The flavonoid 7-mono-O-(β-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effect

Lemmens, Kristien J.A.; Wier, Bregje van de; Vaes, Nathalie; Ghosh, Mitrajit; Zandvoort, Marc A. M. J. van; Vijgh, W.J.F. van der; Bast, Aalt; Haenen, Guido R.M.M.

doi:10.1016/j.tiv.2013.12.019

Cited by 21 publications

(27 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1), which is similar to previously reported values [12]. The k s of methylmonoHER obtained is 110 Â 10 8 M À1 s À1 .…”

Section: Hydroxyl Radical Scavenging Activitysupporting

confidence: 91%

“…It has been reported that the high hydroxyl radical scavenging activity of monoHER is due to its ability to chelate iron. This results in site-specific scavenging of radicals [12]. The hydroxyl radical scavenging assay shows that methylmonoHER is not able to site-specifically scavenge the hydroxyl radicals, indicating that methylmonoHER lacks the iron chelating ability of monoHER.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

The contribution of the major metabolite 4′-O-methylmonoHER to the antioxidant activity of the flavonoid monoHER

Lemmens¹,

Herst²,

Housmans³

et al. 2015

Chemico-Biological Interactions

Self Cite

View full text Add to dashboard Cite

“…1), which is similar to previously reported values [12]. The k s of methylmonoHER obtained is 110 Â 10 8 M À1 s À1 .…”

Section: Hydroxyl Radical Scavenging Activitysupporting

confidence: 91%

Section: Discussionmentioning

confidence: 97%

The contribution of the major metabolite 4′-O-methylmonoHER to the antioxidant activity of the flavonoid monoHER

Lemmens¹,

Herst²,

Housmans³

et al. 2015

Chemico-Biological Interactions

Self Cite

View full text Add to dashboard Cite

“…Alternatively, it is possible that in vivo flow‐mediated endothelial factors may have overruled the ex vivo interaction between tamsulosin and quercetin. Using in vivo imaging techniques, it was found that 7‐mono‐ O ‐(β‐hydroxyethyl)‐rutoside, a semi‐synthetic derivative of quercetin, was present inside the endothelial cells of intact arteries (Lemmens et al, ). The significance of this observation needs further exploration.…”

Section: Discussionmentioning

confidence: 99%

“…Alternatively, it is possible that in vivo flow-mediated endothelial factors may have overruled the ex vivo interaction between tamsulosin and quercetin. Using in vivo imaging techniques, it was found that 7-mono-O-(β-hydroxyethyl)rutoside, a semi-synthetic derivative of quercetin, was present inside T A B L E 1 Metabolic and haemodynamic effects of oral transient feeding of quercetin in pre-hypertensive spontaneously hypertensive rats from weeks 4 to 8 of age the endothelial cells of intact arteries (Lemmens et al, 2014) While the addition of 0.1% quercetin through the regular rat chow led to biologically effective plasma concentrations of quercetin (Boots et al, 2011), the treatment regimen was associated with significant reductions in food and water intake in young pre-hypertensive SHR.…”

Section: Study 2: Regional Vascular Effects Of Quercetin In the Absmentioning

confidence: 99%

Haemodynamic effects of the flavonoid quercetin in rats revisited

Vrolijk

Essen

Opperhuizen

et al. 2020

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

Background and Purpose The flavonoid quercetin increased the in vitro potency of the α1‐antagonist tamsulosin to reduce phenylephrine‐dependent arterial contractions by 10‐fold. To examine if this supplement–drug interaction luxates hypotensive and orthostatic events in vivo, several set of studies were conducted in spontaneously hypertensive (SHR) and normotensive (Wistar Kyoto [WKY]) rats. Experimental Approach First, in rats pretreated with quercetin or its vehicle, responses to phenylephrine and tamsulosin were examined. Second, tamsulosin‐induced changes in renal, mesenteric, hindquarter and carotid conductance were compared in quercetin‐ and vehicle‐treated rats instrumented with Doppler flow probes. Animals were also placed on a tilt table to record regional haemodynamic changes to orthostatic challenges. Third, adult SHR were instrumented with telemeters to measure 24‐hr patterns of BP. Recordings were made before and during a 5‐week oral treatment of quercetin. Finally, pre‐hypertensive SHR were treated with quercetin from 4 to 8 weeks of age and arterial pressure was measured at 8 and 12 weeks. Key Results Pretreatment with quercetin did not influence the responses to phenylephrine and tamsulosin, in neither WKY nor SHR. While tamsulosin treatment and tilting lowered BP and increased conductance in all vascular beds, effect size was not influenced by pretreatment with quercetin. Prolonged treatment with quercetin, in either prehypertensive SHR or adult SHR with established hypertension did not lower BP. Conclusions and Implications Cumulatively, these data demonstrate that quercetin does not amplify haemodynamic effects of tamsulosin or tilting in vivo in rats and has no effect on BP development in SHR.

show abstract

“…17 The effect was found to be instantaneous and was attributed to its ability to directly scavenge radicals. Oxidative stress was induced to endothelial cells by addition of Kang et al 18 found that three flavonoids isolated from bitter oranges, namely nobiletin, naringin and hesperidin, also displayed anti-inflammatory properties when administered to LPS-stimulated murine macrophage cells.…”

Section: Lemmens Et Al Found That 7-mono-o-(-hydroxyethyl)-rutoside Amentioning

confidence: 99%

Flavonoids – Small Molecules, High Hopes

Sandu¹,

Birsa

Bahrin

2017

Acta Chemica Iasi

View full text Add to dashboard Cite

This brief review takes a look at flavonoids, a wide class of polyphenols, which are regarded as plant secondary metabolites. Their roles in plants are diverse and little understood. They can act as growth hormone modulators, phytoalexins, they offer UV protection, contribute to pollen viability and can function as signaling molecules in establishing symbiotic relationships. Flavonoids were also found to have a range of beneficial effects for the human body. Their anticancer, antioxidant, anti-inflammatory and cardioprotective activity, as well as their antibacterial, antiviral and antihelmintic properties make them promising candidates for the design of new drugs.

show abstract

The flavonoid 7-mono-O-(β-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effect

Cited by 21 publications

References 29 publications

The contribution of the major metabolite 4′-O-methylmonoHER to the antioxidant activity of the flavonoid monoHER

The contribution of the major metabolite 4′-O-methylmonoHER to the antioxidant activity of the flavonoid monoHER

Haemodynamic effects of the flavonoid quercetin in rats revisited

Flavonoids – Small Molecules, High Hopes

Contact Info

Product

Resources

About