2022
DOI: 10.14202/vetworld.2022.986-997
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The first study on the effect of crocodile oil from Crocodylus siamensis on hepatic mitochondrial function for energy homeostasis in rats

Abstract: Background and Aim: Consumption of fatty acids (FA) can alter hepatic energy metabolism and mitochondrial function in the liver. Crocodile oil (CO) is rich in mono-and polyunsaturated FAs, which have natural anti-inflammatory and healing properties. In rat livers, we investigated the effect of CO on mitochondrial function for energy homeostasis. Materials and Methods: Twenty-one male Sprague-Dawley rats were divided into three groups at random. Group 1 rats were given sterile water (RO), Group 2 rats were giv… Show more

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Cited by 5 publications
(5 citation statements)
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“…Our proteomic analysis revealed that unique proteins associated with energy metabolism (catalytic and metabolic activity) from the CO group showed a lesser extent from the normal group, but a greater proportion than that in the PO group. Consistent with our previous studies, CO improved hepatic mitochondrial morphology, the hepatic energy maintenance protein (23), and serum energy-related proteins (33) much better than the PO diet.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Our proteomic analysis revealed that unique proteins associated with energy metabolism (catalytic and metabolic activity) from the CO group showed a lesser extent from the normal group, but a greater proportion than that in the PO group. Consistent with our previous studies, CO improved hepatic mitochondrial morphology, the hepatic energy maintenance protein (23), and serum energy-related proteins (33) much better than the PO diet.…”
Section: Discussionsupporting
confidence: 92%
“…Our previous research has investigated that CO administration significantly lowered the total 24 surface area of triglyceride-rich lipid droplets in hepatocytes more than PO administration (23).…”
Section: Discussionmentioning
confidence: 99%
“…This finding suggested that CO, animal fat-source rich in MUFA and PUFA, could maintain metabolic health status. These results are consistent with our previous studies that revealed that CO exhibited a decrease in food intake, serum triglyceride levels, and the total surface area of lipid droplets in the hepatocyte [21,35]. Therefore, we suggested that the impact of CO on metabolic alterations may be associated with GM dysbiosis.…”
Section: Plos Onesupporting
confidence: 93%
“…Previous studies showed that CO exhibited effective improvement of skin rashes, wound healing, and anti-microbial activity [19,20]. Our previous study also demonstrated that CO supplementation could maintain energy metabolism in the liver by preserving hepatic mitochondrial structure and key energy maintaining protein [21]. Moreover, another study found that CO could help in liver detoxification by downregulating the expression of cytochrome P450 1A2 (CYP1A2) in high fat-fed rats [22].…”
Section: Introductionmentioning
confidence: 79%
“…This study aimed to investigate the effects of CO on the liver detoxification enzymes in rats by the oral administration of 1 and 3 ml per kg body weight of CO according to our previous studies [ 28 , 29 ]. Since 1 and 3 ml per kg body weight of CO was suggested to benefit liver function by increasing energy metabolites, including oxaloacetate, and 3 ml per kg body weight of CO also ameliorated hepatic steatosis of the rats, the doses of CO were selected to be used in this study.…”
Section: Discussionmentioning
confidence: 99%