The first identification of contagious caprine pleuropneumonia (CCPP) in sheep and goats in Egypt: molecular and pathological characterization

Abdelrahman, Amir; Khafaga, Asmaa F.; Abas, Osama

doi:10.1007/s11250-019-02116-5

Cited by 13 publications

(15 citation statements)

References 29 publications

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“…However, there are some reports describing the isolation of Mcpp from sheep with respiratory disease returning to Eritrea with refugees from Sudan (Houshaymi et al, 2002) and from healthy sheep in Kenya that have been in contact with goat herds affected by CCPP (Litamoi et al, 1990). Isolation of Mccp has been also reported from sick sheep mixed with goats in Uganda (Bolske et al, 1995).The occurrence of CCPP was 32.5% and 5% in goats and sheep, respectively, while case fatality was 30 and 8% in goats and sheep, respectively reported by Abd-Elrahman et al (2019). In a serological survey for CCPP in Ethiopia, sheep tested were found to be sero-positive (Hadush et al, 2009;Teshome et al, 2018).…”

Section: Epidemiologymentioning

confidence: 90%

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Contagious caprine pleuropneumonia: A review

Teshome¹,

Sori²

2021

J. Vet. Med. Anim. Health

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The objective of this review is to generate information about the current status of contagious caprine pleuropneumonia (CCPP) which is recognized as highly infectious, and devastating disease of goats for about 140 years. However, current reports indicated that sheep can be affected. CCPP is caused by Mycoplasma capricolum subspecies capripneumoniae (Mccp) which is severe and dramatic mycoplasmas, challenging to isolate and properly identify. Coughing, respiratory distress and very high morbidity and mortality are the main clinical signs that described the disease. Transmission of CCPP occurs through aerosol while animals are in nearby contact. There are a number of approaches for the rapid detection and identification of Mccp based on a PCR. In Africa, Asia and Middle East morbidity and mortality can reach about 100% which causes huge economic loss. Presence of CCPP in Ethiopia reported in 1983 and later confirmed from an outbreak in 1990 in Ogaden, Eastern Ethiopia. Since then CCPP has been considered as endemic disease in Ethiopia. Prevention and control of CCPP is undertaken through vaccination, quarantine, restriction of movement, culling of infected and exposed animals and keeping the hygiene of premises. However, it remains one of the standing problems of goat production. Therefore, more research, awareness creation about CCPP, transmission path way, prevention and control methods, in small ruminant rearing areas to reduce the impact of the disease.

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Section: Epidemiologymentioning

confidence: 90%

“…Isolation of Mccp from cattle with mastitis has also been reported (Kumar and Garg, 1991) and these reports confound the perceived host specificity of this pathogen. In addition to serological, molecularly occurrence and case fatality of CCPP in sheep were a new record for Mccp in Egypt by (Abd-Elrahman et al, 2019).…”

Section: Epidemiologymentioning

confidence: 99%

Contagious caprine pleuropneumonia: A review

Teshome¹,

Sori²

2021

J. Vet. Med. Anim. Health

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“…103,105 Nevertheless, the use of marbofloxacin and spiramycin groups has been fruitful in the treatment of contagious caprine pleuropneumonia (CCPP), a similar disease in sheep and goats, as they produced a higher (70%) curative rate than the oxytetracycline group (40%) and a lower fatality rate (30%) than the oxytetracycline group (60%). 106 This treatment regiment can be used for CBPP mitigation in endemic herds.…”

Section: Control Strategiesmentioning

confidence: 99%

<p>Contagious Bovine Pleuropneumonia: Challenges and Prospects Regarding Diagnosis and Control Strategies in Africa</p>

Alhaji

Ankeli

Ikpa

et al. 2020

VMRR

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Contagious bovine pleuropneumonia (CBPP) is an infectious and contagious respiratory disease of cattle, caused by Mycoplasma mycoides subsp. mycoides (Mmm). In this review, basic epidemiological features of CBPP, complicated by existing different strains of Mycoplasmas with similar biochemical characteristics, with preference to Sub-Saharan Africa are discussed. Many sub-Saharan African countries are challenged by variable gaps that include diagnostic tools and control strategies. Science-based issues on diagnostic procedures, vaccination, treatment, and other control strategies are discussed. Participatory epidemiology (PE), a diagnostic technique used in the identification and solving of animal health problems in rural communities, was also discussed. PE application, in conjunction with conventional diagnostic tools, will improve CBPP identification in pastoral rural communities and promote control of the disease in Africa. Furthermore, adequate CBPP control can be achieved through stronger political commitments from governments by prioritizing the disease among major diseases of high economic importance to the livestock industry for surveillance and control. Investment in CBPP control in endemic African countries will assure food security, livelihoods and the general well-being of people, and international trade.

