This paper engages the relationship between toxic geographies and settler colonialism. By bringing to light larger structures and histories that underpin the settler colonial project, I examine a series of toxic encounters and consider the racialised hegemonic narratives that enable the production toxicity. Among these is a methylmercury contamination in Northern Ontario, just upstream from Grassy Narrows First Nation, and a cluster of toxic conversations that bled through social media in the wake of the murder of Colten Boushie, a 22‐year‐old Cree man in Saskatchewan, Canada. I argue that examining the normative ideologies, settler narratives, and socio‐political structures that are involved in the production of toxicity provides valuable insight into the diffuse and relational colonial logics that define the lives that are privileged as the standard, and those that fall outside the regulatory category of the Human, and as a result, are subject to elimination.