The Foot Experiment: Fragmentation Measurements in Particle Therapy

Alexandrov, A.; al., et

doi:10.21175/radj.2018.03.032

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…The silicon detectors, in the magnetic region, are able to perform momentum measurements with an expected resolution of about 5%, while the resolution supplied by the scintillator and by the calorimeter is about 3 and 2%, respectively, in the measurement of the energy loss and kinetic energy. The emulsion spectrometer is built using Emulsion Cloud Chamber (ECC) technology, alternating nuclear emulsion films with passive material [145]. A sketch of the ECC is shown in Figure 19.…”

Section: Description Of Programmentioning

confidence: 99%

Are Further Cross Section Measurements Necessary for Space Radiation Protection or Ion Therapy Applications? Helium Projectiles

et al. 2020

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The helium (4He) component of the primary particles in the galactic cosmic ray spectrum makes significant contributions to the total astronaut radiation exposure. 4He ions are also desirable for direct applications in ion therapy. They contribute smaller projectile fragmentation than carbon (12C) ions and smaller lateral beam spreading than protons. Space radiation protection and ion therapy applications need reliable nuclear reaction models and transport codes for energetic particles in matter. Neutrons and light ions (1H, 2H, 3H, 3He, and 4He) are the most important secondary particles produced in space radiation and ion therapy nuclear reactions; these particles penetrate deeply and make large contributions to dose equivalent. Since neutrons and light ions may scatter at large angles, double differential cross sections are required by transport codes that propagate radiation fields through radiation shielding and human tissue. This work will review the importance of 4He projectiles to space radiation and ion therapy, and outline the present status of neutron and light ion production cross section measurements and modeling, with recommendations for future needs.

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Section: Description Of Programmentioning

confidence: 99%

Are Further Cross Section Measurements Necessary for Space Radiation Protection or Ion Therapy Applications? Helium Projectiles

et al. 2020

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“…Therefore, an accurate knowledge of the target fragments production cross section is a fundamental requirement to correctly assess the biological dose of a proton beam. Waiting for FOOT experimental data [7], the different particle fluences of the mixed field has been studied for this purpose with FLUKA.…”

Section: Dose Averaged Let and Rbe Evaluationmentioning

confidence: 99%

“…The production cross sections of the target fragments are a topic of great interest but poor data are available: the direct measurement of target fragments is extremely difficult due to the short range of produced secondaries that have low probability to escape the target. The FOOT (FragmentatiOn Of Target) experiment [7][8][9][10] plans to use a complex experimental setup and an inverse kinematic approach to investigate the target fragments.…”

Section: Introductionmentioning

confidence: 99%

FLUKA simulation of target fragmentation in proton therapy

et al. 2020

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In proton therapy, secondary fragments are created in nuclear interactions of the beam with the target nuclei. The secondary fragments have low kinetic energies and high atomic numbers as compared to primary protons. Fragments have a high LET and deposit all their energy close to the generation point. For their characteristics, secondary fragments can alter the dose distribution and lead to an increase of RBE for the same delivered physical dose. Moreover, the radiobiological impact of target fragmentation is significant mostly in the region before the Bragg peak, where generally healthy tissues are present, and immediately after Bragg peak. Considering the high biological impact of those particles, especially in the case of healthy tissues or organs at risk, the inclusion of target fragmentation processes in the dose calculation of a treatment planning system can be relevant to improve the treatment accuracy and for this reason it is one of the major tasks of the MoVe IT project.In this study, Monte Carlo simulations were employed to fully characterize the mixed radiation field generated by target fragmentation in proton therapy. The dose averaged LET has been evaluated in case of a Spread Out Bragg Peak (SOBP). Starting from LET distribution, RBE has been evaluated with two different phenomenological models. In order to characterize the mixed radiation field, the production cross section has been evaluated by means of the FLUKA code. The future development of present work is to generate a MC database of fragments fluence to be included in TPS.

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The Foot Experiment: Fragmentation Measurements in Particle Therapy

Cited by 2 publications

References 18 publications

Are Further Cross Section Measurements Necessary for Space Radiation Protection or Ion Therapy Applications? Helium Projectiles

Are Further Cross Section Measurements Necessary for Space Radiation Protection or Ion Therapy Applications? Helium Projectiles

FLUKA simulation of target fragmentation in proton therapy

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