The flower of Edgeworthia gardneri (wall.) Meisn. suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes

Gao, Die; Zhang, Yong-lan; Yang, Feng‐Qing; Li, Fan; Zhang, Qi‐Hui; Xia, Zhining

doi:10.1016/j.jep.2016.06.059

Cited by 23 publications

(21 citation statements)

References 35 publications

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“…At concentration of 1.0 mg/mL 90% reduction of these molecules was observed, considering that the extract has a potential to be used in development of functional foods (de Souza Marinho do Nascimento et al, 2017). Similar findings were reported by Gao et al (2016) who studied the activity of EEG rich extract (astragalin, daphnoretin and tiliroside were identified) from Edgeworthia gardneri (wall.) Meisn.…”

Section: In Vitro Studiessupporting

confidence: 87%

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Vasileva

Marchev

Georgiev

2018

Food and Chemical Toxicology

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Diverse groups of factors are leading to increased weight gain and obesity, such as certain genetic phenotypes, neuroendocrine disturbances, the administration of some drugs, behavioral, social and environmental factors. The progressively escalating rates of overweight and obesity worldwide have led to an introduction of a new term "globesity". Excessive accumulation of body fat and especially of visceral adipose tissue is the main predisposing factor for the development of metabolic syndrome and other obesity related co-morbidities. At the present moment only few pharmacotherapeuticals are used for long-term treatment of obesity acting on narrow target spectra, e.g. pancreatic and gastric lipase inhibition, acting as adrenomimetics or activating the satiety centers in hypothalamus. Plant-based medications that accelerate weight loss, proved to be safe, effective and widely available, would be a preferable alternative for anti-obesity treatments. As plant extracts are multi-component systems they could also act by more than one mechanism, including decreased lipid absorption, decreased energy intake, increased energy expenditure, decreased pre-adipocyte differentiation and proliferation, decreased lipogenesis and increased lipolysis. The current review gives a summary of the risk factors for obesity development and its characteristics consequences. Current treatment options, combining lifestyle changes and conventional treatment with commercial anti-obesity drugs have been described as well. Special emphasis on in vitro, in vivo and human studies, of potential medicinal plant extracts and phytochemicals, such as polyphenols, terpenoids, alkaloids, saponins, able to modulate the molecular pathways and gene/protein expressions related to obesity, have been highlighted.

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Section: In Vitro Studiessupporting

confidence: 87%

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Vasileva

Marchev

Georgiev

2018

Food and Chemical Toxicology

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“…In addition, pretreatment with an AMPK inhibitor weakened the inhibitory effects of the EEG extract on the expression of PPARγ and C/EBPα. These results demonstrated that the EEG extract exerted its antiadipogenic activity via the AMPK pathway (Gao et al., ).…”

Section: Biological Activities Of Tilirosidementioning

confidence: 80%

“…() 28.56 mg/g in Tilia americana ; and Gao et al. () 723.9 mg/g in Edgeworthia gardneri (Wall.) Meisn.…”

Section: Quantitative Analysismentioning

confidence: 98%

“…In this case, the use of HPLC‐PDA (or a diode array detector, DAD), a more rugged and well‐known instrument (instead of equipment that is more complex and expensive and that requires trained personnel) could help. In fact, generally, tiliroside can be easily detected at 330 nm as the detection wavelength for quantitative purposes (Gao et al., ).…”

Section: Quantitative Analysismentioning

confidence: 99%

“…The mechanism of this mode of action was partially explained by Gao et al. (), who analyzed the antiadipogenic effect of a tiliroside‐enriched ethyl acetate extract of the flowers of E. gardneri (EEG extract) in 3T3‐L1 adipocytes. EEG (in a concentration range of 12.5‐100 μg/mL) was proven to reduce lipid and triglyceride accumulations during the differentiation of adipocytes and to downregulate the adipogenesis‐related transcriptional factors PPARγ and C/EBPα.…”

Section: Biological Activities Of Tilirosidementioning

confidence: 99%

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A Review on the Dietary Flavonoid Tiliroside

Grochowski

Locatelli

Granica

et al. 2018

Comp Rev Food Sci Food Safe

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Among flavonoid derivatives, tiliroside is a flavonoid contained in several edible plants or specific plant parts (fruits, leaves, or roots). These parts are often widely used as both food and medicines, in the treatment of various ailments and, in some cases, as food supplements. Considering the easy access to many publications concerning tiliroside and the lack of a review that summarizes the current progress in studies on its safety, efficacy, and presence in the plant kingdom, we present here a review paper on tiliroside and its principal derivatives. The paper also highlights the basic knowledge regarding this molecule, its derivatives, and the analytical approaches used for extraction and quantification, as well as reports on the biological activities against different key enzymes linked to various human diseases. The reported information is also devoted to highlighting the concept "learn from nature to discover new products," particularly in the development of new drugs, food supplements, and nutraceuticals, starting from a natural lead compound such as tiliroside and improving its biological activities (and selectivities) against a specific target for therapeutic purposes.

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Molecularly imprinted polymers for the selective extraction of tiliroside from the flowers of Edgeworthia gardneri (wall.) Meisn

Gao

Wang

et al. 2017

J of Separation Science

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Nano-sized molecularly imprinted polymers for tiliroside were successfully prepared by a precipitation polymerization method. Acrylamide, ethylene glycol dimethacrylate, azobisisobutyronitrile, and acetonitrile/dimethyl sulfoxide were used as functional monomer, cross-linker, initiator, and porogen, respectively. The structural features and morphological characterization of tiliroside-imprinted polymers were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy, respectively. The adsorption experiments indicated that the tiliroside-imprinted polymers exhibited high selective recognition property to tiliroside. Scatchard analysis indicated that the homogeneous-binding sites were formed in the polymers. The selectivity test revealed that the adsorption capacity and selectivity of polymers to tiliroside was significantly higher than that of rutin, astragalin, and kaempferol. Finally, the tiliroside-imprinted polymers were employed as adsorbents in solid-phase extraction for the extraction of tiliroside from the ethyl acetate extract of the flowers of Edgeworthia gardneri (wall.) Meisn. The results demonstrated that the extraction recoveries of tiliroside ranged from 69.3 to 73.5% by using tiliroside-imprinted polymers coupled with solid-phase extraction method. These results indicated that the tiliroside-based molecularly imprinted solid-phase extraction method was proven to be an effective technique for the separation and enrichment of tiliroside from natural medicines.

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The flower of Edgeworthia gardneri (wall.) Meisn. suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes

Cited by 23 publications

References 35 publications

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

A Review on the Dietary Flavonoid Tiliroside

Molecularly imprinted polymers for the selective extraction of tiliroside from the flowers of Edgeworthia gardneri (wall.) Meisn

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