The Four‐Component Reaction and Other Multicomponent Reactions of the Isocyanides

Organic Synthesis “On Water”

“…Multicomponent reactions provide rapid access to chemical diversity by combining several reactants into densely functionalized molecules. − Among the commonly used multicomponent reactions, Ugi and Passerini reactions are easily among the most versatile and widely utilized transformations. Pirrung and Sarma , examined these reactions in aqueous solutions and reported a significant increase in their rate and efficiency compared to organic solvents.…”