1970
DOI: 10.1016/s0015-6264(70)80041-4
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The formation of aflatoxins B2a and G2a and their degradation products during the in vitro detoxification of aflatoxin by livers of certain avian and mammalian species

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Cited by 52 publications
(18 citation statements)
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“…Thus hydroxylation of AFB1 at C4 or C22 produces, AFM1 and AFQ1, respectively. Hydration of the C2 -C3 double bond results in the formation of AFB2a which is rapidly formed in certain avian species (Patterson and Roberts, 1970). AFP1 results from o-demethylation while the AFB1 -epoxide is formed by epoxidation at the 2,3 double bond.…”
Section: Metabolism and Mechanisms Of Action Of Aflatoxin B1mentioning
confidence: 99%
“…Thus hydroxylation of AFB1 at C4 or C22 produces, AFM1 and AFQ1, respectively. Hydration of the C2 -C3 double bond results in the formation of AFB2a which is rapidly formed in certain avian species (Patterson and Roberts, 1970). AFP1 results from o-demethylation while the AFB1 -epoxide is formed by epoxidation at the 2,3 double bond.…”
Section: Metabolism and Mechanisms Of Action Of Aflatoxin B1mentioning
confidence: 99%
“…Because all analyses were done in an identical manner, the lower recovery in PDPM may have resulted from the different protein contents of NDPM and PDPM. Aflatoxins have been reported to bind to protein (Gurtoo and Dahms, 1974;Peterson and Roberts, 1970), although the binding mechanism is not yet understood. Brackett and Marth (1982) used a non-specific protease, pronase, to digest milk naturally contaminated with aflatoxin M1 (AFM1) and suggested that AFMl bound to the milk protein, casein.…”
Section: Removal Of Aj?b By F Auruntiacummentioning
confidence: 99%
“…This has been associated to the high activity of the cytochrome P450 in mice than in the rats hence inducing the resistance to the carcinogenic effects of aflatoxin B1 in the mouse model [115]. The mechanism in rat models has been associated with the conversion of the aflatoxin B1 to aflatoxin M1 in vivo [117]. The same mechanism has been proved to work in vitro [118].…”
Section: Animal Models In the Assessment Of Mycotoxicosismentioning
confidence: 99%