2010
DOI: 10.1016/j.jep.2010.08.048
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The flavonoid-rich fraction of Coreopsis tinctoria promotes glucose tolerance regain through pancreatic function recovery in streptozotocin-induced glucose-intolerant rats

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Cited by 89 publications
(79 citation statements)
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“…Since cinnamic acid derivatives have been reported to promote insulin secretion (Adisakwattana et al, 2008), the possibility that AFE affects insulin secretion is an interesting concept. There have been several studies on the hypoglycemic activity and antidiabetic effects of flowers and their constituents (Bhaskar et al, 2011;Dias et al, 2010;Nakamura et al, 2011); however, there have been no reports on these effects in a type 2 diabetes model. Although the influence of AFE on insulin secretion in normal mice was not elucidated in this study, plasma glucose levels were lowered in a dose-dependent manner with AFE in the ICR mice that had a normal insulin response.…”
Section: Kk-a Y Micementioning
confidence: 99%
“…Since cinnamic acid derivatives have been reported to promote insulin secretion (Adisakwattana et al, 2008), the possibility that AFE affects insulin secretion is an interesting concept. There have been several studies on the hypoglycemic activity and antidiabetic effects of flowers and their constituents (Bhaskar et al, 2011;Dias et al, 2010;Nakamura et al, 2011); however, there have been no reports on these effects in a type 2 diabetes model. Although the influence of AFE on insulin secretion in normal mice was not elucidated in this study, plasma glucose levels were lowered in a dose-dependent manner with AFE in the ICR mice that had a normal insulin response.…”
Section: Kk-a Y Micementioning
confidence: 99%
“…Our previous study indicated that the flavonoids extracted from CT show anti-hyperlipidemic effects, particularly in lowering triglycerides, reducing lipid deposition, and protecting liver function in an animal model [9]. Some pharmacological studies have also reported that CT is rich in flavonoids and can adjust glucose metabolism, promote blood circulation, and reduce cardiovascular disease risk [10,11]. Thus, a retrospective analysis was performed in patients with hyperlipidemia in this study, and we validated a protective role of CT in patients with hyperlipidemia.…”
Section: Introductionmentioning
confidence: 99%
“…have a significant amounts of bioactive components. 6,10,11 C. tinctoria is an annual forb widespread in Canada, Northeast Mexico, much of the United States, especially the Great Plains and Southern states, and is often called "calliopsis" by the native residents.…”
Section: Introductionmentioning
confidence: 99%