The frequency and outcome of lupus nephritis: results from an international inception cohort study

Abstract

LN occurred in 38.3% of SLE patients, frequently as the initial presentation, in a large multi-ethnic inception cohort. Despite current standard of care, nephritis was associated with ESRD and death, and renal insufficiency was linked to lower health-related quality of life. Further advances are required for the optimal treatment of LN.

Renal histology in Indigenous Australians with lupus nephritis

“…22 Despite the lower burden of inflammation at biopsy, the outcomes for IA patients were poor compared to the NI patients and also lower than the reported 5-year survival in Texan Hispanics and African Americans. 5 The reasons for this increased risk of death and progression to ESRD are likely multifactorial; the majority of our IA cohort belonged to disadvantaged communities, where low socio-economic status, poor compliance and a high prevalence of comorbidity such as arterial hypertension and diabetes mellitus impact on the prognosis. 18,23 The observed survival disparity is not unique to LN as it is also seen in IA patients with cancer or receiving renal replacement therapy.…”

“…[1][2][3] Lupus nephritis (LN) is a major complication that usually develops early in the disease course and is more frequent and severe in non-Caucasian patients, where it carries a 5-20% risk of progression to end-stage renal disease (ESRD). 4,5 Earlier studies described a high frequency of clinical manifestations of LN in IA patients, 2,3 but there are no data on the underlying renal histopathology in IA. 6 This study investigated the incidence, histological characteristics and clinical outcome of LN in the largest hospital of the Northern Territory (NT), Australia, where approximately 27% of the population identifies as IA.…”

Update on Lupus Nephritis

“…SLE is more prevalent in women than men across all age groups and populations; the female-to-male ratio is highest at reproductive age, ranging between 8:1 and 15:1, and is lowest in prepubertal children at about 4:3 (1-3). The prevalence of SLE and the chances of developing lupus nephritis (LN) vary considerably between different regions of the world and different races and ethnicities (Table 1) (2,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). In the United States, the higher frequency of LN in black populations persists after adjustment for socioeconomic factors (15).…”

The Registry of Systemic Lupus Erythematosus Patients, a Eurasian Cohort (Renaissance)

“…В дебюте заболевания в 38,3% случаев выявлен ВН, который, несмотря на стан-дартное лечение, ассоциировался с развитием ХПН и вы-сокой смертностью. Предикторами неблагоприятного про-гноза являлись возраст дебюта заболевания после 40 лет, на-личие НП жизненно важных органов, а также использова-ние высоких доз ГК [1,2,30,41,42].…”