The Fourth Decade of Microfluidics

Kong, Tiantian; Shum, Ho Cheung; Weitz, David A.

doi:10.1002/smll.202000070

Cited by 38 publications

(19 citation statements)

References 14 publications

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“…Several other innovative combinations of microfluidics with new domains, such as artificial intelligence, metamaterials, and neuromorphic engineering, may bring about unprecedented technological advancements in the foreseeable future [152].…”

Section: Emerging and Future Applicationsmentioning

confidence: 99%

Fabrication and Applications of Microfluidic Devices: A Review

Niculescu

Chircov

Bîrcă

et al. 2021

IJMS

382

208

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Microfluidics is a relatively newly emerged field based on the combined principles of physics, chemistry, biology, fluid dynamics, microelectronics, and material science. Various materials can be processed into miniaturized chips containing channels and chambers in the microscale range. A diverse repertoire of methods can be chosen to manufacture such platforms of desired size, shape, and geometry. Whether they are used alone or in combination with other devices, microfluidic chips can be employed in nanoparticle preparation, drug encapsulation, delivery, and targeting, cell analysis, diagnosis, and cell culture. This paper presents microfluidic technology in terms of the available platform materials and fabrication techniques, also focusing on the biomedical applications of these remarkable devices.

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Section: Emerging and Future Applicationsmentioning

confidence: 99%

Fabrication and Applications of Microfluidic Devices: A Review

Niculescu

Chircov

Bîrcă

et al. 2021

IJMS

382

208

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“…Microbubbles of various sizes could be obtained because of the accurate manipulation of fluids through microfluidics. [31,32] By increasing the flow velocity of the aqueous phase (5-40 µL min −1 ) and maintaining the flow velocity of the gas phase (10 µL min −1 ), the diameter of the gas core decreased accordingly (Figure 2a; Figure S1b, Supporting Information). However, because of the high liquid viscosity and narrow orifice, the process of microbubble formation became unstable when the flow rate of the aqueous phase reached 50 µL min −1 .…”

Section: Resultsmentioning

confidence: 99%

Ultrasound‐Responsive Microfluidic Microbubbles for Combination Tumor Treatment

Huang

Zhang

Zhao

et al. 2021

Advanced Therapeutics

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Anticancer treatment is a worldwide challenge, and there are constant endeavors in this field to develop intelligent drug delivery systems to improve the therapeutic effect. This paper presents novel ultrasound-responsive delivery microbubbles (UDMs), with chemotherapeutic-encapsulated hydrogel shells and therapeutic gas cores. These are developed using microfluidic electrospray to treat pancreatic tumors. As the hydrogel shells are composed of thermo-sensitive poly(N-isopropylacrylamide) (PNIPAM), they can contract under mild hyperthermia generated by the acoustic-wave-induced oscillation of the encapsulated gas. Thus, by triggering with ultrasound, the chemotherapeutic Gemcitabine (Gem) encapsulated in the hydrogel shells and the hydrogen sulfide (H 2 S) encased in the cores can be controllably released. Based on the UDMs, it is demonstrated that the multiple drug-loaded microcarriers exhibit an excellent tumor-killing effect through combination therapy. The Gem and H 2 S coloaded UDMs have good therapeutic efficacy and adaptability in an orthotopic pancreatic implantation tumor model established in mice. These results indicate that the proposed UDMs have a large potential for codelivery of multiple drugs for treating deep-seated tumors and for realizing combination drug treatment to avoid untoward reactions.

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“…In this paper, we present a microfluidic 3D printing biomimetic polyhydroxyalkanoates-based scaffold with the desired features for loading multiple cells, and can effectively promote wound healing, as schemed in figure 1. Microfluidic technology has emerged as an effective tool to generate uniform and continuous fibers with controllability and micron characteristics [19,20]. In particular, the integration of 3D printing and microfluidic technologies provides a more effective choice for fabricating customized and highly ordered 3D-structured fibrous textiles [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Microfluidic 3D printing polyhydroxyalkanoates-based bionic skin for wound healing

et al. 2022

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Biomimetic scaffolds with extracellular matrix (ECM)-mimicking structure have been widely investigated in wound healing applications, while insufficient mechanical strength and limited biological activity remain major challenges. Here, we present a microfluidic 3D printing biomimetic polyhydroxyalkanoates-based scaffold with excellent mechanical properties and hierarchical porous structures for enhanced wound healing. This scaffold is composed of poly(3-hydroxybutyrate-4-hydroxybutyrate) (P34HB) and polycaprolactone (PCL), endowing it with excellent tensile strength (2.99 MPa) and degradability (80% of weight loss within 7 days). The ECM-mimicking hierarchical porous structure allows bone marrow mesenchymal stem cells (BMSCs) and human umbilical vein endothelial cells (HUVECs) to proliferate and adhere on the scaffolds. Besides, anisotropic composite scaffolds loaded with BMSCs and HUVECs can significantly promote re-epithelization, collagen deposition and capillary formation in rat wound defects, indicating their satisfactory in vivo tissue regenerative activity. These results indicate the feasibility of polyhydroxyalkanoates-based biomimetic scaffolds for skin repair and regeneration, which also provide a promising therapeutic strategy in diverse tissue engineering applications.

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The Fourth Decade of Microfluidics

Cited by 38 publications

References 14 publications

Fabrication and Applications of Microfluidic Devices: A Review

Fabrication and Applications of Microfluidic Devices: A Review

Ultrasound‐Responsive Microfluidic Microbubbles for Combination Tumor Treatment

Microfluidic 3D printing polyhydroxyalkanoates-based bionic skin for wound healing

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