The flavonoid luteolin suppresses infantile hemangioma by targeting FZD6 in the Wnt pathway

Dai, Yujian; Zheng, Huiming; Liu, Zhen; Wang, Yingjun; Hu, Weize

doi:10.1007/s10637-020-01052-8

Cited by 11 publications

(9 citation statements)

References 26 publications

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“…Liu et al (2024) demonstrated that luteolin not only enhances the structural integrity of cartilage and promotes tissue repair in mice with arthritis but also suppresses the expression of COX-2 and matrix metalloproteinase 1 (Mmp1), while simultaneously upregulating collagen protein expression [33]. Furthermore, luteolin not only enhances muscle strength in fatigued subjects and improves skeletal muscle contraction during ischemia-reperfusion [34], but also inhibits VEGFA and affects microvascular network formation during mouse angiogenesis [35].…”

Section: Discussionmentioning

confidence: 99%

Integrated Bioinformatics, Network Pharmacology and Molecular Docking to Explore the Mechanisms of Taohong Siwu Decoction in the Treatment of Tendinopathy

Li,

Pan

2024

Preprint

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Objective: This study aims to investigate the potential mechanism of Taohong Siwu Decoction (THSWD) in the treatment of tendinopathy using bioinformatics, network pharmacology, and molecular docking methods. Methods: The human tendinopathy expression microarray dataset was obtained from the GEO database. Bioinformatics methods were employed to screen differentially expressed genes. Disease-associated genes related to tendinopathy were identified using relevant databases. Potential targets of THSWD for treating tendinopathy were identified and subjected to functional and pathway enrichment analysis. A protein-protein interaction (PPI) network of potential therapeutic targets was constructed, along with a drug components-disease target-signaling pathway network. Results: A total of 867 tendinopathy-related targets were confirmed, while 45 active ingredients of THSWD resulted in retrieval of 216 corresponding tendinopathy targets. THSWD primarily modulates signaling pathways such as IL-17 signaling pathway, TNF signaling pathway, AGE-RAGE signaling pathway associated with diabetic complications, as well as other signaling pathways for effective treatment of tendinopathy. Molecular docking simulations demonstrated high binding activity between core active compounds and hub genes. Conclusion: The therapeutic effect of THSWD on tendinopathy is achieved through a multi-component, multi-target, and multi-pathway approach involving primarily the IL-17 signaling pathway, TNF signaling pathway, and AGE-RAGE signaling pathway in diabetic complications.

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Section: Discussionmentioning

confidence: 99%

Integrated Bioinformatics, Network Pharmacology and Molecular Docking to Explore the Mechanisms of Taohong Siwu Decoction in the Treatment of Tendinopathy

Li,

Pan

2024

Preprint

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“…In this study, luteolin targeted VEGFA, MMP2, MET, and EGFR. Luteolin inhibits VEGFA and affects microvascular networks formed during neovascularization in mice [ 45 ]. In tumors, luteolin inhibits MMP2 and MET [ 46 – 48 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Potential Mechanisms of Melilotus officinalis (L.) Pall. in Chronic Muscle Repair Patterns Using Single Cell Receptor-Ligand Marker Analysis and Molecular Dynamics Simulations

et al. 2022

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Information regarding the function of Melilotus officinalis (L.) Pall. in skeletal muscles is still unknown. In this study, we explored the possible regulatory targets of M. (L.) Pall. that affects the repair patterns in chronic muscle injury. We analyzed the potential target genes and chemical composition of M. (L.) Pall. and constructed a “drug-component-disease target genes” network analysis. Five active ingredients and 87 corresponding targets were obtained. Muscle-tendon junction (MTJ) cells were used to perform receptor-ligand marker analysis using the CellphoneDB algorithm. Targets of M. (L.) Pall. were screened further for the cellular ligand-receptor protein action on MTJs. Enrichment analysis suggests that those protein-associated ligand receptors may be associated with a range of intercellular signaling pathways. Molecular docking validation was then performed. Five proteins (CCL2, VEGFA, MMP2, MET, and EGFR) may be regulated by the active ingredient luteolin and scoparone. Finally, molecular dynamics simulations revealed that luteolin can stably target binding to MMP2. M. (L.) Pall. influences skeletal muscle repair patterns by affecting the fibroblast interactions in the muscle-tendon junctions through the active ingredients luteolin and scoparone.

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“…VEGFA, a key target of vascular endothelial cell proliferation, promotes DED corneal neovascularization [35]. The effect of luteolin on VEGFA expression in DED is unknown, but luteolin can inhibit VEGFA expression in hemangioma-derived stem cells (HemSCs) [36]. Inflammation is an important pathogenesis of The larger the node, the darker the color, and the more important the target is.…”

Section: Discussionmentioning

confidence: 99%

Using Network Pharmacology and Molecular Docking to Explore the Mechanism of Qiju Dihuang Pill against Dry Eye Disease

Zhao

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. Dry eye disease (DED) is a multifactorial disease of the ocular surface, which affects the quality of life and work efficiency of affected patients. The traditional Chinese medicine formula Qiju Dihuang Pill (QJDHP) has a good therapeutic effect on DED. However, the pharmacological mechanism is not clear. Objective. To explore the mechanism of QJDHP in the treatment of DED based on network pharmacology. Method. The active components in QJDHP were screened in Traditional Chinese Medicine Systems Pharmacology (TCMSP), and putative molecular targets of QJDHP were identified using the SwissTargetPrediction database. DED-related targets were screened by GeneCards and OMIM. We established protein-protein interaction (PPI) and core targets and corresponding active compound network by Cytoscape to identify the core targets and main compounds of QJDHP against DED. DAVID database was utilized for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Molecular docking was used to evaluate the binding activity between key active compounds and core targets. Results. The results of network pharmacology showed that 253 targets of QJDHP were related to DED. PPI network analysis showed the 18 core targets. The binding affinity of docking results ranged from -5.7 to -9.3 kcal/mol, indicating a good docking effect. The results of GO enrichment analysis showed that the mechanism of QJDHP in the treatment of DED mainly involved biological processes such as apoptosis, oxidative stress, response to estrogen, angiogenesis, and the regulation of transcription factors. KEGG analysis showed that QJDHP may be regulated by the TNF signaling pathway, Toll-like receptor signaling pathway, MAPK signaling pathway, and estrogen signaling pathway in the treatment of DED. Conclusion. In this study, we demonstrated the multicomponent, multitarget, and multichannel action mechanism of QJDHP in the treatment of DED and provided a foundation for further drug development research.

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The flavonoid luteolin suppresses infantile hemangioma by targeting FZD6 in the Wnt pathway

Cited by 11 publications

References 26 publications

Integrated Bioinformatics, Network Pharmacology and Molecular Docking to Explore the Mechanisms of Taohong Siwu Decoction in the Treatment of Tendinopathy

Integrated Bioinformatics, Network Pharmacology and Molecular Docking to Explore the Mechanisms of Taohong Siwu Decoction in the Treatment of Tendinopathy

Exploring the Potential Mechanisms of Melilotus officinalis (L.) Pall. in Chronic Muscle Repair Patterns Using Single Cell Receptor-Ligand Marker Analysis and Molecular Dynamics Simulations

Using Network Pharmacology and Molecular Docking to Explore the Mechanism of Qiju Dihuang Pill against Dry Eye Disease

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