The Flinders Sensitive Line rat: A selectively bred putative animal model of depression

Overstreet, David H.; Friedman, Elliot; Mathé, Aleksander A.; Yadid, Gal

doi:10.1016/j.neubiorev.2005.03.015

Cited by 340 publications

(296 citation statements)

References 179 publications

(235 reference statements)

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“…In contrast to saccharin, sucrose has caloric value. It has been known that depression can be accompanied by both loss and the increase of appetite [21,27]; furthermore, antidepressant drugs, such as selective serotonin reuptake inhibitors, are commonly known to reduce appetite and curb weight gain [42][43][44]. Since the increase of taste preference in sucrose test 4 weeks after kindling can be excluded based on saccharin test, it is conceivable that increased sucrose intake reflects increased appetite.…”

Section: Discussionmentioning

confidence: 99%

“…Forced swim test (FST) is one of the most widely used protocols for studying both pharmacological and pathophysiological aspects of depression [21][22][23][24][25]. FST creates a situation of despair, and allows evaluation of the ability of the animal to adopt active strategies in inescapable stressful situation; failure to do so is indicative of a depression-like state [21,25] .…”

Section: Behavioral Testsmentioning

confidence: 99%

“…FST creates a situation of despair, and allows evaluation of the ability of the animal to adopt active strategies in inescapable stressful situation; failure to do so is indicative of a depression-like state [21,25] . We employed a modified FST, when the animals underwent a single five-minute trial [26]; such a modification of the classic Porsolt test [22] was shown to be relevant for both examining depressive state, and for screening antidepressant agents.…”

Section: Behavioral Testsmentioning

confidence: 99%

“…One of core symptoms of depression is the loss of the ability to experience pleasure, referred to as anhedonia [21,26,27]. In rats, anhedonia can be assessed by the loss of taste preference; while normal animals prefer sweetened water over regular water, animals with depression do not exhibit such a preference [23,24,[28][29][30].…”

Section: Behavioral Testsmentioning

confidence: 99%

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Kindling epileptogenesis in immature rats leads to persistent depressive behavior

Mazarati¹,

Shin²,

Auvin³

et al. 2007

Epilepsy & Behavior

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Depression is a frequent comorbidity in epilepsy patients. A variety of biological factors may underlie epilepsy-associated depression. We examined whether kindling-induced chronic increase in seizure susceptibility is accompanied by behavioral symptoms of depression. Three week-old Wistar rats underwent rapid kindling -84 initially subconvulsant electrical stimulations of ventral hippocampus delivered every five minutes -followed by depression-specific behavioral tests performed two and four weeks later. Kindled animals exhibited sustained increase in the immobility time in the forced swim test and the loss of taste preference towards calorie-free saccharin, as compared to controls. Initial loss of preference towards the intake of calorie-containing sucrose was followed by the increased consumption at four weeks. At both time points, animals exhibited enhanced seizure susceptibility upon test stimulations of the hippocampus. We conclude that neuronal plastic changes associated with kindling state are accompanied by the development of depressive behavior.

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Section: Discussionmentioning

confidence: 99%

Section: Behavioral Testsmentioning

confidence: 99%

Section: Behavioral Testsmentioning

confidence: 99%

Section: Behavioral Testsmentioning

confidence: 99%

See 2 more Smart Citations

Kindling epileptogenesis in immature rats leads to persistent depressive behavior

Mazarati¹,

Shin²,

Auvin³

et al. 2007

Epilepsy & Behavior

View full text Add to dashboard Cite

show abstract

“…They are less active in novel, openfield environments, and bar-presses at a lower rate for water or food reward (Overstreet and Russell, 1982). However, there was no evidence for anhedonia or cognitive disturbances (Overstreet et al, 2005) in FSL rats. Furthermore, FSL rats display severe immobility on the forced swim task (Kulkarni and Dhir, 2009;Overstreet et al, 1994) that is reversed with chronic treatment of antidepressants (Yadid et al, 2000).…”

Section: Introductionmentioning

confidence: 90%

Resting Glutamate Levels and Rapid Glutamate Transients in the Prefrontal Cortex of the Flinders Sensitive Line Rat: A Genetic Rodent Model of Depression

Hascup

Stephens

et al. 2011

Neuropsychopharmacol

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Despite the numerous drugs targeting biogenic amines for major depressive disorder (depression), the search for novel therapeutics continues because of their poor response rates (B30%) and slow onset of action (2-4 weeks). To better understand role of glutamate in depression, we used an enzyme-based microelectrode array (MEA) that was selective for glutamate measures with fast temporal (2 Hz) and high spatial (15 Â 333 mm) resolution. These MEAs were chronically implanted into the prefrontal cortex of 3-to 6-month-old and 12-to 15-month-old Flinders Sensitive Line (FSL) and control Flinders Resistant Line (FRL) rats, a validated genetic rodent model of depression. Although no changes in glutamate dynamics were observed between 3 and 6 months FRL and FSL rats, a significant increase in resting glutamate levels was observed in the 12-to 15-month-old FSL rats compared with the 3-to 6-month-old FSL and age-matched FRL rats on days 3-5 post-implantation. Our MEA also recorded, for the first time, a unique phenomenon in all the four rat groups of fluctuations in resting glutamate, which we have termed glutamate transients. Although these events lasted only for seconds, they did occur throughout the testing paradigm. The average concentration of these glutamate-burst events was significantly increased in the 12-to 15-month-old FSL rats compared with 3-to 6-month-old FSL and age-matched FRL rats. These studies lay the foundation for future studies of both tonic and phasic glutamate signaling in rat models of depression to better understand the potential role of glutamate signaling in depression.

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Animal Models and Procedures for CNS Disorders

Cutler

Sramek

Murphy

et al. 2010

Critical Pathways to Success in CNS Drug Development

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The Flinders Sensitive Line rat: A selectively bred putative animal model of depression

Cited by 340 publications

References 179 publications

Kindling epileptogenesis in immature rats leads to persistent depressive behavior

Kindling epileptogenesis in immature rats leads to persistent depressive behavior

Resting Glutamate Levels and Rapid Glutamate Transients in the Prefrontal Cortex of the Flinders Sensitive Line Rat: A Genetic Rodent Model of Depression

Animal Models and Procedures for CNS Disorders

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