The first surface micromachined pressure sensor for cardiovascular pressure measurements

Kälvesten, Edvard; Smith, Leif; Tenerz, L; Stemme, Göran

doi:10.1109/memsys.1998.659821

Cited by 77 publications

(61 citation statements)

References 8 publications

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“…Catheter tip-based pressure sensors are currently being manufactured and marketed for in vivo diagnosis of cardiovascular problems. 9,10 In applications like these as well as in most in vitro applications the issue of hemocompatibility of the MEMS materials is circumvented because the device's microfabricated mechanical structure (e.g., pressure sensing diaphragm, 10 flow channel, 8 or valve 6 ) is not in direct contact with blood. The relative thrombogenicity of the materials used in MEMS have therefore not been extensively documented.…”

Section: Introductionmentioning

confidence: 99%

Hemocompatibility of materials used in microelectromechanical systems: Platelet adhesion and morphology in vitro

Weisenberg

Mooradian

2002

J. Biomed. Mater. Res.

126

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Microelectromechanical systems (MEMS) create an opportunity for the development of smaller, cheaper, and more precise biomedical instrumentation and devices. Little is known, however, about the hemocompatibility of the materials used to fabricate these devices. Because of the potentially harmful consequences of thrombus formation, a better understanding of blood interactions with bioMEMS materials is desirable. This study is an in vitro assessment of the hemocompatibility of silicon (Si), silicon dioxide (SiO2), silicon nitride (Si3N4), low-stress silicon nitride (Si(1.0)N(1.1)), SU-8 photoresist, and parylene thin films. A polycarbonate-based polyurethane, was used as a reference material. Experiments were carried out to detect differences in platelet adhesion or morphology after contact with these materials under static conditions. Platelet adhesion on Si, Si3N4, Si(1.0)N(1.1,) and SU-8 photoresist was significantly greater (P < 0.05) than platelet adhesion on polyurethane. Adhesion on parylene and SiO(2) was not significantly different from on polyurethane (P < 0.05). The median platelet area and circularity were higher on polyurethane than all other materials. Materials that showed higher levels of platelet adhesion tended to have platelets that showed less spreading, except for SiO2, where platelets exhibited relatively low adhesion and spreading. This data suggests that Si, Si3N4, Si(1.0)N(1.1), and SU-8 photoresist may be more reactive to platelets and therefore more thrombogenic than parylene, SiO2, and polyurethane. These results may be helpful in guiding the selection of materials for use in the development of blood-contacting microelectromechanical systems.

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Section: Introductionmentioning

confidence: 99%

Hemocompatibility of materials used in microelectromechanical systems: Platelet adhesion and morphology in vitro

Weisenberg

Mooradian

2002

J. Biomed. Mater. Res.

126

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“…In fact, the most important achievement in the following years was the implementation of microfabrication techniques. [127][128][129][130][131] The configuration proposed by Lekholm and Lindström 40,45 was also the basis for the development of Camino pressure sensors (San Diego, California). This transducer-tipped catheter consisted of a 1.35-mm OD tip enclosed in a saline-filled sheath (2.1-mm OD) with side holes (Fig.…”

Section: Intravascular and Intracardiac Pressurementioning

confidence: 99%

Review of fiber-optic pressure sensors for biomedical and biomechanical applications

Roriz

Frazão

Ribeiro³

et al. 2013

J. Biomed. Opt

196

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Abstract. As optical fibers revolutionize the way data is carried in telecommunications, the same is happening in the world of sensing. Fiber-optic sensors (FOS) rely on the principle of changing the properties of light that propagate in the fiber due to the effect of a specific physical or chemical parameter. We demonstrate the potentialities of this sensing concept to assess pressure in biomedical and biomechanical applications. FOSs are introduced after an overview of conventional sensors that are being used in the field. Pointing out their limitations, particularly as minimally invasive sensors, is also the starting point to argue FOSs are an alternative or a substitution technology. Even so, this technology will be more or less effective depending on the efforts to present more affordable turnkey solutions and peer-reviewed papers reporting in vivo experiments and clinical trials. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…Nevertheless, tip and side-hole configurations have been adopted up to today. In fact, the most important achievement in the following years was miniaturization of sensor probes using microfabrication techniques [49][50][51][52][53]. Besides intravascular pressure measurement, similar intensity-modulated configurations to the one proposed by Lekholm and Lindström [37,39] have been explored to measure pressure in other sites of the human body.…”

Section: Earlier Intensity-modulated Configurationsmentioning

confidence: 99%

Fiber optic intensity-modulated sensors: a review in biomechanics

et al. 2012

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Fiber optic sensors have a set of properties that make them very attractive in biomechanics. However, they remain unknown to many who work in the field. Some possible causes are scarce information, few research groups using them in a routine basis, and even fewer companies offering turnkey and affordable solutions. Nevertheless, as optical fibers revolutionize the way of carrying data in telecommunications, a similar trend is detectable in the world of sensing. The present review aims to describe the most relevant contributions of fiber sensing in biomechanics since their introduction, from 1960s to the present, focusing on intensity-based configurations. An effort has been made to identify key researchers, research and development (R&D) groups and main applications.

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The first surface micromachined pressure sensor for cardiovascular pressure measurements

Cited by 77 publications

References 8 publications

Hemocompatibility of materials used in microelectromechanical systems: Platelet adhesion and morphology in vitro

Hemocompatibility of materials used in microelectromechanical systems: Platelet adhesion and morphology in vitro

Review of fiber-optic pressure sensors for biomedical and biomechanical applications

Fiber optic intensity-modulated sensors: a review in biomechanics

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