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“…Confirmation of Mccp is carried out by different methods, including microscopic examination of pulmonary exudation, histopathology of pulmonary parenchyma, molecular identification, and typing, namely, by polymerase chain reaction (PCR), detection of antigen in affected tissue by gel precipitin tests, and characterization by modern serological techniques [ 1 ]. The more recently developed methodologies include the latex agglutination test (LAT), competitive enzyme-linked immunosorbent assay, PCR, and restriction fragment length polymorphism [ 1 , 7 - 9 ]. Evaluation of cavity fluids including abdominal, thoracic, and pericardial effusions in the laboratory is beneficial for evaluating disease severity [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Alterations in acid-base balance, blood gases, and hematobiochemical profiles of whole-blood and thoracic fluid in goats with contagious caprine pleuropneumonia

Tadjine

2021

Vet World

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Background and Aim: Contagious caprine pleuropneumonia (CCPP) is a highly contagious and fatal disease affecting goats and some wild ruminants. It is a cause of major economic losses in the goat industry in Africa, Asia, and the Middle East. This study aimed to investigate the acid-base balance, blood gases, and hematobiochemical profiles of whole-blood and fluid collected from the thoracic cavity in goats with CCPP. Materials and Methods: Fifty-five goats suffering from weight loss, anorexia, dyspnea, polypnea, cough, and nasal discharges due to CCPP were studied. Twenty-five healthy goats were used as controls. Diseased animals were enrolled in this study based on a positive serological latex agglutination test (LAT) that confirmed the detection of Mycoplasma capricolum subsp. capripneumoniae. The control goats were enrolled based on a negative result of the LAT. Results: Compared with a mean value of 7.38±0.04 in controls, the pH in the diseased group was 7.41±0.05. The blood pressure of carbon dioxide (PCO2), pressure of oxygen (PO2), base excess (BE), bicarbonate (HCO3), total carbon dioxide (TCO2), and saturation of oxygen (SO2) were lower in goats with CCPP than in controls. However, the anion gap (AnGap) was higher in the diseased goats than in the healthy ones. Compared with the levels in blood samples, the thoracic fluid PCO2, PO2, BE, and SO2 were higher while pH, HCO3, TCO2, and AnGap were lower. Compared with the findings in healthy goats, hematological alterations included significant increases in white blood cells and neutrophils, and a significant decrease in the red blood cell count. In the thoracic fluid, neutrophilic leukocytosis was a remarkable finding. The serum concentrations of globulin, blood urea nitrogen, and glucose, and the activities of aspartate aminotransferase (AST) and γ-glutamyl transpeptidase (GGT) increased significantly compared with those in controls. In contrast, serum concentrations of albumin, calcium, and magnesium, and the activity of alkaline phosphatase (ALP) decreased significantly compared with those of healthy animals. The activities of ALP, AST, GGT, and creatine kinase and the concentration of phosphorus were higher in thoracic fluid than the serum values in the diseased group. Conclusion: When compared with the healthy controls, goats with CCPP have metabolic acidosis. Compared with the levels in healthy goats, the blood PCO2, PO2, BE, HCO3, TCO2, and SO2 are low in goats with CCPP; however, the AnGap is higher in diseased goats.

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The first identification of contagious caprine pleuropneumonia (CCPP) in sheep and goats in Egypt: molecular and pathological characterization

Cited by 13 publications

References 29 publications

Contagious caprine pleuropneumonia: A review

Contagious caprine pleuropneumonia: A review

<p>Contagious Bovine Pleuropneumonia: Challenges and Prospects Regarding Diagnosis and Control Strategies in Africa</p>

Alterations in acid-base balance, blood gases, and hematobiochemical profiles of whole-blood and thoracic fluid in goats with contagious caprine pleuropneumonia

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