The firstH- 2 mutant workshop

Kohn, Henry I.; Klein, Jan; Melvold, Roger W.; Nathenson, Stanley G.; Pious, Donald; Shreffler, Donald C.

doi:10.1007/bf01844019

Cited by 87 publications

(48 citation statements)

References 46 publications

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“…Analysis of our data show that although in most cases the residual cytotoxicity exerted by the nonadherent subsets of CTL follows the presence or absence of public specificities, in two cases (Table III, C3H.OL targets) residual cytotoxicity was observed, although no public specificities should have been detected. This finding is in accordance with the fact that CTL can be developed between serologically identical H-2 mutants, suggesting that other determinants than those recognized by alloantibodies could act as targets for CTL (18). However, it has been recently suggested that antibodies could be raised between such mutants by using appropriate immunization (18).…”

Section: Adsorption Of B I Obr Anti-b L Oa Ctl On Macrophage Monolasupporting

confidence: 75%

“…This finding is in accordance with the fact that CTL can be developed between serologically identical H-2 mutants, suggesting that other determinants than those recognized by alloantibodies could act as targets for CTL (18). However, it has been recently suggested that antibodies could be raised between such mutants by using appropriate immunization (18).…”

Section: Adsorption Of B I Obr Anti-b L Oa Ctl On Macrophage Monolasupporting

confidence: 75%

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Separate cytotoxic T lymphocyte subsets recognize the different H-2 specificities.

Vázquez¹,

Néauport–Sautès²,

Sénik³

1980

The Journal of Experimental Medicine

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Using a monolayer adsorption technique, the fine specificity of cytotoxic effector T lymphocytes (CTL) generated against allogeneic or semi-allogeneic H-2 haplotypes was investigated. The results show that: (a) CTL reacting with the private specificity expressed on an H-2.K molecule can be separated from those reacting with the public specificities expressed on the same molecule and (b) the CTL that recognize cross-reacting H-2 determinants (public specificities) can also be separated into several subpopulations. These data support the hypothesis that an allogeneic stimulation induces a large number of independent T cell clones that react with H-2 determinants.

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Section: Adsorption Of B I Obr Anti-b L Oa Ctl On Macrophage Monolasupporting

confidence: 75%

Section: Adsorption Of B I Obr Anti-b L Oa Ctl On Macrophage Monolasupporting

confidence: 75%

Separate cytotoxic T lymphocyte subsets recognize the different H-2 specificities.

Vázquez¹,

Néauport–Sautès²,

Sénik³

1980

The Journal of Experimental Medicine

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“…The stud males were either B6.CH_2bml or B6/By (H-2b). The bml mutation arose in a (B6/By X BALB/c)F, hybrid and was introduced into the B6/By strain by serial backcrossing to derive the congenic B6.C-H-2bml strain (10). Thus, the only evident genetic difference between these two strains is in the H-2K gene, and the only known structural difference is in the H-2K cell-surface glycoprotein-namely, amino acid substitutions at positions 152, 155, and 156, corresponding to differences within a sequence of 13 nucleotides within H-2K (11,12).…”

mentioning

confidence: 99%

Influence of a genetic difference confined to mutation of H-2K on the incidence of pregnancy block in mice.

Yamazaki¹,

Beauchamp²,

Matsuzaki³

et al. 1986

Proc. Natl. Acad. Sci. U.S.A.

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In mice, pregnancy is often terminated when the stud male is removed and the pregnant female is exposed to the presence or scent of an unfamiliar male. It is reported here that the incidence of such blocking of pregnancy was higher when the stud and unfamiliar male differed by mutation of the H-2K class I gene of the major histocompatibility complex than when the stud and unfamiliar males were genetically identical. Thus, the olfactory distinction of mice differing by mutation of the H-2K gene, previously demonstrated after training of mice in a Y maze, can spontaneously influence neuroendocrine communications affecting reproduction.The olfactory sensing of major histocompatibility complex (MHC) has been shown to influence the reproductive behavior of mice in two respects. First, mice exhibit mating preferences that generally favor matings between MHCdissimilar pairs rather than MHC-identical pairs (1-4). Second, the incidence of pregnancy block, whereby pregnancy may be terminated when pregnant females are exposed to the scent of an unfamiliar male (the Bruce effect), is higher when the MHC type of the unfamiliar male differs from that of the stud male (5).The extended MHC of the mouse comprises a linked series of several genes, known as H-2:Qa:Tla, situated on chromosome 17. In addition to the observations of MHC-associated mating preferences and of MHC-associated incidences of blocked pregnancy mentioned above, the sensing of mouse

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“…Singer, Bethesda, MD. The mouse strains used in this study, their H-2 haplotypes, and the structural alterations in the H-2 molecules of the mutant mouse strains are listed in Table I ( [33][34][35][36][37].…”

Section: Methodsmentioning

confidence: 99%

Thymus dictates major histocompatibility complex (MHC) specificity and immune response gene phenotype of class II MHC-restricted T cells but not of class I MHC-restricted T cells.

Kast¹,

Waal²,

Melief³

1984

The Journal of Experimental Medicine

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Athymic H-2b nude mice received grafts from C57BL/6 (Sendai virus and H-Y antigen cytotoxic T lymphocyte [CTL] responder type), bm1 (H-2Kb mutant, Sendai CTL nonresponder type), or bm12 (H-21-A mutant, H-Y CTL nonresponder type) neonates. In observations of the CTL response to H-Y, both recipients and thymus donors were female. All types of thymus engraftment resulted in mature H-2b splenic T lymphocyte surface phenotype in nude hosts. T cell immunocompetence (as measured by major histocompatibility complex [MHC] CTL responses to allogeneic cells) was restored, and induced nonresponsiveness to the MHC determinants of the engrafted thymus in the nude host. The CTL reaction to Sendai virus in both responder type C57BL/6 and nonresponder type bm1 neonatal thymuses allowed maturation of Sendai-specific, H-2Kb-restricted CTL. For the CTL reaction to H-Y, only responder type C57BL/6 thymuses restored the CTL response, whereas this was not achieved with thymuses from nonresponder type bm12 neonatal females. Results of double thymus (B6 and bm12) engraftment excluded the possibility that this latter effect was caused by suppression. In addition, athymic bm1 mice were engrafted with thymuses from either B6 (Sendai CTL responder type) or syngeneic bm1 neonates (Sendai CTL nonresponder type). Again, both types of neonate thymuses restored T cell competence as measured by MHC/CTL responses to allogeneic cells. However, neither responder B6 nor nonresponder bm1 neonate thymus grafts allowed maturation of Sendai-specific CTL. In conclusion, the thymus dictates MHC specificity and immune response gene phenotype of T cells restricted to class II MHC molecules but not of T cells restricted to class I MHC molecules.

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The firstH- 2 mutant workshop

Cited by 87 publications

References 46 publications

Separate cytotoxic T lymphocyte subsets recognize the different H-2 specificities.

Separate cytotoxic T lymphocyte subsets recognize the different H-2 specificities.

Influence of a genetic difference confined to mutation of H-2K on the incidence of pregnancy block in mice.

Thymus dictates major histocompatibility complex (MHC) specificity and immune response gene phenotype of class II MHC-restricted T cells but not of class I MHC-restricted T cells.

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