The first visually observable three-mode antibiotic switch and its relative 3D printing assisted applications

Liu, Miaoxing; Fang, Fang; Song, Xiangwei; Yu, Fen; Li, Fengshun; Shi, Xiaotong; Xue, Chaowen; Chen, Tingtao; Wang, Xiaolei

doi:10.1039/c6tb00576d

Cited by 8 publications

(12 citation statements)

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“…31 More importantly, the antibacterial properties of these nanocomposites were also improved compared to the similar sized bare Ag nanoparticles. 26 These experimental results showed that 4× NaCl was the ideal dose to adjust Ag-C size and metabolism. However, the detailed mechanism remains to be further explored.…”

Section: Discussionmentioning

confidence: 78%

“…In previous work, it was found that when PBS existed in vitro, Ag-C could effectively switch from the monodispersed to the aggregated mode. 26 In this work, in order to achieve effective switch and rapid metabolism of Ag-C material in vivo, the metal salts in PBS triggering the switch were studied. The three main components of PBS, which are NaCl, KCl, and K 2 HPO 4 , were mixed with Ag-C and then the UV-vis absorption spectra were measured.…”

Section: Discussionmentioning

confidence: 99%

“…26 Briefly, 3.03 g PSTT was prepared in a tube furnace at 400°C for 6 h at a heating rate of 10°C/min under an N 2 atmosphere. Once the product cooled to room temperature, it was dispersed in 80 mL deionized water in the dark, ultrasound dispersed (700 W) for 60 min, and centrifuged at 9,500 rpm/min for 16 min to remove large, insoluble particles.…”

Section: Preparation Of the Carbon Dots (Cds)mentioning

confidence: 99%

“…In the previous study, 26 we found that the use of different concentrations of PBS solution could trigger the three modes of transformation of carbon membrane packaged Ag nanoparticles (Ag-C), ie, the packaging, the activation, and the deactivation. Therefore, the purpose of controlling the antibacterial activities of SBNs could be achieved.…”

mentioning

confidence: 99%

“…However, its detailed mechanism is not certain at the moment as there is no guarantee that this same adjustment could also be realized in the in vivo situation. In a combined effort based on other teams' former investigations, [26][27][28] a new kind of Ag-C was firstly synthesized, after which we investigated how to adjust the mode, switching from activation to aggregation more effectively. The metabolism of the obtained SBNs was also discussed in in vivo applications of this mode switch.…”

mentioning

confidence: 99%

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NaCl: for the safer in vivo use of antibacterial silver based nanoparticles

Liu¹,

Zhang²,

Song³

et al. 2018

IJN

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Background As antibiotics progressively cease to be effective, silver based nanoparticles (SBNs), with broad antibacterial spectrum, might be the last line of defense against malicious bacteria. Unfortunately, there are still no proper SBNs-based strategies for in vivo antibacterial therapies. In this article, new carbon membrane packaged Ag nanoparticles (Ag-C) were synthesized. We assessed the effect of Ag-C with NaCl on size, cytotoxicity, antibacterial properties, metabolism and sepsis models. Methods The size of Ag-C with NaCl was accessed with UV-vis, TEM and SEM. Staphylococcus aureus , Escherichia coli and Pseudomonas aeruginosa were used to illustrate the antibacterial properties of SBNs affected by NaCl. L929 and 3T3 cell lines were cultured in vitro; CCK-8 assay was used to test cytotoxicity. Then, we explored the metabolism of Ag-C with NaCl in vivo. Finally, the effect of Ag-C with 4× NaCl on sepsis was observed. Results NaCl could regulate the size of Ag-C. Ag-C exhibited superior antibacterial properties compared to similar sized pure Ag nanoparticles. Furthermore, the addition of NaCl could not only reduce the cytotoxicity of Ag-C, but could also continue to discharge Ag-C from major organs. Based on these factors, this method was used to treat a sepsis model (induced via cecal ligation and puncture), and it achieved satisfactory survival results. Conclusion This discovery, though still in its infancy, could significantly improve the safety and feasibility of SBNs and could potentially play an important role in modern in vivo antibacterial applications. Thus, a new method to combating the growing threat from drug-resistant bacteria could be possible. NaCl is the key to excretion of SBNs after in vivo antibacterial use.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Preparation Of the Carbon Dots (Cds)mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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