The “Five-flap” Technique for Nipple–Areola Complex Reconstruction

Ferraro, Giuseppe; Lanzano, Giuseppe; Gentile, Corrado; Izzo, Sara; Grella, E; Gubitosi, Adelmo; Nicoletti, Giovanni Francesco

doi:10.1097/gox.0000000000003917

Cited by 8 publications

(9 citation statements)

References 25 publications

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“…Currently, there is no standard therapy for their treatment, but several studies and progress have been made in this field 25 . The most effective treatment remains the combination of different therapies such as intralesional steroids (triamcinolone), surgical excision, silicone gel and others 25‐30 …”

Section: Discussionmentioning

confidence: 99%

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Parecoxib decreases cellular growth and Bcl‐2 protein levels in primary cultures of keloid fibroblasts

Grella,

Lanzano,

Faenza

et al. 2024

International Wound Journal

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Keloids seem to overexpress cyclo‐oxygenase‐2 (COX‐2), suggesting a role in its deregulated pathway in inducing an altered epithelial‐mesenchymal interaction, which may be responsible for the overgrowth of dermal components resulting in scars or keloid lesions. This study aimed to evaluate the effect of Parecoxib, a COX‐2 inhibitor, on cell growth in fibroblast primary cultures obtained from human keloid tissues. Tissue explants were obtained from patients who underwent intralesional excision of untreated keloids; central fractions were isolated from keloid tissues and used for establishing distinct primary cultures. Appropriate aliquots of Parecoxib, a COX‐2 inhibitor were diluted to obtain the concentration used in the experimental protocols in vitro (1, 10 or 100 μM). Treatment with Parecoxib (at all concentrations) caused a significant decrease in cellular growth from 24 hours onwards, and with a maximum at 72 hours (P < .02). Moreover, at 72 hours Parecoxib significantly reduced cellular vitality. Parecoxib treatment also induced an increase in fragmented nuclei with a maximum effect at 100 μM and a significant decrease in Bcl‐2 and an increase in activated caspase‐3 protein levels at 72 hours compared with control untreated cultures. Our findings suggest a potential use of the COX‐2 inhibitor, Parecoxib, as the therapy for keloids.

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Section: Discussionmentioning

confidence: 99%

“… 25 The most effective treatment remains the combination of different therapies such as intralesional steroids (triamcinolone), surgical excision, silicone gel and others. 25 , 26 , 27 , 28 , 29 , 30 …”

Section: Discussionmentioning

confidence: 99%

Parecoxib decreases cellular growth and Bcl‐2 protein levels in primary cultures of keloid fibroblasts

Grella,

Lanzano,

Faenza

et al. 2024

International Wound Journal

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“…We have experienced that the round block technique to confine the scar in the areola creates several problems: scar widening, suture infection (especially using braided suture), decubitus phenomena, changes in areola shape, and rupturing of necessary nonabsorbable suture. [25][26][27] Indeed, the periareolar technique usually entails the closure of the defect under tension for the inevitable discrepancy between the areola diameter and the outer edge of the wound circumference; this problem occurs also when some of the discrepancy is compensated by vertical skin take-out. This often leads to areolar distortions, scar widening, and hypertrophic scarring, 27 and it is a well-known setup for litigation with an unfavorable outcome for the surgeon.…”

Section: Discussionmentioning

confidence: 99%

Tuberous Breast Management: A Review of Literature and Novel Technique Refinements

Grella

D’Andrea

Nicoletti

et al. 2022

Plastic and Reconstructive Surgery - Global Open

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Background: The tuberous breast is a rare malformation that can affect psychosocial well-being in young women. Its management represents a great challenge to plastic surgeons. Many surgical procedures have been described to correct different grades of tuberous breast deformity (TBD). The authors describe their one-stage technique for correcting grade 2 TBD. Methods: Sixteen women affected by grade 2 TBD treated with glandular flaps, silicone gel prosthesis, and only an hemiperiareolar incision between January 2018 and January 2019 were reviewed. The age range was 19–27 years (mean age was 25). Follow-up average was 25 months (range 16–33 months). To evaluate the results, we used two analogic scales with values from 1 to 3, where the lower value was the worst result. First, an independent medical team of three plastic surgeons evaluated two parameters: correction of deformity and symmetry. Then, patients were asked to judge the result obtained. Results: The resulting breast has a normal-shaped areola without bulging, a natural shape, a volume matching the contralateral breast, and no evidence of “double-bubble” deformity or irregularities of the lower pole shape. Conclusion: We propose this one-stage approach with hemiperiareolar incision, to minimize time interval to obtain final results in TBD correction, with reduced scar dimensions to avoid all the possible complications related to the round block suture.

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“…Unfortunately, such practices can cause severe complications at the donor site. Typical donor-site comorbidities include infections, dehiscence (wound separation), hematomas, restricted movement, chronic pain, and loss of function (Ferraro et al, 2022). The aesthetic outcomes of these surgical procedures often have severe social and psychological impacts on the patients (Honigman et al, 2004).…”

Section: Blood Vesselsmentioning

confidence: 99%

From waste to wealth: Repurposing slaughterhouse waste for xenotransplantation

Khan

Khraibi

Dumée

et al. 2023

Front. Bioeng. Biotechnol.

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Slaughterhouses produce large quantities of biological waste, and most of these materials are underutilized. In many published reports, the possibility of repurposing this form of waste to create biomaterials, fertilizers, biogas, and feeds has been discussed. However, the employment of particular offal wastes in xenotransplantation has yet to be extensively uncovered. Overall, viable transplantable tissues and organs are scarce, and developing bioartificial components using such discarded materials may help increase their supply. This perspective manuscript explores the viability and sustainability of readily available and easily sourced slaughterhouse waste, such as blood vessels, eyes, kidneys, and tracheas, as starting materials in xenotransplantation derived from decellularization technologies. The manuscript also examines the innovative use of animal stem cells derived from the excreta to create a bioartificial tissue/organ platform that can be translated to humans. Institutional and governmental regulatory approaches will also be outlined to support this endeavor.

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The “Five-flap” Technique for Nipple–Areola Complex Reconstruction

Cited by 8 publications

References 25 publications

Parecoxib decreases cellular growth and Bcl‐2 protein levels in primary cultures of keloid fibroblasts

Parecoxib decreases cellular growth and Bcl‐2 protein levels in primary cultures of keloid fibroblasts

Tuberous Breast Management: A Review of Literature and Novel Technique Refinements

From waste to wealth: Repurposing slaughterhouse waste for xenotransplantation

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