emphasis in cultural heritage care. This article brings new insights into the analysis of the cultural heritage research in correlation with the emergence of international heritage governance with new institutional actors, professional networks, and international agreements, which are all constitutive elements of scientific production. The article seeks to critically assess and discuss the results and the role of WOS as a tool of knowledge management in academia.