The foreign body reaction—an experimental protocol

Coleman, D. L.; King, Robert N.; Andrade, J. D.

doi:10.1002/jbm.820080308

Cited by 36 publications

(6 citation statements)

References 14 publications

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“…Brandao and colleagues have analyzed the biocompatibility of bioglass implants in the rabbit eviscerated socket. In line with previously published work [53]–[56], no systemic toxicity was observed and a pseudocapsule had formed after 90 days [57].…”

Section: Discussionsupporting

confidence: 92%

“…Bioglass was implanted in the maxillae and mandibles of baboons [53], subcutaneously in rats [54] and intramuscularly in rabbits [55]. An adverse inflammatory reaction at the implantation site was not observed in any of these experiments but a thin collagenous capsule can frequently be found at the interface between the bioglass implant and the surrounding tissue [56]. Brandao and colleagues have analyzed the biocompatibility of bioglass implants in the rabbit eviscerated socket.…”

Section: Discussionmentioning

confidence: 99%

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Safety Evaluation of a Bioglass–Polylactic Acid Composite Scaffold Seeded with Progenitor Cells in a Rat Skull Critical-Size Bone Defect

et al. 2014

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Treating large bone defects represents a major challenge in traumatic and orthopedic surgery. Bone tissue engineering provides a promising therapeutic option to improve the local bone healing response. In the present study tissue biocompatibility, systemic toxicity and tumorigenicity of a newly developed composite material consisting of polylactic acid (PLA) and 20% or 40% bioglass (BG20 and BG40), respectively, were analyzed. These materials were seeded with mesenchymal stem cells (MSC) and endothelial progenitor cells (EPC) and tested in a rat calvarial critical size defect model for 3 months and compared to a scaffold consisting only of PLA. Serum was analyzed for organ damage markers such as GOT and creatinine. Leukocyte count, temperature and free radical indicators were measured to determine the degree of systemic inflammation. Possible tumor occurrence was assessed macroscopically and histologically in slides of liver, kidney and spleen. Furthermore, the concentrations of serum malondialdehyde (MDA) and sodium oxide dismutase (SOD) were assessed as indicators of tumor progression. Qualitative tissue response towards the implants and new bone mass formation was histologically investigated. BG20 and BG40, with or without progenitor cells, did not cause organ damage, long-term systemic inflammatory reactions or tumor formation. BG20 and BG40 supported bone formation, which was further enhanced in the presence of EPCs and MSCs.This investigation reflects good biocompatibility of the biomaterials BG20 and BG40 and provides evidence that additionally seeding EPCs and MSCs onto the scaffold does not induce tumor formation.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Safety Evaluation of a Bioglass–Polylactic Acid Composite Scaffold Seeded with Progenitor Cells in a Rat Skull Critical-Size Bone Defect

et al. 2014

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“…The biocompatibility of the given material with tissue includes both local biological compatibility, i. e., the acute and chronic inflammatory responses and fibrous capsule formation, which is seen over various time periods following implantation of the respective material, and systemic compatibility, which implies no propagated effect to tissue remote from the site of implantation [91][92][93].…”

Section: Tissue-materials Compatibilitymentioning

confidence: 99%

Selected topics in biomedical polyurethanes. A review

Gogolewski

1989

Colloid & Polymer Sci

224

140

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“…Although they are recognized as non-self by nonspecific immunity (in contrast to the transplants), they are able to induce a serious inflammatory response (Refs. 1,2 The growth of keratinocytes (Kc) on the surface of synthetic hydrogels as cultivation supports was studied with respect to the influence of preincubation of these materials with bovine serum containing numerous bioactive proteins improving the adhesivity of cells (Ref. 5) in in vitro conditions.…”

Section: Synthetic Polymersmentioning

confidence: 99%

Interaction of cells with polymers

Smetana

Vacı́k

Dvořánková

1996

Macromolecular Symposia

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This paper summarizes the results of our experiments studying the effect of functional chemical groups of synthetic hydrophilic polymers on the recognition of these materials by macrophages in in vivo experiments. The interaction of keratinocytes with synthetic hydrophilic polymers in vitro is also demonstrated. The implants containing anionic groups (carboxylates) were shown to be better tolerated by nonspecific immunity. The keratinocytes are able to grow on hydrophilic polymer supports and migrate to surfaces with improved adhesivity (in vitro). The clinical applications of these experiments are demonstrated.

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The foreign body reaction—an experimental protocol

Cited by 36 publications

References 14 publications

Safety Evaluation of a Bioglass–Polylactic Acid Composite Scaffold Seeded with Progenitor Cells in a Rat Skull Critical-Size Bone Defect

Safety Evaluation of a Bioglass–Polylactic Acid Composite Scaffold Seeded with Progenitor Cells in a Rat Skull Critical-Size Bone Defect

Selected topics in biomedical polyurethanes. A review

Interaction of cells with polymers

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