The Frequency and Extent of Mammillary Body Atrophy Associated with Surgical Removal of a Colloid Cyst

Denby, Christine; Vann, Seralynne Denise; Tsivilis, Dimitris; Aggleton, John Patrick; Montaldi, Daniela; Roberts, Neil; Mayes, Andrew R.

doi:10.3174/ajnr.a1424

Cited by 31 publications

(19 citation statements)

References 39 publications

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“…A total of 38 colloid cyst patients received a standardized, structural MRI protocol (13,21,22). Of these, 26 patients completed all cognitive tests, including R/K and ROC.…”

Section: Resultsmentioning

confidence: 99%

“…A list of the 19 regions for which volumes were assessed is given in Table S1. Anatomical and MRI delineations for most of these regions have been published elsewhere (21,22).…”

Section: Methodsmentioning

confidence: 99%

“…All participants had a colloid cyst surgically removed from within the third ventricle at least 1 year before the investigation. A variety of surgical approaches (transfrontal, transcallosal, and endoscopic aspiration and excision) had been used to remove the cyst (21,22). Patients were excluded if they had additional neurological disorders or were under 18 years of age.…”

Section: Methodsmentioning

confidence: 99%

“…The patients and 20 age-matched normal controls were scanned at the same center with the same protocols (21,22). A list of the 19 regions for which volumes were assessed is given in Table S1.…”

Section: Methodsmentioning

confidence: 99%

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Impaired recollection but spared familiarity in patients with extended hippocampal system damage revealed by 3 convergent methods

Vann

Tsivilis²,

Denby³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

172

151

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To understand recognition memory, the detection of stimulus repetition, it first is necessary to resolve the debate between 2 fundamentally different models of recognition. Contemporary single-process models assume that recognition memory relies solely on the neural system required for the recall of prior events. Dual-process models assume that recognition comprises 2 independent forms of memory: one supports recall, and the other detects repeated stimuli by signaling their familiarity, the feeling of previous occurrence without the recall of any associated information. These 2 models were contrasted in patients who had undergone surgical removal of a colloid cyst, a condition associated with memory loss when accompanied by fornix and/or mammillary body atrophy. Comparisons were made between 2 groups of 9 patients that differed only with respect to the extent of mammillary body atrophy. Only the more atrophied group was impaired on tests of recall, but both groups showed normal recognition levels on a task that equates recall and recognition performance in normal participants. To explore the nature of this spared recognition, we estimated recall-based recognition and familiarity-based recognition using 3 distinct methods: self-report, receiver operating characteristics, and structural equation modeling. All 3 methods showed impaired recall-based recognition accompanied by intact familiarity in the most atrophied group, as predicted only by dual-process models. When structural equation modeling was applied to all 62 colloid cyst patients, the recall/familiarity dualprocess model best explained the patients' memory pattern. The convergent evidence that mammillary body atrophy impairs recall but spares familiarity-based recognition appears irreconcilable with single-process models.amnesia ͉ colloid cyst ͉ fornix ͉ mammillary body ͉ recognition

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“…A total of 38 colloid cyst patients received a standardized, structural MRI protocol (13,21,22). Of these, 26 patients completed all cognitive tests, including R/K and ROC.…”

Section: Resultsmentioning

confidence: 99%

“…A list of the 19 regions for which volumes were assessed is given in Table S1. Anatomical and MRI delineations for most of these regions have been published elsewhere (21,22).…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Impaired recollection but spared familiarity in patients with extended hippocampal system damage revealed by 3 convergent methods

Vann

Tsivilis²,

Denby³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

172

151

View full text Add to dashboard Cite

show abstract

“…Volume estimation was performed with the EasyMeasure program (www.liv. ac.uk/mariarc) (4,12). This software summated automatically the area of each slice and the TBV was calculated using the Cavalieri principle (12).…”

Section: Volumetric Analysismentioning

confidence: 99%

Macrocerebellum: a case report

Izbudak¹,

Acer²,

Poretti³

et al. 2014

Turkish Neurosurgery

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Macrocerebellum is a rare entity characterized by an enlarged cerebellum. We describe a case of a 48-month-old child with macrocerebellum. We performed serial volumetric analysis [total brain volume (TBV) and cerebellar volume] over a period of 4 years. We analyzed the white matter microstructure in the cerebellum using diffusion tensor imaging (DTI). In our patient, we found higher fractional anisotropy (FA) and lower mean diffusivity (MD) in the cerebellar white matter compared to age-matched controls. Our results may represent accelerated myelination secondary to the abnormal cerebellar development. KeywOrds: Macrocerebellum, Cerebellar volume, Total brain volume, Volume ratio, Diffusion tensor imaging ÖZNadir görülen bir hastalık olan makroserebellum, isminden de kolayca anlaşılacağı gibi serebellumun anormal bir şekilde büyük olması anlamına gelir. Bu çalışmada 48 aylık bir makroserebellum olgusu sunulmaktadır. Toplam beyin hacmi ve serebellum hacmi 4 yıllık bir periyotta 3 boyutlu manyetik rezonans görüntüleme (MRG) ile ölçülerek zaman içerisinde değişimi incelenmiştir. Hastanın MR görüntüleri üzerinde aynı zamanda atlas temelli diffüzyon tensör görüntüleme (DTG) analizi yapılmış, beyinciğin beyaz cevherinde fraksiyonel anizotropi (FA) ile ortalama diffüzivite (OD) değerleri hesaplanmış ve kontrollerle karsılaştırıldığında kontrol grubuna göre FA değerinin daha yüksek, OD değerinin daha düşük olması nedeni ile bu durumun serebellum gelişiminin anormalliğinden dolayı hızlı miyelinizasyona işaret edebileceği düşünülmüştür.

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Stereological Estimation of Brain Volume and Surface Area from MR Images

Acer

Turğut

2013

Neurostereology

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The Frequency and Extent of Mammillary Body Atrophy Associated with Surgical Removal of a Colloid Cyst

Cited by 31 publications

References 39 publications

Impaired recollection but spared familiarity in patients with extended hippocampal system damage revealed by 3 convergent methods

Impaired recollection but spared familiarity in patients with extended hippocampal system damage revealed by 3 convergent methods

Macrocerebellum: a case report

Stereological Estimation of Brain Volume and Surface Area from MR Images

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