The Frequency and Prognostic Impact of Fever Following Transcatheter Aortic Valve Implantation

Abstract

Objectives: This study soughtto explore the frequency and prognostic implications of infectious and noninfectious fever following transcatheter aortic valve implantation (TAVI). Methods: We performed a retrospective cohort study including 194 consecutive patients who underwent TAVI at our institution. We identified and characterized all patients who developed fever within the first 72 h following the procedure. We determined the etiology of the fevers (infectious vs. noninfectious) and assessed their impact on in-hospital complications and 1-year mortality. Results: Following TAVI,65 (33.5%) patients had fever (mean age 83.7 ± 3.8 years, 70.2% female). An infectious etiology was evident in only 17 of the 65 patients (26.1%) with fever, mainly due to pneumonia (52.9%) and a urinary tract infection (41.2%). No significant difference was observed in baseline characteristics, the mean fever temperature/duration, or signs of inflammatory response between infectious and noninfectious fevers. The mean hospital duration was longer (7 ± 4.8 days vs. 4.7 ± 2.4 days, p = 0.01) among patients with an infectious fever; however, fever had no impact on the 1-year mortality rate (5.9 and 4.5%, respectively, p = 0.71). Conclusions: Our study demonstrates that, although fever was a common phenomenon after TAVI, it represented an infectious complication only in a minority of cases. Nevertheless, fever, infectious or not, had no impact on the 1-year mortality rate following TAVI.

Temporary Trends in Fever following Transcatheter Aortic Valve Implantation

“…Other factors were female gender, vascular complications, transfemoral access, and reduced GFR. In line with prior findings [1], fever following TAVI was not associated with increased mortality but with a longer hospital stay.…”

“…The occurrence of fever following transcatheter aortic valve implantation (TAVI) is a well-known phenomenon during the first 72 h after TAVI, which may occur from systemic inflammatory response syndrome (SIRS) rather than an infectious cause [1][2][3][4][5][6][7][8][9]. SIRS in TAVI patients is presumably multifactorial, associated DOI: 10.1159/000511621 with implanted devices, biomaterial, and procedural aspects [10].…”

Type of Atrial Fibrillation and Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement

“…[21][22][23] In brief, all patients with severe and symptomatic aortic stenosis were referred to a dedicated consultation "heart team" forum at our hospital. The design and management of the Rabin Medical Center TAVR registry has been reported previously.…”

“…The design and management of the Rabin Medical Center TAVR registry has been reported previously. [21][22][23] In brief, all patients with severe and symptomatic aortic stenosis were referred to a dedicated consultation "heart team" forum at our hospital. All patients considered for valve replacement were assessed by coronary and peripheral angiography.…”

Systemic Inflammatory Response following Transcatheter Aortic Valve Implantation

“…In a recent issue of Cardiology , Orvin et al [1] report on their experience with 198 consecutive patients who underwent transcatheter aortic valve implantation (TAVI) at the Rabin Medical Center in Petach Tikva, Israel. This was a retrospective cohort study of all patients with severe symptomatic aortic stenosis who were deemed inoperable or at high surgical risk for conventional aortic valve replacement.…”